Patents Examined by Yong Chu
  • Methods for isolating crystalline form I of 5-azacytidine
    Patent number: 8975392
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 10, 2015
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Lee Alani Selvey
  • Peritoneal dialysis solutions comprising glucose polymers
    Patent number: 8975240
    Abstract: Peritoneal dialysis solutions including a glucose polymer and methods of using the dialysis solutions are disclosed herein. In a general embodiment, the peritoneal dialysis solution includes a glucose polymer in an amount to provide an increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed compared to conventional dialysis solutions containing icodextrin as the active pharmaceutical ingredient. The increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed is obtained by providing specific combinations of weight-average molecular weight, polydispersity index and concentration of the glucose polymer in the dialysis solution.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: March 10, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: John Kenneth Leypoldt, Clifford J. Holmes, Sujatha Karoor, Catherine M. Hoff, Leo Martis, Rahul Tandon
  • Oxadiazole derivative, and light-emitting element, light-emitting device, electronic device, and lighting device using the oxadiazole derivative
    Patent number: 8969579
    Abstract: An object of one embodiment of the present invention is to provide a novel oxadiazole derivative as a substance having high excitation energy, in particular, a substance having high triplet excitation energy. One embodiment of the present invention is an oxadiazole derivative represented by General Formula (G1) below. In General Formula (G1), R1 represents either an alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted aryl group having 6 to 13 carbon atoms. In General Formula (G1), R21 to R27 separately represent any one of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, and a substituted or unsubstituted aryl group having 6 to 13 carbon atoms. In General Formula (G1), ? represents a substituted or unsubstituted arylene group having 6 to 13 carbon atoms. In General Formula (G1), Z represents either a sulfur atom or an oxygen atom.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: March 3, 2015
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Yuko Kawata, Hiroshi Kadoma, Nobuharu Ohsawa, Satoshi Seo
  • Lactic acid direct synthesis process
    Patent number: 8962882
    Abstract: This invention concerns a process for obtaining lactic acid in a single stage by direct oxidation in an aqueous medium of 1,2-propanediol in the presence of a mixture of heterogeneous catalysts, in conditions of low temperature and low pressure. The reaction takes place in the presence of oxygen and a mixture of heterogeneous catalysts, consisting of a first catalyst of noble metal supported in metallic oxide, and a second basic solid catalyst. The mixture of catalysts is easily recovered by filtration at the end of the process, to be reused. The lactic acid is obtained directly, with selectivity between 50% and 97%.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: February 24, 2015
    Assignees: Petroleo Brasileiro S.A.—Petrobras, Int—Instituto Nacional de Tecnologia
    Inventors: Marco André Fraga, Tatiana Vieira Galvão, Simone Maria De Rezende, Andrea Maria Duarte De Farias, Alexandre Barros Gaspar, Marlito Gomes Junior, Carlos René Klotz Rabello, Bernardo Galvão Siqueira, Raphael Bezerra De Menezes
  • Small molecule inhibitors of the pleckstrin homology domain and methods for using same
    Patent number: 8962663
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: February 24, 2015
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
  • Photoelectric conversion devices comprising novel ligands and sensitizers
    Patent number: 8962977
    Abstract: The present invention provides novel dyes for dye sensitized photovoltaic conversion devices. The dyes contain novel anchoring ligands, which have a vinyl or phenylethenyl moiety incorporated in the anchoring bipyridine. Such dyes exhibit an increased molar extinction coefficient and enhanced red response in the visible regions.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: February 24, 2015
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Mohammad Nazeeruddin, Michael Graetzel
  • Process for preparing methyl formate by reaction of methanol with carbon monoxide in the presence of a catalyst system comprising alkali metal formate and alkali metal alkoxide
    Patent number: 8957244
    Abstract: Process for preparing methyl formate by carbonylation of methanol by means of carbon monoxide in a carbonylation reactor in the presence of a catalyst system comprising alkali metal formate and alkali metal alkoxide to give a reaction mixture (RM) which comprises methyl formate, alkali metal formate, alkali metal alkoxide and possibly unreacted methanol and unreacted carbon monoxide and is taken from the carbonylation reactor, wherein the reaction mixture (RM) comprises at least 0.5% by weight of alkali metal alkoxide based on the total weight of the reaction mixture (RM) and the molar ratio of alkali metal formate to alkali metal alkoxide in the reaction mixture (RM) is greater than 1.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: February 17, 2015
    Assignee: BASF SE
    Inventors: Daniel Schneider, Klaus-Dieter Mohl, Martin Schäfer, Jürgen Paschold, Joaquim Henrique Teles, Stefan Rittinger
  • Thiophene derivatives
    Patent number: 8952178
    Abstract: Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the present application.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: February 10, 2015
    Assignees: Tianjin Hemay Bio-Tech Co., Ltd., Tianjin Michele Sci-Tech Development Co., Ltd.
    Inventors: Hesheng Zhang, Guanghuai Zeng, Yifei Gao
  • N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
    Patent number: 8951536
    Abstract: The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions thereof and methods of use thereof relating to the treatment of cancer and other diseases.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 10, 2015
    Assignee: Incyte Corporation
    Inventors: Andrew P. Combs, Amy Takvorian, Wenyu Zhu, Richard B. Sparks
  • Cyclopentylacrylamide derivative
    Patent number: 8946440
    Abstract: A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of diabetes, obesity, and the like. The compound is represented by the general formula (1): (wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1 to C6 alkyl group, a C1 to C6 alkoxy group, a C1 to C6 alkylsulfanyl group, a C1 to C6 alkylsulfinyl group, a C1 to C6 alkylsulfonyl group, or a C1 to C6 alkoxy-C1 to C6 alkylsulfonyl group, and A is a substituted or unsubstituted heteroaryl group).
