Abstract: The present invention relates to regulatory nucleic acid sequences, in particular muscle-specific promoters, elements thereof, and other such nucleic acid sequences, that are capable of enhancing muscle-specific expression of genes. The invention also relates to expression constructs, vectors and cells comprising such muscle-specific regulatory nucleic acid sequences, and to methods of their use. The regulatory nucleic acid sequences are of particular utility for gene therapy applications, but also find utility in other areas such as bioprocessing and biotechnology.

Abstract: Systems or methods of the present disclosure may provide an electronic device that includes memory storing instructions; and a processor, that when executing the instructions, is to receive a design for a programmable fabric of an integrated circuit device. The instructions are also to cause the processor to cause compilation of the design into a configuration during a compilation window. The instructions further are to cause the processor to determine at least some routing for the configuration outside of the compilation window.

Abstract: A filter strip is provided for rolling sheets to construct custom cigars and/or cigarettes. The filter strip may be made of a deformable material which can be positioned on one end of the rolling sheet. The filter strip can be folded in a zig zag or spiral filter section with open section located longitudinally below to form a filter tip. The filter tip can assist the user in rolling by hand a substantially cylindrical or conical cigar or cigarette. The filter tip prevents tobacco filler material from being drawn through the cigar or cigarette and into a user's mouth, and permits the entire amount of tobacco filler to be consumed/smoked without risking burned hands and/or lips.

Abstract: Activity data associated with a fleet move is received. The activity data is associated with performance of activities for one or more events according to a move play prescribed for the fleet move. A plurality of features associated with the activity data are extracted. The extracted features are input into a machine learning model that is trained based on features of historical activity data of historical fleet moves. A probability of the fleet move having the prescribed move play failing to complete within a predetermined timeframe is received as output from the machine learning model. In response to the probability being higher than a threshold, one or more recommendations configured to improve a likelihood of the fleet move being completed within the predetermined timeframe or reduce overtime, are generated. A graphical user interface of a client device is caused to display the one or more recommendations.

Abstract: Embodiments herein are directed to a resonator for an ion implanter. In some embodiments, a resonator may include a housing, and a first coil and a second coil partially disposed within the housing. Each of the first and second coils may include a first end including an opening for receiving an ion beam, and a central section extending helically about a central axis, wherein the central axis is parallel to a beamline of the ion beam, and wherein an inner side of the central section has a flattened surface.

Abstract: The present invention consists of a set of sunglasses used for locating shark teeth on a beach. The invention takes advantage of the way the human brain generates images in order to make shark teeth stand out on the sand. It does so by blocking out specific wavelengths of light that help to accentuate color differences between the teeth and the underlying beach surface. Shark teeth undergo a change of color after falling out that causes them to be differentiable in shade from sand or sediment. By selectively filtering corresponding shades of light, the present invention causes the teeth to stand out as spots on the sand, significantly increasing the ease of spotting and collecting them. When the wavelengths of light reaching the eye are filtered, the shark teeth ultimately stand out as stark dark areas on the beach.

Abstract: Three-dimensional (3D) visualization of multi-layer networks include receiving data associated with a network, wherein the network includes interconnected network elements that operate at a plurality of levels that include any of network layers and encapsulations; displaying a plurality of three-dimensional icons each represent one of a plurality of network elements of the interconnected network elements; and displaying links between the plurality of three-dimensional icons each link representing one of a network layer connection and an encapsulation connection.

Abstract: Devices, systems, and methods for autonomously sorting dirty laundry articles into batched loads for washing are described. For example, an autonomous sorting system includes an enclosed channel including a stationary floor extending between an inlet end and an outlet end of the channel, a plurality of arms disposed in series along the enclosed channel for selectively grasping at least one of the plurality of deformable articles in sequence. The system includes an outlet orifice adjacent the outlet end through which each separated deformable article exits the enclosed channel upon release by the terminal gripper of the one of the plurality of arms, and one or more conveyors disposed adjacent the outlet end configured for receiving thereon a plurality of bins for collecting for washing together two or more articles of the plurality of deformable articles released through the outlet orifice having a common sensor-detected one or more characteristics.

Abstract: The present invention provides methods, compositions and kits for assembling an enzyme-deoxyribonucleic acid (DNA) complex for use in preparing a double stranded DNA molecule comprising one or more loci of interest for determining the methylation status of the one or more loci of interest therein.

Abstract: A multi channel beamsplitter system operating over a wide spectral band has high optical performance despite the fact that the incoming and/or exiting light is not collimated and its material is dispersive. This is achieved using wavefront compensators that are matched to the curvature of the wavefronts of the incoming and/or exiting light.

Abstract: This disclosure provides multimeric binding molecules that specifically and agonistically bind to programmed cell death protein 1 (PD-1). This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating autoimmune disorders and preventing transplantation rejection.

Abstract: An apparatus may include a cyclotron to receive an ion beam as an incident ion beam at an initial energy, and output the ion beam as an accelerated ion beam at an accelerated ion energy. The apparatus may further include an RF source to output an RF power signal to the cyclotron chamber, the RF power source comprising a variable power amplifier, and a movable stripper, translatable to intercept the ion beam within the cyclotron at a continuum of different positions.

Abstract: A drug injection device includes a last dose setting having a main drive pin, a drive wheel, a driven wheel, an abutment element fixedly coupled to, or integrally formed with, the driven wheel. The drive wheel has a rotation axis parallel to a longitudinal axis and is configured to be driven about the longitudinal axis by a knob and to be periodically driven in rotation about the rotation axis by the main drive pin, during a drug dose setting. The driven wheel has a second rotation axis parallel or coaxial to said longitudinal axis and is configured to be periodically driven about the longitudinal axis by the drive wheel. The abutment element is configured to prevent the rotation of the drive wheel about the longitudinal axis when the knob has made a predetermined number of full and/or partial rotations about the longitudinal axis correlated to the predetermined drug volume.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: Devices, systems, and methods for autonomously folding a deformable laundry article are described. A folding device includes a rotatable platform configured to receive the article. A rotatable blade is suspended above the surface and a clamp rod is disposed parallel to a longitudinal axis of the blade. The clamp rod is configured to raise and lower from a surface of the rotatable platform, slidably move parallel to the surface, and clamp the deformable article to the surface in a lowered position. The blade is configured to raise and lower from the surface of the rotatable platform, slidably move parallel to the surface, slide under an unclamped portion of the article, lift the unclamped portion above the clamp rod, pass the unclamped portion over the clamp rod, and lower the free end to a resting position atop another portion of the article to fold the article.

Abstract: A system comprising a spinning disk is disclosed. The system comprises a semiconductor processing system, such as a high energy implantation system. The semiconductor processing system produces a spot ion beam, which is directed to a plurality of workpieces, which are disposed on the spinning disk. The spinning disk comprises a rotating central hub with a plurality of platens. The plurality of platens may extend outward from the central hub and workpieces are electrostatically clamped to the platens. The plurality of platens may also be capable of rotation. The central hub also controls the rotation of each of the platens about an axis orthogonal to the rotation axis of the central hub. In this way, variable angle implants may be performed. Additionally, this allows the workpieces to be mounted while in a horizontal orientation.

Abstract: A sensor device is described herein. The sensor device includes a multi-dimensional optical sensor and processing circuitry, wherein the multi-dimensional optical sensor generates images and the processing circuitry is configured to output data that is indicative of hemodynamics of a user based upon the images. The sensor device is non-invasive, and is able to be incorporated into wearable devices, thereby allowing for continuous output of the data that is indicative of the hemodynamics of the user.

Abstract: Methods and apparatus for performing profile-guided optimization of integrated circuit hardware are provided. Circuit design tools may receive a source code and compile the source code to generate a hardware description. The hardware description may include profiling blocks configured to measure useful information required for optimization. The hardware description may then be simulated to gather profiling data. The circuit design tools may then analyze the gathered profiling data to identify additional opportunities for hardware optimization. The source code may then be modified based on the analysis of the profiling data to produce a smaller and faster hardware that is better suited to the application.

Abstract: This disclosure provides therapeutic methods for treating cancer including combination therapy with a multimeric anti-DR5 antibody and a cancer therapy, e.g., radiation, an anthracycline, a folic acid analog, a platinum-based agent, a taxane, a topoisomerase II inhibitor, a SMAC mimetic, a vinca alkaloid, a Brutons tyrosine kinase (BTK) inhibitor, a phosphoinositide 3-kinase delta (PI3K?) inhibitor, a myeloid cell leukemia-1 (Mcl-1) inhibitor, or any combination thereof.

Abstract: The disclosed system may include (1) a drive subsystem that translates along a powerline conductor, (2) a rotation subsystem that rotates a segment of fiber optic cable about the powerline conductor while the drive subsystem translates along the powerline conductor such that the segment of fiber optic cable is wrapped helically about the powerline conductor, and (3) an extension subsystem that (a) mechanically couples the rotation subsystem to the drive subsystem, and (b) selectively extends the rotation subsystem away from the drive subsystem and the powerline conductor to avoid obstacles along the powerline conductor. Various other systems and methods are also disclosed.