Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Abstract: A rotary knife includes a blade housing, an annular blade, and a grease cup assembly. The blade housing includes a housing race, a first inlet bore, a first lubricant channel, a second inlet bore, and a second lubricant channel. Each lubricant channel extends from the housing race to the respective inlet bore. The annular blade includes a blade race engaging the housing race so that the annular blade is rotatably supported by the blade housing. The grease cup assembly is coupled to the blade housing so as to selectively be in communication with one of the first and second inlet bores. The grease cup assembly is configured to inject a lubricant to the housing race through the lubricant channel.

Abstract: Designing a circuit to perform a floating point arithmetic operation by identifying a multiple of parameters that characterize circuits for performing the floating point arithmetic operation and an equation relating the plurality of parameters to a maximum relative backward error parameter, the circuits respectively corresponding to combinations of values for the parameters; specifying a target maximum relative backward error for the floating point arithmetic operation; computing a maximum relative backward error for each of one or more of the combinations of values based on the equation; and when the maximum relative backward error for a respective combination of values is less than the target maximum relative backward error, identifying the circuit corresponding to the maximum relative backward error as a circuit operable to perform the floating point arithmetic operation at a desirable output accuracy.

Abstract: Disclosed are polymer compositions comprising activated carbon and method of making the polymer compositions that are used for sorption of formaldehyde from air, gas or liquids. The activated carbon is entrained in at least one base polymer with optional channels throughout.

Abstract: Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.

Abstract: Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.

Abstract: Provided is a system and method for pseudo-identifier to license plate number link repair, the method including: generating a security luggage item manifest listing a checked-in luggage items terminating or transferring at a border crossing airport, each of checked-in luggage items including a scannable bag tag, and the security luggage item manifest including a first unique baggage identifier for the scannable bag tags; determining whether a secure database is missing a link between the first unique baggage identifier for a respective checked-in luggage item and a second unique baggage identifier assigned by a baggage handling system to retrieve a security screening image (SSI) of the checked-in luggage item; based on determining that the link is missing, extrapolating the first unique baggage identifier for the luggage item based on the second unique baggage identifier; retrieving the SSI linked to the extrapolated first unique baggage identifier of the respective checked-in luggage item; converting the ext

Abstract: Nitrification inhibitors and uses of same to prevent nitrate leaching or nitrous oxide emissions as well as increase pasture or crop production. The nitrification inhibitors and formulations including same may be used for direct or indirect application to soil or pasture.

Abstract: A system for automatically handling components to be assembled onto a product on an assembly line includes a carriage that is movable to and between a first, retracted position spaced from the assembly line, and a second position displaced from the retracted position in a direction toward the assembly line. A manipulator on the carriage supports a component mounting tool configured to receive and support at least one component for assembly to the product. The manipulator may be arranged in a first orientation when the carriage is in the first position, and may be pivoted to a second orientation when the carriage is in the second position, such that a component on the component mounting tool is supported in a pose for processing when the carriage is in the first position, and is supported in a pose for joining to the product when the carriage is in the second position.

Abstract: A method of operating a forced induction gaseous-fueled engine includes mixing gaseous-fuel and engine intake air to form a mixture at a fuel mixer. The method includes delivering the mixture to an intake manifold by at least partially bypassing a charge air cooler.

Abstract: An example of an apparatus is provided. The apparatus includes a bag to store an item. The bag includes an opening to receive the item. The apparatus further includes first and second straps connected to opposite ends of the bag. The apparatus additionally includes a first adhesive surface disposed on the first strap. The first adhesive surface is to connect to the first strap to secure the first strap to a first location of a handle of a pushcart. The apparatus also includes a second adhesive surface disposed on the second strap. The second adhesive surface is to connect to the second strap to secure the second strap to a second location of the handle. The first strap and the second strap are to suspend the bag below the handle of the pushcart to provide access to the opening to move the item into and out of the bag.

Abstract: The present disclosure provides compounds that are useful for the treatment of conditions mediated by MRGPRX2. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment using such compounds.

Abstract: A flexible lift assist harness is configured to allow caregivers to assist patients with limited mobility. The flexible lift assist harness may include a flexible belt assembly which may be secured to the torso of the patient, and in some cases at least one leg anchor assembly which may be secured to a leg of the patient.

Abstract: A method of forming a diamond coated glass structure includes providing a glass substrate having a first and a second side. The second side can be covered in whole or in part with a coating capable of reducing ion exchange. The substrate can be bent to form the first side as convex and the second side as concave. A CVD diamond layer can be deposited on the convex first side of the substrate and at least a portion of the substrate chemically modified through ion exchange. After removal of the stress, the stresses due to applied diamond layers and chemical modification through ion exchange can balance, providing a substantially flat diamond coated glass structure.

Abstract: Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.

Abstract: A method and system that utilizes an admissible heuristic to determine the fastest-path between two points on a road map is disclosed. The method and system are based in part on a set of separators disposed on the map and represented by line segments, either independent or organized into hierarchical tree structures and based on recursive spatial subdivision. A preprocessing step computes a vector of values per road junction based on the separators that is then stored with the map and used to efficiently compute a high-quality heuristic to be used at a query stage. The heuristic scales well to any map size, resulting in a very efficient determination of fastest-path queries between points at all distances. The implementation is economically feasible and the resulting query speeds are significantly faster than other known heuristics and other state-of-the-art systems used for computing fastest-paths on maps.

Abstract: According to some embodiments, a longitudinal door system comprising one or more longitudinal doors for a railcar and a longitudinal operating beam coupled to the one or more longitudinal doors via one or more struts. A translation of the longitudinal operating beam is coupled to an opening and closing of the one or more longitudinal doors. The door system further comprising a gearbox coupled to the longitudinal operating beam and a first capstan receptacle. The gearbox is operable to translate a rotational movement of the first capstan receptacle to a linear movement of the longitudinal operating beam.

Abstract: A transformer apparatus for an electrical power transformation system is provided. The transformer apparatus comprises three outer transformer limbs, an inner transformer limb a transfer star, and first and second connection portions. The transfer star comprises an electromagnetic transfer core and three transfer coils. The electromagnetic transfer core extends from the inner transformer limb to each of the three outer transformer limbs at a point on each outer transformer limb between the first coil assembly and the second coil assembly. The transfer coils are wound around the electromagnetic transfer core such that each transfer coil is arranged between the inner transformer limb and a respective outer transformer limb. The transfer star is configured to allow transfer of magnetomotive force between the outer transformer limbs and the inner transformer limb of the transformer apparatus. First and second connecting portions are to allow magnetic flux to flow between the inner and outer transformer limbs.

Abstract: A computer-implemented method of providing one or more content item recommendations for a user of a content distribution system, comprising: determining if a user search using a title of content finds the title of content in one or more content sources available to the user; identifying, in response to the title of content not being found in the one or more content sources, content in a content library by determining if the title of content is in the content library, wherein the content library contains metadata concerning items of content in the content library, the metadata representing at least some properties of the items of content; using, in response to the title of content being determined to be in the content library, the metadata of the identified content in the content library and metadata concerning content available from the one or more content sources available to the user to generate at least one content item recommendation for the user, wherein the at least one content item recommendation is fo

Abstract: A method and system for servicing requests, including receiving, from a client, a first request to perform an action, obtaining a first persona object for a user associated with the first request, servicing the first request using the first persona object to obtain a result, and providing the result to the client.