Abstract: Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that have an up-regulation or a down-regulation in biomarker expression related to angiogenesis and vascular development. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Abstract: A safety system includes a load detection sensor retrofitable on a safety hook, a transmitter arranged to convey a load status signal, processing means for analyzing the load status signal, a receiver for receiving the load status signal and being operably connected to the processing means, warning means arranged to generate notifications, and a power source for providing energy to the transmitter, the receiver, and the processing means. The load detection sensor is arranged to generate a load status signal which is sent by the transmitter to the receiver and then analyzed by the processing means so that when the load status signal indicates that a load is undetected or that the safety hook is connected, the warning means are either inactive or generate a first notification but when the pressure status signal indicates that a load is detected or that the safety hook is disconnected, the warning means generate a second notification.

Abstract: A system is provided including a first elongated object proximate a first surface on a first side of a structure and a second elongated object proximate a second surface on a second side of the structure, the second surface and the second side opposite the structure relative to the first surface and the first side, the first object aligned with the second object at a first point on the first surface. The system also includes a first plurality of corner cubes affixed to the first object at first known distances from each other and from the first point, wherein the first object abuts the first surface at the first point. The system also includes a second plurality of corner cubes affixed to the second object at second known distances from each other and from the first point, wherein the second object abuts second surface at second point opposite first point.

Abstract: Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Abstract: A method of forming a bonded assembly (10). The method comprises: providing at least first and second parts (12, 14) of an assembly (10) to be bonded; assembling the first and second parts (12, 14) in a required relative position to define a bond interface region therebetween; sealing part way along an edge (18) of the bond interface region using laser beam welding to define a cavity between the first and second parts (12, 14); in a vacuum environment, sealing the remainder of the edge (20) of the bond interface region using electron beam welding to form a fluid tight seal around the cavity; and applying heat and pressure to an external surface of the cavity to diffusion bond the first and second parts (12, 14) together.

Abstract: A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful for determining the prognosis of a patient diagnosed with colon cancer, such as stage II colon cancer. The gene signature described herein is also useful for determining effectiveness of surgical resection with or without adjuvant chemotherapy, and determining possibility of cancer recurrence in patients with colon cancer.

Abstract: Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Abstract: Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Abstract: A fire evacuation guidance system includes a pair of dissimilarly colored laser beams generated by at least one laser emitting device. The dissimilarly colored laser beams are generated substantially parallel to hallways of a (5) structure and subsequently reflected, where required, to direct occupants to a shortest exit route in the event of a fire emergency. That is, a first laser beam of one color is generated substantially parallel to one side of a hallway while a second laser beam of a second color different from the first color is generated substantially parallel to the opposite side of the hallway. So long as an occupant (10) of the structure positions himself or herself between the two laser beams and keeps the laser beam of the first color on his or her right hand side, the occupant will be directed to the closest exit in the event of a fire emergency.

Abstract: A system and a method for remotely storing information from portable electronics using a multi-point wireless link. The method and system involves a Bluetooth-enabled camera that communicates to a 3G cellular telephone via a Bluetooth wireless link, the telephone then uses the 3G wireless link to connect to a remote storage device via the Internet. Using this concept, the internal memory of the portable device is used as a buffer memory without needing to be in the vicinity of a computer because the cellular telephone can act as a go between from the portable device to the storage space via the Internet.

Abstract: A fire evacuation guidance system includes a pair of dissimilarly colored laser beams generated by at least one laser emitting device. The dissimilarly colored laser beams are generated substantially parallel to hallways of a (5) structure and subsequently reflected, where required, to direct occupants to a shortest exit route in the event of a fire emergency. That is, a first laser beam of one color is generated substantially parallel to one side or a hallway while a second laser beam of a second color different from the first color is generated substantially parallel to the opposite side of the hallway. So long as an occupant (10) of the structure positions himself or herself between the two laser beams and keeps the laser beam of the first color on his or her right hand side, the occupant will be directed to the closest exit in the event of a fire emergency.

Abstract: The present invention is directed to methods and apparatus that use electrostatic and/or electromagnetic fields to enhance the process of spray forming preforms or powders. The present invention also describes methods and apparatus for atomization and heat transfer with non-equilibrium plasmas. The present invention is also directed to articles, particularly for use in gas turbine engines, produced by the methods of the invention.

