Patent number: 7635494
Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.
Type:
Grant
Filed:
March 28, 2008
Date of Patent:
December 22, 2009
Assignee:
Piramal Life Sciences Limited
Inventors:
Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu