Abstract: The present invention relates to regulatory nucleic acid sequences, in particular CNS—specific promoters, and elements thereof. The invention also relates to expression constructs, vectors, virions, pharmaceutical compositions and cells comprising such promoters and to methods of their use. The regulatory nucleic acid sequences are of particular utility for gene therapy applications.

Abstract: Devices, systems, and methods for autonomously sorting dirty laundry articles into batched loads for washing are described. For example, an autonomous sorting device includes an enclosed channel including a plurality of sequential work volumes and a stationary floor extending between an inlet end and an outlet end of the channel, a plurality of arms disposed in series along the enclosed channel for rotating, tilting, extending, and retracting a terminal gripper of each arm into an associated work volume for grabbing at least one of a plurality of deformable dirty laundry articles and passing the at least one deformable laundry article to an adjacent work volume for grasping and hoisting by an adjacent arm. The device includes an inlet orifice for receiving the dirty laundry articles into the enclosed channel and an outlet orifice adjacent the outlet end through which each separated deformable article exits the enclosed channel into sorting bins.

Abstract: A load lock in which the pumping speed is controlled so as to minimize the possibility of condensation is disclosed. The load lock is in communication with a vacuum pump and a valve. A controller is used to control the valve such that the supersaturation ratio within the load lock does not exceed a predetermined threshold, which is less than or equal to the critical value at which vapor condenses. In certain embodiments, a computer model is used to generate a profile, which may be a pumping speed profile or a pressure profile, and the valve is controlled according to the profile. In another embodiment, the load lock comprises a temperature sensor and a pressure sensor. The controller may calculate the supersaturation ratio based on these parameters and control the valve accordingly.

Abstract: A honey bee mite removal device includes a chamber having a one-way entry gate opposing an exit gate. An electronics puck is positioned within the chamber as well as a fondant to entice honey bees to enter the chamber through the one-way entry gate. There is also a dusting assembly within the chamber adjacent to the exit gate to dispense dusting powder onto the honey bees so that the honey bees groom themselves dislodging any mites that are attached to the honey bees.

Abstract: An exciter for a high frequency resonator. The exciter may include an exciter coil inner portion, extending along an exciter axis, an exciter coil loop, disposed at a distal end of the exciter coil inner portion. The exciter may also include a drive mechanism, including at least a rotation component to rotate the exciter coil loop around the exciter axis.

Abstract: Embodiments herein are directed to a linear accelerator assembly for an ion implanter. In some embodiments, a LINAC may include a coil resonator and a plurality of drift tubes coupled to the coil resonator by a set of flexible leads.

Abstract: Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions

Abstract: An ion source including a chamber housing defining an ion source chamber and including an extraction plate on a front side thereof, the extraction plate having an extraction aperture formed therein, and a tubular cathode disposed within the ion source chamber and having an opening formed in a front half thereof nearest the extraction aperture, wherein a rear half of the tubular cathode furthest from the extraction aperture is closed.

Abstract: A method of neurostimulation includes applying a probe signal to an electrode implanted in or near a target neural structure of the brain. The method further includes detecting a first response from the target neural structure evoked by the probe signal and determining a first time period between application of the probe signal and a first temporal feature of the response. Further, the method includes generating a therapeutic signal comprising a plurality of pulses, at least two of the plurality of pulses separated by the first time period, and applying the therapeutic signal to the electrode or another electrode implanted in or near the target neural structure.

Abstract: A propulsion system for a marine vessel in a body of water includes an water intake formed in the hull, a impeller disc rotatable about a vertical axis for raising water and increasing the momentum of water in a plenum chamber, and a plurality of control gates located around the periphery of the hull. The impeller disc has a large outer diameter and is formed to enable efficient rotation by an electric motor. One or more of the water intake, the plenum chamber, the impeller disc and the control gates is designed to reduce acoustic noise generated by the marine vessel, direct the acoustic noise to avoid broadband acoustic noise, increase efficiency of the propulsion system and provide additional safety to passengers on the marine vessel and marine life in the body of water.

Abstract: The present concepts relate to devices that can employ graspable controllers that can be employed in various scenarios, such as virtual reality scenarios and augmented reality scenarios. One example device can include multiple expansion assemblies having independently adjustable girths. The multiple expansion assemblies can be stacked adjacent to one another along an axis. A controller can be configured to expand or contract the girths of the expansion assemblies to collectively approximate girths of an object.

Abstract: A polycrystalline diamond element includes a polycrystalline diamond table having a body of bonded diamond particles with interstitial regions. A first volume of the body includes an interstitial material and a second volume of the body has a lower concentration of interstitial material within the interstitial regions than the first volume. The polycrystalline diamond element includes an element face and a peripheral surface. The first volume is adjacent to a central portion of the element face and the second volume is adjacent to the peripheral surface. A method of processing a polycrystalline diamond element includes forming a concave region in the polycrystalline diamond element, exposing at least a portion of the concave region to a leaching solution, and removing at least a portion of the polycrystalline diamond element that was exposed to the leaching solution from the polycrystalline diamond element.

Abstract: A coil inductor for use with a LINAC is disclosed. The coil inductor comprises one or more tubes, wherein each tube comprises an interior support structure to strengthen the tubes. By supporting the tube, the amount of vibration is reduced, allowing the coil to resonate at its natural frequency. In some embodiments, the interior structure comprises one or more interior walls. These interior walls may be used to create a plurality of fluid channels that allow the flow of coolant through the tubes. An end cap may be disposed on the second end of the tubes to allow fluid communication between the supply fluid channels and the return fluid channels. The first ends of the one or more tubes may be connected to a manifold that includes a supply port and a return port for the passage of coolant.

Abstract: Stabilization mechanisms may include at least one gripper mounted to a powerline-crawling robot, which may be configured to grasp a powerline supporting the powerline-crawling robot. At least one controller may be configured to control a lateral position of the at least one gripper. At least one inertial measurement unit may be configured to sense at least one of lateral movement and axial rotation of the powerline-crawling robot. The controller may control the lateral position of the gripper based on data from the inertial measurement unit. Various other related systems, devices, mechanisms, and methods are also disclosed.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The invention concerns a building system for building a structure such as a dwelling, garage, shop, school, hall or the like comprising a number of interconnecting components whose assembly is dictated by their size and shape, the invention extends to components of said building system; a kit of parts thereof; and a method for building dwellings, garages, shops, schools, halls or the like.

Abstract: The present invention relates to methods for detecting the presence or absence of Parkinson's disease (PD).

Abstract: The present invention relates to methods for identifying high molecular mass lipids in samples. Such high molecular mass lipids may be useful as biomarkers for the identification of disease.

Abstract: A system and method for rendering tactile interaction using an ultrasound transducer array by receiving a target field; computing one or more paths of pressure focal points of varying intensity such that the difference between a result field produced by the one or more paths of pressure focal points and the target field is minimized; and controlling an ultrasound transducer array in spatiotemporal modulation mode to simultaneously render the one or more computed paths of pressure focal points. The system and method for rendering tactile interaction using an ultrasound transducer array accurately represents dynamic interactions produced in a virtual environment with a varying pressure or force field.