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: February 3, 2015
    Assignees: Kyorin Pharmaceutical Co., Ltd., Teijin Pharma Limited
    Inventors: Yasumichi Fukuda, Yoshikazu Asahina, Masanori Takadoi, Masanori Yamamoto
  • Process for producing fatty alcohols by hydrogenation of fatty acid triglycerides on a copper-containing heterogeneous catalyst
    Patent number: 8946490
    Abstract: The present invention relates to a process for preparing fatty alcohols, in which a stream comprising at least one fatty acid triglyceride is provided and this stream is subjected to a hydrogenation in the presence of a heterogeneous copper catalyst.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: February 3, 2015
    Assignee: BASF SE
    Inventors: Daniela Mirk, Roman Prochazka, Jochem Henkelmann, Markus Hölzle, Daniela Herzberg
  • Methods and compositions for treatment of autism
    Patent number: 8937050
    Abstract: Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: January 20, 2015
    Assignees: The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Paul Talalay, Andrew W. Zimmerman, Kirby D. Smith
  • 3-(phenoxyphenylmethyl)pyrrolidine compounds
    Patent number: 8933249
    Abstract: In one aspect, the invention relates to compounds of formula I: where a and R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: January 13, 2015
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Eric L. Stangeland, Priscilla Van Dyke, Timothy J. Church, Lori Jean Patterson, Daisuke Roland Saito
  • Photo-responsive liquid crystalline compound and its applications
    Patent number: 8933208
    Abstract: The purpose of the present invention is to provide novel liquid crystalline compounds that are capable of inducing phase transition by a light stimulus and are useful in the display, optoelectronics, and photonics field. The present invention relates to the liquid crystalline compounds represented by general formula (1): wherein R1, R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, alkoxyl, alkoxycarbonyl, alkoxycarbonyloxy, alkanoyl, alkanoyloxy, alkoxyphenyl, and N-alkylaminocarbonyl, and n is an integer.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: January 13, 2015
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Yasuo Norikane, Yuki Hirai, Masaru Yoshida
  • Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
    Patent number: 8932842
    Abstract: Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: January 13, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue, He Huang
  • Method for producing carbamate compound, carbamate compound, and method for producing isocyanate compound using same
    Patent number: 8927756
    Abstract: The present invention relates to a method of producing a carbamate compound, comprising reacting a fluorine-containing carbonic diester compound represented by formula (1) and a non-aromatic diamine compound represented by formula (2) without using a catalyst, to thereby produce a carbamate compound represented by formula (3), and a method of producing an isocyanate compound represented by formula (20) from the carbamate compound without using a catalyst, wherein R represents a fluorine-containing monovalent aliphatic hydrocarbon group, and A represents a divalent aliphatic hydrocarbon group, a divalent alicyclic hydrocarbon group or a divalent aromatic-aliphatic hydrocarbon group.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: January 6, 2015
    Assignee: Asahi Glass Company, Limited
    Inventors: Takashi Okazoe, Yuko Nagasaki, Hidekazu Okamoto
  • Hair care cosmetic
    Patent number: 8927751
    Abstract: Disclosed herein is a hair care cosmetic which contains an organopolysiloxane defined in following (i) or (ii): (i) an organopolysiloxane in which the organopolysiloxane segment constituting the backbone has the substituent group represented by the following formula (1) which is connected to at least one silicon atom in the segment; wherein Z is an organic group represented by the following formula (2); (ii) an organopolysiloxane in which the organopolysiloxane segment constituting the backbone has the substituent group represented by the following formula (1?) and the substituent group represented by the following formula (3) which are connected to separate silicon atoms in the segment; —X—NH—Z ??(1?) wherein Z is an organic group represented by the following formula (2).
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: January 6, 2015
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Hiroyuki Moriya
  • Process and apparatus for recovery of dichlorohydrins via codistillation
    Patent number: 8926916
    Abstract: A process and apparatus for recovering dichlorohydrins from a mixture comprising dichlorohydrins, one or more compounds selected from esters of dichlorohydrins, monochlorohydrins and/or esters thereof, and multihydroxylated-aliphatic hydrocarbon compounds and/or esters thereof, and optionally one or more substances comprising water, chlorinating agents, catalysts and/or esters of catalysts is disclosed. The mixture is stripped to recover dichlorohydrin(s) while distilling or fractionating the mixture to separate a lower boiling fraction comprising dichlorohydrin(s) from the mixture in one step. Advantages include more efficient recovery of dichlorohydrins for a given distillation column, less waste due to avoiding the conditions conducive to the formation of heavy byproducts, and reduced capital investment in recovery equipment.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 6, 2015
    Assignee: Dow Global Technologies LLC
    Inventors: Danil Tirtowidjojo, Andrei S. Merenov, Christian D. Kneupper, Bruce D. Hook, Anil Mehta
  • Compositions and methods for the treatment of metabolic disorders
    Patent number: 8927578
    Abstract: The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog thereof. In other aspects, the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures and are described in detail herein. In specific aspects, the metabolic disorder includes obesity or diabetes, for example.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: January 6, 2015
    Assignee: Baylor College of Medicine
    Inventors: Motonari Uesugi, Salih J. Wakil, Lutfi Abu-Elheiga, Qian Mao, Shinji Kamisuki, Akira Kugimiya
  • Fluorescent dyes
    Patent number: 8921543
    Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: December 30, 2014
    Assignee: AnaSpec Incorporated
    Inventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing