Patents by Inventor A. P. Lin
A. P. Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110303101Abstract: A grilling belt includes a flexible support having first and second major surfaces, an extruded fluoropolymer layer overlying the first major surface, and a cast or skived fluoropolymer layer overlying the extruded fluoropolymer layer. Another grilling belt can include a support having first and second major surfaces, and a first fluoropolymer film overlying the first major surface. The support can include a first fabric having a first bias angle, and a second fabric laminated to the first fabric and having a second bias angle different from the first bias angle by between 20° and 160°.Type: ApplicationFiled: June 10, 2011Publication date: December 15, 2011Applicant: SAINT-GOBAIN PERFORMANCE PLASTICS CORPORATIONInventors: Hua Fan, Anne B. Hardy, Timothy P. Pollock, Ephraim P. Lin
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Publication number: 20110269947Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.Type: ApplicationFiled: June 23, 2010Publication date: November 3, 2011Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh, Evan E. Shave, Patricia A. Rancatore
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Publication number: 20110244523Abstract: The invention provides a novel truncated mutated T4 RNA ligase 2. In addition, methods are provided for ligating pre-adenlylated donor molecules to the 3? hydroxyl group of RNA in the absence of ATP using the ligase.Type: ApplicationFiled: January 30, 2008Publication date: October 6, 2011Applicant: THE ROCKEFELLER UNIVERSITYInventors: Thomas Tuschl, Janos Ludwig, Yi Pei, Carolina P. Lin
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Publication number: 20110245185Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.Type: ApplicationFiled: October 21, 2010Publication date: October 6, 2011Applicant: Genentech, Inc.Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh
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Patent number: 8006702Abstract: A method of scanning a laser beam across a set of cells includes during a first interval, scanning a laser beam across a set of cells; and during a second interval, deflecting the laser beam away from the set of cells. The first interval is selected to cause microcavitation in at least a portion of the cells from the set of cells.Type: GrantFiled: June 2, 2008Date of Patent: August 30, 2011Assignee: The General Hospital CorporationInventor: Charles P Lin
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Patent number: 8003378Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: GrantFiled: March 5, 2009Date of Patent: August 23, 2011Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Ales Prokop, Eugene LeBoeuf, Chang Y. Chung, David E. Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler
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Patent number: 7947036Abstract: A method of scanning a laser beam across a set of cells includes during a first interval, causing a galvanometric scanner to scan a laser beam across a set of cells; and during a second interval, causing the galvanometric scanner to deflect the laser beam away from the set of cells. The first interval is selected to cause microcavitation in at least a portion of the cells from the set of cells.Type: GrantFiled: July 23, 2008Date of Patent: May 24, 2011Assignee: The General Hospital CorporationInventor: Charles P Lin
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Publication number: 20110098014Abstract: A system and method for implementing dynamic spur avoidance in a high speed receiver environment is provided. For a plurality of radio frequency (RF) input signal ranges, a range of intermediate frequency (IF) signals and a noise floor for each IF signal is determined. An identification of spurs that will affect the noise floor is also determined from a look up table for each range of the RF inputs. A frequency plan that sets local oscillator and constituent oscillator signals is selected such that the IF signals generated from the RF input will avoid lower order spurious responses of the identified spurs within the IF signal range.Type: ApplicationFiled: October 22, 2009Publication date: April 28, 2011Applicant: ANRITSU COMPANYInventors: Jon S. Martens, Oggi P. Lin, Thomas J. Albrecht, Peter M. Kapetanic
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Publication number: 20110060232Abstract: The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.Type: ApplicationFiled: May 2, 2008Publication date: March 10, 2011Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Charles P. Lin, Clemens Alt, Israel Veilleux, Daniel Cote
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Publication number: 20110044910Abstract: The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood vessels are illuminated with radiation so as to cause a multi-photon excitation of an exogenous fluorophore that was previously introduced into the subject to label one or more cell types of interest. In some other embodiments, rather than utilizing an exogenous fluorophore, endogenous (intrinsic) cellular fluorescence can be employed for in vivo flow cytometry. The emission of fluorescence radiation from such fluorophores in response to the excitation can be detected and analyzed to obtain information regarding a cell type of interest.Type: ApplicationFiled: March 27, 2009Publication date: February 24, 2011Applicant: THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSEETS GENERAL HOSPITALInventors: Charles P. Lin, Alicia L. Carlson, Clemens Alt, David P. Biss, Costas M. Pitsillides, Chunqiang Li
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Patent number: 7842668Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.Type: GrantFiled: September 29, 2006Date of Patent: November 30, 2010Assignee: Genentech, Inc.Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh
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Publication number: 20100233092Abstract: The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest. In some embodiments, the circulating cells comprise apoptotic cells whose detection can allow, e.g., non-invasive monitoring of the efficacy of a cancer treatment, such as an anti-tumor or an anti-angiogenic therapy.Type: ApplicationFiled: May 24, 2010Publication date: September 16, 2010Applicant: The General Hospital Corporation D/B/A Massachusetts General HospitalInventors: Charles P. Lin, Xunbin Wei, Dorothy Sipkins
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Patent number: 7790443Abstract: A bioreactor with substance injection capability. In one embodiment, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a chamber for receiving cells and a liquid medium. A port is formed in the second substrate between the bottom surface and the first surface of the second substrate. As formed, the port is in fluid communication with the chamber to allow a stream of substance to be introduced into the chamber. The stream of substance is controlled so as to provide a gradient, or a concentration gradient of the substance, to the chamber.Type: GrantFiled: August 27, 2003Date of Patent: September 7, 2010Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Mark A. Stremler, Alissa Weaver
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Patent number: 7763017Abstract: A method of scanning a laser beam across a set of cells includes during a first interval, scanning a laser beam across a set of cells; and during a second interval, deflecting the laser beam away from the set of cells. The first interval is selected to cause microcavitation in at least a portion of the cells from the set of cells.Type: GrantFiled: July 26, 2006Date of Patent: July 27, 2010Assignee: The General Hospital CorporationInventor: Charles P. Lin
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Patent number: 7745155Abstract: The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest. In some embodiments, the circulating cells comprise apoptotic cells whose detection can allow, e.g., non-invasive monitoring of the efficacy of a cancer treatment, such as an anti-tumor or an anti-angiogenic therapy.Type: GrantFiled: July 27, 2005Date of Patent: June 29, 2010Assignee: Massachusetts General HospitalInventors: Charles P. Lin, Xunbin Wei, Dorothy Sipkins
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Patent number: 7741282Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.Type: GrantFiled: November 12, 2002Date of Patent: June 22, 2010Assignee: Genentech, Inc.Inventors: Tanya P. Lin, Zahra Shahrokh, Heather Flores, Roger Pai, Timothy C. Matthews
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Patent number: 7741285Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.Type: GrantFiled: May 24, 2005Date of Patent: June 22, 2010Assignee: Genentech, Inc.Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh
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Publication number: 20100049041Abstract: The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest.Type: ApplicationFiled: January 7, 2009Publication date: February 25, 2010Applicant: THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETS GENERAL HOSPITALInventor: Charles P. Lin
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Publication number: 20090215654Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: ApplicationFiled: March 5, 2009Publication date: August 27, 2009Applicant: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Ales Prokop, Eugene J. Leboeuf, Chang Y. Chung, David Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler
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Patent number: 7534601Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: GrantFiled: August 27, 2003Date of Patent: May 19, 2009Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Alex Prokop, Eugene J. Leboeuf, Chang Y. Chung, David Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler