Abstract: Rinsable dyes with improved fugitivity are formulated by attaching dyestuff compounds with amine-capped sulfonic solubilizing groups to commercially available ethoxylated aniline, so that the surfactant effect of the ethoxylated aniline counteracts the substantivity of the dyestuff compound, while the neutralization of the sulfonic solubilizing groups reduces substantivity.
Type:
Grant
Filed:
May 16, 2012
Date of Patent:
August 12, 2014
Assignee:
Spectra Colors Corp.
Inventors:
Mark Berenfeld, Sai Harfouch, Peter Caputo
Abstract: This invention relates to the use of triazolone derivatives of Formula (I) for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of triazolones in the treatment of cancer.
Type:
Grant
Filed:
February 22, 2011
Date of Patent:
August 12, 2014
Assignee:
GlaxoSmithKline LLC
Inventors:
Nicholas D. Adams, Christopher Joseph Aquino, Amita M. Chaudhari, Jonathan M. Ghergurovich, Terence John Kiesow, Cynthia A. Parrish, Alexander Joseph Reif, Kenneth Wiggall
Abstract: The present invention relates to pyrazole oxadiazoles derivatives of Formula (I), and their use for treating multiple sclerosis and other diseases, wherein R1, R2 and R3 are as defined in the description.
Type:
Grant
Filed:
June 7, 2010
Date of Patent:
August 12, 2014
Assignee:
Merck Serono SA
Inventors:
Anna Quattropani, Charles Baker-Glenn, Wesley Blackaby, Chris Knight
Abstract: The invention relates to oxadiazole compounds of formula I. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
Type:
Grant
Filed:
March 29, 2010
Date of Patent:
August 12, 2014
Assignee:
Merck Serono SA
Inventors:
Anna Quattropani, Cyril Montagne, Wolfgang Sauer, Stefano Crosignani, Agnès Bombrun
Abstract: Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying acetic acid and an alcohol such as ethanol to produce an esterification product. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising the alcohol, in particular ethanol, which may be separated from the crude reaction mixture. Ethyl acetate from the crude reaction mixture may be recovered as returned to assist in recovering the esterification product.
Type:
Grant
Filed:
November 18, 2011
Date of Patent:
August 12, 2014
Assignee:
Celanese International Corporation
Inventors:
R. Jay Warner, Wei Qi, Tatiana Sonnenberg
Abstract: The invention relates to novel compounds which are naphthalene diimides of general formula (I). The compounds are used in therapy, particularly in cancer treatment.
Type:
Grant
Filed:
November 28, 2008
Date of Patent:
August 5, 2014
Assignee:
University College London
Inventors:
Mekala Gunaratnam, Francisco Cuenca, Stephen Neidle
Abstract: A process for preparing an N,N-dialkylethanolamine of the formula I having high color stability where R1 and R2 are each independently a C1- to C8-alkyl group, by reacting ethylene oxide (EO) with a corresponding dialkylamine (R1R2NH) in the presence of water, wherein the reaction is effected continuously in a reactor, the reaction temperature is in the range from 90 to 180° C. and the residence time (RT) in the reactor is in the range from 1 to 7 min, the reactor output is treated thermally at a temperature in the range from 80 to 160° C. over a period in the range from 20 to 1000 min, and then the N,N-dialkylethanolamine is removed by distillation.
Type:
Grant
Filed:
December 16, 2011
Date of Patent:
July 29, 2014
Assignee:
BASF SE
Inventors:
Frank-Friedrich Pape, Johann-Peter Melder, Alfred Krause, Roland Bou Chedid, Martin Rudloff
Abstract: The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L1, L2, X, L3, Y, R1 and R2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances.
Type:
Grant
Filed:
January 24, 2011
Date of Patent:
July 29, 2014
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Thorsten Oost, Ralf Anderskewitz, Dieter Wolfgang Hamprecht, Christoph Hoenke, Domnic Martyres, Wolfgang Rist, Peter Seither
Abstract: The present invention relates to a method for manufacturing a water resistant optically anisotropic film comprising: a water resistant treatment step of bringing an optically anisotropic film containing an organic dye having an anionic group into contact with a water resistant treatment liquid containing a multivalent metal salt or a compound having two or more nitrogen atoms in a molecule thereof; and a cleaning step of cleaning the optically anisotropic film after the water resistant treatment, using a cleaning liquid containing a hydrophilic organic compound.
