Patents by Inventor A. P. Lin
A. P. Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150079260Abstract: A grilling belt includes a flexible support having first and second major surfaces, an extruded fluoropolymer layer overlying the first major surface, and a cast or skived fluoropolymer layer overlying the extruded fluoropolymer layer. Another grilling belt can include a support having first and second major surfaces, and a first fluoropolymer film overlying the first major surface. The support can include a first fabric having a first bias angle, and a second fabric laminated to the first fabric and having a second bias angle different from the first bias angle by between 20° and 160°.Type: ApplicationFiled: November 17, 2014Publication date: March 19, 2015Inventors: Hua Fan, Anne B. Hardy, Timothy P. Pollock, Ephraim P. Lin
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Patent number: 8968280Abstract: Methods and systems for controlling selective targeting of retinal pigment epithelium (RPE) cells within a treatment region of the RPE. The methods include (a) depositing a selected amount of energy on a test region of the RPE; (b) determining an extent to which microcavitation has occurred in the test region; and (c) on the basis of the determination, either depositing the selected amount of energy on the treatment region, or depositing an increased amount of energy on the test region, and repeating steps (b) and (c).Type: GrantFiled: January 22, 2010Date of Patent: March 3, 2015Assignee: The General Hospital CorporationInventors: Charles P. Lin, Clemens Alt, Ho Lee
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Patent number: 8925447Abstract: A grilling belt includes a flexible support having first and second major surfaces, an extruded fluoropolymer layer overlying the first major surface, and a cast or skived fluoropolymer layer overlying the extruded fluoropolymer layer. Another grilling belt can include a support having first and second major surfaces, and a first fluoropolymer film overlying the first major surface. The support can include a first fabric having a first bias angle, and a second fabric laminated to the first fabric and having a second bias angle different from the first bias angle by between 20° and 160°.Type: GrantFiled: June 10, 2011Date of Patent: January 6, 2015Assignee: Saint-Gobain Performance Plastics CorporationInventors: Hua Fan, Anne B. Hardy, Timothy P. Pollock, Ephraim P. Lin
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Publication number: 20140147568Abstract: A cooking release material includes a layer comprising fluoropolymer. The cooking release material has a major surface having nucleation structures in a density of at least 10 per square inch. The cooking release material can include a reinforcement material, the layer coated over the reinforcement material. The cooking release material can include a second layer forming the major surface.Type: ApplicationFiled: January 30, 2014Publication date: May 29, 2014Applicant: SAINT-GOBAIN PERFORMANCE PLASTICS CORPORATIONInventors: Graham A. Woerner, Timothy P. Pollock, Ephraim P. Lin, John M. Russo, Anne B. Hardy, Gerard T. Buss
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Publication number: 20140031647Abstract: The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood vessels are illuminated with radiation so as to cause a multi-photon excitation of an exogenous fluorophore that was previously introduced into the subject to label one or more cell types of interest. In some other embodiments, rather than utilizing an exogenous fluorophore, endogenous (intrinsic) cellular fluorescence can be employed for in vivo flow cytometry. The emission of fluorescence radiation from such fluorophores in response to the excitation can be detected and analyzed to obtain information regarding a cell type of interest.Type: ApplicationFiled: September 30, 2013Publication date: January 30, 2014Applicant: The General Hospital Corporation D/B/A Massachusetts General HospitalInventors: Charles P. Lin, Alicia L. Carlson, Clemens Alt, David P. Biss, Costas M. Pitsillides, Li Chunqiang
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Patent number: 8574859Abstract: The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood vessels are illuminated with radiation so as to cause a multi-photon excitation of an exogenous fluorophore that was previously introduced into the subject to label one or more cell types of interest. In some other embodiments, rather than utilizing an exogenous fluorophore, endogenous (intrinsic) cellular fluorescence can be employed for in vivo flow cytometry. The emission of fluorescence radiation from such fluorophores in response to the excitation can be detected and analyzed to obtain information regarding a cell type of interest.Type: GrantFiled: March 27, 2009Date of Patent: November 5, 2013Assignee: The General Hospital CorporationInventors: Charles P. Lin, Alicia L. Carlson, Clemens Alt, David P. Biss, Costas M. Pitsillides, Chunqiang Li
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Patent number: 8470969Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.Type: GrantFiled: June 23, 2010Date of Patent: June 25, 2013Assignee: Genentech, Inc.Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh, Evan E. Shave, Patricia A. Rancatore
