Abstract: A filter system includes a housing having an inlet opening surrounded by a sealing surface, an outlet opening. The housing may be rotational molded or be configured to be nestable with additional housings for shipping purposes. The system may also be configured such that the filter to be mounted therewith can be placed interior to the filter housing during shipment. A V-bank filter or a single-header box filter is positioned in the inlet opening, has a flange in general alignment with the sealing surface, and a plurality of filter media sections projecting away from the flange and into the housing interior. A seal is disposed between the flange of the V-bank or single-header box filter and sealing surface. A pre-filter, such as a panel filter, may be provided upstream from the primary filter.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The invention relates to methods and kits for measuring enzyme activity, including enzymes that produce nicotinamide.

Abstract: A processing apparatus comprises a beeper system for controlling operation of a beeper in response to beeper control signals, an audio system for controlling operation of at least one speaker in response to audio data signals, and a redirection module for redirecting a beeper control signal to the audio system.

Abstract: The present invention relates generally to an environmental control unit for use in air handling systems that provides highly effective filtration of noxious gases (such as ammonia). Such a filtration system utilizes novel metal-doped silica-based gels to trap and remove such undesirable gases from an enclosed environment. Such gels exhibit specific porosity requirements and density measurements. Furthermore, in order for proper metal doping to take effect, such gels must be treated while in a wet state. The combination of these particular properties and metal dopant permits highly effective noxious gas filtration such that uptake and breakthrough results are attained, particularly in comparison with prior silica gel filtration products. Also included is the presence of an oxidizing agent (either in reduced or pre-deuced form) to aid in capturing nitrogen dioxide and preventing conversion of such a product to NO. Methods of using and specific filter apparatuses are also encompassed within this invention.

Abstract: Environmental control in air handling systems that are required to provide highly effective filtration of noxious gases particularly within filter canisters that are ultrasonically welded enclosures is provided. In one embodiment, a filtration system utilizes a novel zeolite material that has been hardened to withstand ultrasonic welding conditions in order to reduce the propensity of such a material to destabilize and/or dust. Such a hardened zeolite thus enables for trapping and removal of certain undesirable gases (such as ammonia, ethylene oxide, formaldehyde, and nitrous oxide, as examples) from an enclosed environment, particularly in combination with metal-doped silica gel materials.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

Abstract: The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

Abstract: The invention relates to modulation of SIRT3 activity levels. The invention has applications for regulating metabolism and mimicking caloric restriction or exercise in a muscle cell.

Abstract: A shipping and display carton is provided that may be used for panel filters. The carton preferably has three display positions including horizontally flat, vertically upright, and side filter display positions to provide a retailer with display options. The box has several features such as releasable interlocked retainer flaps to retain filters in one display position, perforated removal portions including a removable card carrying a cover lid, a single glue seam with interlocking bottom panels so as to provide break down without a cut knife, and other features.

Abstract: A hardware encryption device comprises: a touch panel controller; and a cryptographic engine in communication with the touch panel controller. The touch panel controller receives co-ordinates from the cryptographic engine corresponding to an area on a touch panel selected by a user. The cryptographic engine is operable to discriminate between a selection in a secure area on a screen and a selection in a non-secure area on a screen, and to action the selection differently depending on whether the selection is in a secure area or a non-secure area.

Abstract: Provided herein are methods and compositions relating to sirtuin modulation of Wnt pathway signaling, including the use of sirtuin and sirtuin-modulating agents in the prevention and treatment of cancer and other diseases.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: A shipping and display carton is provided that may be used for panel filters. The carton preferably has two display positions including horizontally flat and vertically upright positions to provide a retailer with display options. The box has several features such as releasable interlocked retainer flaps to retain filters in one display position, perforated removal portions including a removable card carrying a cover lid, a single glue seam with interlocking bottom panels so as to provide break down without a cut knife, and other features.

Abstract: The invention relates to a method of controlling access to a processing device using an access token with a machine readable identity. The method comprises reading the identity of the access token at the location of the processing device and querying a database comprising valid identities of access tokens, wherein each identity is associated with an access permission level. If the identity is a valid identity, the method further comprises determining the associated level of access and allowing a level of access to the processing device according to the associated access permission level. In some embodiments, the processing device is an Automated Teller Machine (ATM).

Abstract: New silica gel materials and novel methods of producing such are provided. The method itself entails a manner of mixing the reactants together in a one-pot process such that the time required for aging is reduced without compromising the ability to target pore size production. In such a way, the pH of the reaction drives pore size development, thereby permitting a more efficient process to be followed in terms of expensive drying/heating steps being reduced timewise, if not altogether. Furthermore, in one embodiment, the resultant gel materials exhibit a certain pore size minimum while simultaneously exhibiting a degree of softness heretofore unavailable. As such, not only is this novel method more efficient in silica gel manufacture, but the resultant materials are completely novel as well. The gel materials made therefrom may be utilized in a variety of different end uses, such as cooking oil filtration, soft skin cleansers, dental abrasives, and the like.

Abstract: The present invention provides methods and compositions for improving the health of subjects, such as their resistance to stress.