Abstract: The technology relates generally to the field of immunology and relates in part to T cell compositions and methods for treating diseases and disorders associated with the presence of tumor cells that express prostate stem cell antigen.

Abstract: A behavior detection system has access to a collection of behavior definitions that each describe a functional behavior of a system. Each behavior definition includes multiple basic operations, each of which includes an identifier and one or more parameters. The behavior definition also includes, explicitly or inherently, a basic operation combination definition that describes a sequence or other manner in which the basic operations are combined. The behavior detection system analyzes events in an event log for the system and determines whether the events in the event log satisfy any of the behavior definitions. An appropriate responsive action is taken in response to detecting that the events in the event log satisfy a behavior definition. The collection of behavior definitions is scalable, allowing behavior definitions to be added or deleted, and allowing basic operations in a behavior definition to be changed (e.g., adding, removing, and/or modifying basic operation parameters).

Abstract: Techniques for automated detection and mitigation of subdomain takeovers are described. A method for automated detection and mitigation of subdomain takeovers comprises receiving, by a subdomain manager, a request to monitor one or more resources associated with one or more mapping records, periodically scanning each resource from the one or more resources, receiving a response from at least one resource indicating that the at least one resource does not exist or is invalid, and sending a notification indicating that the at least one resource does not exist or is invalid using a notification service.

Abstract: The technology relates generally to the field of immunology and relates in part to methods for activating cells, including for example T cells and T cells that express chimeric antigen receptors, using an inducible chimeric polypeptide including CD40, MyD88, or CD40 and MyD88 polypeptides. The technology further relates in part to therapeutic methods for inducing an immune response and treating tumors in a patient.

Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Abstract: We disclose various improvements for compositions of genetically-modified T cells which include a suicide switch. For instance, the composition may comprise CD4+ T cells and CD8+ T cells, wherein the ratio of CD4+ T cells to CD8+ T cells is less than 2.

Abstract: An appliance includes a temperature control system, a light source, and a spectrometer. The spectrometer works in conjunction with the light source to obtain a measured value of a foodstuff. The measured value is at least one of an absorbance value, a transmittance value, and a reflectance value. The measured value from the foodstuff is compared to a reference value for the foodstuff.

Abstract: A method includes allocating an identifier to each of a plurality of policies each comprising a network-isolation identifier associated with a VXWAN directive and transmitting each of the plurality of policies to one or more devices in a network.

Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Abstract: The technology relates generally to the field of immunology and relates in part to methods for activating T cells and other cells resulting in an immune response against a target antigen. The technology also relates to costimulation of therapeutic cells that express chimeric antigen receptors that recognize target antigens using chimeric MyD88- and CD40-derived polypeptides. The technology further relates in part to therapeutic cells that express chimeric antigen receptors, wherein the chimeric antigen receptors have an endodomain that includes MyD88- and CD40-derived polypeptides, and methods for treating patients using the modified therapeutic cells.

Abstract: A method of predicting behavior or a degradable device of a borehole tool when deployed downhole including introducing a test mass of material identical to the material of the degradable device to the same general location and at a time near to when the degradable device is deployed, removing the test mass from downhole, determining characteristics related to degradation of the test mass, and predicting degradation behavior of the degradable device based on the determined characteristics.

Abstract: An appliance includes a temperature control system, a light source, and a spectrometer. The spectrometer works in conjunction with the light source to obtain a measured value of a foodstuff. The measured value is at least one of an absorbance value, a transmittance value, and a reflectance value. The measured value from the foodstuff is compared to a reference value for the foodstuff.

Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Abstract: A method includes allocating an identifier to each of a plurality of policies each comprising a network-isolation identifier associated with a VXWAN directive and transmitting each of the plurality of policies to one or more devices in a network.

Abstract: A heat exchanger includes an inlet for receiving bulk solids, a plurality of heat transfer plate assemblies, a plurality of spacers disposed between adjacent heat transfer plate assemblies, and supports for supporting the heat transfer plate assemblies. The heat transfer plate assemblies include a first plate having a first pair of holes extending therethrough, the first plate having channels extending along a surface thereof, for the flow of fluid through the channels, and a second plate bonded to the first plate to enclose the channels, the second plate including a second pair of holes generally aligned with the first pair of holes to form through holes to facilitate flow of the fluid through the through holes and the channels.

Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.

Abstract: A paperboard carrier suitable for use with textiles may include one or more strips of paperboard secured together to form a hollow tubular body, the body having an outer surface, and a coating covering some or all of the outer surface. The coating comprises a coating agent such as a silicon resin dispersed in a solvent such as isopropyl alcohol and little or no water. The coating may be applied to the outer surface by using a plurality spray nozzles arranged axially or circumferentially about the carrier.

Abstract: The technology relates generally to the field of immunology and relates in part to compositions and methods for activating cells, including, for example T cells that express chimeric antigen receptors or recombinant TCRs, and reducing cytotoxicity, using chimeric polypeptides including MyD88 and signaling domains of receptor mediators of costimulation.

Abstract: A paperboard carrier suitable for use with textiles may include one or more strips of paperboard secured together to form a hollow tubular body, the body having an outer surface, and a coating covering some or all of the outer surface. The coating comprises a coating agent such as a silicon resin dispersed in a solvent such as isopropyl alcohol and little or no water. The coating may be applied to the outer surface by using a plurality spray nozzles arranged axially or circumferentially about the carrier.