Abstract: The present invention relates to a process for preparing aminopolycarboxylates proceeding from an amino acid which, in a first process step is reacted with ethylene oxide to give an intermediate mixture comprising the corresponding dialkanolamine, and then the intermediate mixture, in a second process step is converted catalytically using a base to the corresponding aminopolycarboxylate, wherein the amino acid, before the reaction with ethylene oxide in the first process step, is supplied to a partial neutralization with 0.70 to 0.99 equivalent of base per acid group, or, in the first process step, an amino acid which has already been partly neutralized with 0.70 to 0.99 equivalent of base per acid group is used.
Type:
Grant
Filed:
March 26, 2012
Date of Patent:
July 22, 2014
Assignee:
BASF SE
Inventors:
Robert Baumann, Markus Christian Biel, Axel Franzke, Thomas Heidenfelder, Paul Klingelhoefer, Alfred Oftring
Abstract: It is an object of the present invention to provide a mixed catalyst for a vapor-phase catalytic oxidation or a vapor-phase catalytic ammoxidation reaction of propane, or isobutene, capable of providing a corresponding unsaturated acid or unsaturated nitrile at high yield from propane or isobutene.
Abstract: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.
Type:
Grant
Filed:
October 14, 2011
Date of Patent:
July 22, 2014
Assignee:
XenoPort, Inc.
Inventors:
Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A. Virsik
Abstract: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.
Type:
Grant
Filed:
October 14, 2011
Date of Patent:
July 15, 2014
Assignee:
XenoPort, Inc.
Inventors:
Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A. Virsik
Abstract: The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
Type:
Grant
Filed:
May 8, 2009
Date of Patent:
July 15, 2014
Assignee:
Janssen Pharmaceutica NV
Inventors:
Johannes Wilhelmus John F. Thuring, Gregor James MacDonald, Wei Zhuang
Abstract: Processes for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprise: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound.
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type:
Grant
Filed:
September 7, 2012
Date of Patent:
July 15, 2014
Assignee:
Pharmacyclics, Inc.
Inventors:
Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young
Abstract: The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog thereof. In other aspects, the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures and are described in detail herein. In specific aspects, the metabolic disorder includes obesity or diabetes, for example.
Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatments of protein kinase mediated diseases, including inflammation and related conditions.
Type:
Grant
Filed:
October 7, 2009
Date of Patent:
July 8, 2014
Assignee:
Amgen Inc.
Inventors:
Andrew Tasker, Liping H. Pettus, Ryan Wurz
Abstract: Rinsable dyes with improved fugitivity are formulated by attaching dyestuff compounds with amine-capped sulfonic solubilizing groups to commercially available ethoxylated aniline, so that the surfactant effect of the ethoxylated aniline counteracts the substantivity of the dyestuff compound, while the neutralization of the sulfonic solubilizing groups reduces substantivity.
Type:
Grant
Filed:
July 26, 2012
Date of Patent:
July 8, 2014
Assignee:
Spectra Colors Corp.
Inventors:
Mark Berenfeld, Sal Harfouch, Peter Caputo
Abstract: The present invention provides a means which can inhibit release of I2 in production or storage of 1,3-diiodohydantoin compound, and thereby solve decrease in purity of the compound and various problems caused by I2. The present invention provides a production method for 1,3-diiodohydantoin compound comprising a step to prepare a wet body containing a 1,3-diiodohydantoin compound, and (1) a step to dry the wet body by contacting the wet body with heated gas or (2) a step to lyophilize the wet body, a storage method for 1,3-diiodohydantoin compound comprising a step to store a 1,3-diiodohydantoin compound under a temperature condition of 15° C. or lower, and a 1,3-diiodohydantoin compound wherein content of released I2 is 1% by mass or less.