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Patent number: 8425850Abstract: Embodiments describe an arrangement for reducing the amount of LPA that reaches a NOx reducing apparatus such as a SCR system. The arrangement includes deflection elements, screens, means for dislodging any LPA that might become lodged in the screens, an aperture for removing the ash through, hoppers or collection means and an ash conveyance system. The arrangement is positioned in a region of ductwork with a reduced gas flow such as the SCR reactor. The screens are positioned relative to one another to direct the LPA downward toward an aperture for removal. In one embodiment the positioning of the screens creates a half-trough or inverted pyramid appearance when placed next to a vertical wall in the flue gas ductwork or the SCR reactor. The low point of the trough is in communication with the aperture allowing the LPA to exit the flue ductwork.Type: GrantFiled: December 8, 2010Date of Patent: April 23, 2013Assignee: American Electric Power Company, Inc.Inventors: Chao P. Lin, Darren C. Hanby, Jeffery L. Hofacre, Thomas E. McCartney, James Silk
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Patent number: 8366704Abstract: The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.Type: GrantFiled: May 25, 2012Date of Patent: February 5, 2013Assignee: The General Hospital CorporationInventors: Charles P. Lin, Clemens Alt
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Publication number: 20120296320Abstract: The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.Type: ApplicationFiled: May 25, 2012Publication date: November 22, 2012Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Charles P. Lin, Clemens Alt
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Patent number: 8211660Abstract: The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest. In some embodiments, the circulating cells comprise apoptotic cells whose detection can allow, e.g., non-invasive monitoring of the efficacy of a cancer treatment, such as an anti-tumor or an anti-angiogenic therapy.Type: GrantFiled: May 24, 2010Date of Patent: July 3, 2012Assignee: The General Hospital CorporationInventors: Charles P. Lin, Xunbin Wei, Dorothy Sipkins
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Publication number: 20120136258Abstract: The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.Type: ApplicationFiled: January 25, 2012Publication date: May 31, 2012Applicant: The General Hospital Corporation D/B/A Massachusetts General HospitalInventors: Charles P. Lin, Clemens Alt, Israel Veilleux, Daniel Cote
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Patent number: 8187257Abstract: The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.Type: GrantFiled: October 31, 2005Date of Patent: May 29, 2012Assignee: The General Hospital CorporationInventors: Charles P. Lin, Clemens Alt
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Patent number: 8185078Abstract: A system and method for implementing dynamic spur avoidance in a high speed receiver environment is provided. For a plurality of radio frequency (RF) input signal ranges, a range of intermediate frequency (IF) signals and a noise floor for each IF signal is determined. An identification of spurs that will affect the noise floor is also determined from a look up table for each range of the RF inputs. A frequency plan that sets local oscillator and constituent oscillator signals is selected such that the IF signals generated from the RF input will avoid lower order spurious responses of the identified spurs within the IF signal range.Type: GrantFiled: October 22, 2009Date of Patent: May 22, 2012Assignee: Anritsu CompanyInventors: Jon S. Martens, Oggi P. Lin, Thomas J. Albrecht, Peter A. Kapetanic
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Patent number: 8178342Abstract: The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest.Type: GrantFiled: January 7, 2009Date of Patent: May 15, 2012Assignee: The General Hospital CorporationInventor: Charles P. Lin
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Publication number: 20120029490Abstract: Methods and systems for controlling selective targeting of retinal pigment epithelium (RPE) cells within a treatment region of the RPE. The methods include (a) depositing a selected amount of energy on a test region of the RPE; (b) determining an extent to which microcavitation has occurred in the test region; and (c) on the basis of the determination, either depositing the selected amount of energy on the treatment region, or depositing an increased amount of energy on the test region, and repeating steps (b) and (c).Type: ApplicationFiled: January 22, 2010Publication date: February 2, 2012Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Charles P. Lin, Clemens Alt, Ho Lee
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Patent number: 8108031Abstract: The present invention provides methods and systems for performing in-vivo flow cytometry to obtain desired information regarding one or more cell types of interest flowing through a subject's circulatory system. In one embodiment of the invention, a portion of the subject's circulating blood is illuminated with radiation having multiple wavelength components, and the backscattered radiation generated in response to the excitation radiation is detected at a plurality of scattering angles and analyzed to derive the desired information.Type: GrantFiled: August 27, 2007Date of Patent: January 31, 2012Assignee: The General Hospital CorporationInventors: Irene Georgakoudi, Charles P. Lin
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Publication number: 20120003729Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: ApplicationFiled: July 1, 2011Publication date: January 5, 2012Applicant: VANDERBILT UNIVERSITYInventors: John P. Wikswo, Franz J. Baudenbacher, Ales Prokop, Eugene J. Leboeuf, Chang Y. Chung, David Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler
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Patent number: D731515Type: GrantFiled: August 14, 2013Date of Patent: June 9, 2015Assignee: BETTER CHINESE, LLC.Inventor: James P. Lin
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Patent number: D733176Type: GrantFiled: August 14, 2013Date of Patent: June 30, 2015Assignee: BETTER CHINESE, LLC.Inventor: James P. Lin