Abstract: In one embodiment, a taper tool assembly includes a body, a control sleeve, and at least one bearing surface. The body is configured to hold dry wall compound. The control sleeve is configured to move along at least a portion of a length of the body. The at least one bearing surface is positioned between the body and the control sleeve, the at least one bearing surface reducing friction between the body and the control sleeve.

Abstract: A method for refining and casting metals and metal alloys includes melting and refining a metallic material and then casting the refined molten material by a nucleated casting technique. The refined molten material is provided to the atomizing nozzle of the nucleated casting apparatus through a transfer apparatus adapted to maintain the purity of the molten refined material. An apparatus including a melting and refining apparatus, a transfer apparatus, and a nucleated casting apparatus, in serial fluid communication, also is disclosed.

Abstract: One non-limiting embodiment of an apparatus for forming an alloy powder or preform includes a melting assembly, an atomizing assembly, and a field generating assembly, and a collector. The melting assembly produces at least one of a stream of a molten alloy and a series of droplets of a molten alloy, and may be substantially free from ceramic in regions contacted by the molten alloy. The atomizing assembly generates electrons and impinges the electrons on molten alloy from the melting assembly, thereby producing molten alloy particles. The field generating assembly produces at least one of an electrostatic field and an electromagnetic field between the atomizing assembly and the collector. The molten alloy particles interact with the at least one field, which influences at least one of the acceleration, speed, and direction of the molten alloy particles. Related methods also are disclosed.

Abstract: Various non-limiting embodiments disclosed herein relate to nozzle assemblies for conveying molten material, the nozzle assemblies comprising a body, which may be formed from a material having a melting temperature greater than the melting temperature of the molten material to be conveyed, and having a molten material passageway extending therethrough. The molten material passageway comprises an interior surface and a protective layer is adjacent at least a portion of the interior surface of the passageway. The protective layer may comprise a material that is essentially non-reactive with the molten material to be conveyed. Further, the nozzle assemblies according to various non-limiting embodiments disclosed herein may be heated, and may be self-inspecting. Methods and apparatus for conveying molten materials and/or atomizing molten materials using the nozzle assemblies disclosed herein are also provided.

Abstract: Embodiments of the present disclosure relate to nickel-base alloys and methods of direct aging nickel-base alloys. More specifically, certain embodiments of the present disclosure relate to methods of direct aging 718Plus® nickel-base alloy to impart improved mechanical properties, such as, but not limited to, tensile strength, yield strength, low cycle fatigue, fatigue crack growth, and creep and rupture life to the alloys. Other embodiments of the present disclosure relate to direct aged 718Plus® nickel-base alloy, and articles of manufacture made therefrom, having improved mechanical properties, such as, but not limited to, tensile strength, yield strength, low cycle fatigue, fatigue crack growth, and creep and rupture life.

Abstract: A breathing bag including integrally formed connector portion, distensible bag portion and an inverted truncated conical portion intermediate the connector portion and the distensible bag portion, the connector portion being sufficiently thick or rigid to be connected directly to a male fitting.

Abstract: Embodiments of the present invention relate to nickel-base alloys, and in particular 718-type nickel-base alloys, having a desired microstructure that is predominantly strengthened by ??-phase precipitates and comprises an amount of at least one grain boundary precipitate. Other embodiments of the present invention relate to methods of heat treating nickel-base alloys, and in particular 718-type nickel-base alloys, to develop a desired microstructure that can impart thermally stable mechanical properties. Articles of manufacture using the nickel-base alloys and methods of heat treating nickel-base alloys according to embodiments of the present invention are also disclosed.

Abstract: Embodiments of the present invention relate to nickel-base alloys, and in particular 718-type nickel-base alloys, having a desired microstructure that is predominantly strengthened by ??-phase precipitates and comprises an amount of at least one grain boundary precipitate. Other embodiments of the present invention relate to methods of heat treating nickel-base alloys, and in particular 718-type nickel-base alloys, to develop a desired microstructure that can impart thermally stable mechanical properties. Articles of manufacture using the nickel-base alloys and methods of heat treating nickel-base alloys according to embodiments of the present invention are also disclosed.