Abstract: Methods and apparatus for additive manufacturing using extrusion and curing, and for multi-material spatially-modulated extrusion-based additive manufacturing are described, in which material composition and/or color can be varied locally to create abrupt transitions or controlled gradients, and in which objects may be fabricated from thermoset materials.

Abstract: The invention provides an open-stage near-TIRF microscope in which all of the optical components are positioned underneath the sample, allowing for physical access to, and control over the environment of, the sample. The microscope can be used to image cells expressing fluorescent voltage indicators. Since the TIRF components do not interfere with the sample, living cells can be studied using a microscope of the invention. Where a sample includes electrically active cells expressing fluorescent voltage indicators, the microscope can be used to view voltage changes in, and thus the electrical activity of, those cells.

Abstract: Methods and apparatus for automatically preparing food for consumption in which preparation comprises dispensing, manipulation, heating, and other operations using a wide variety of ingredients. The methods and apparatus described use ingredients efficiently and maintain their quality, while avoiding contact between ingredients and apparatus to minimize the risk of system contamination.

Abstract: Various systems, mediums, and methods may involve a data engine with various components. For example, a system with the data engine may include a segmentation component, an asset preparation component, a clustering component, a variable generation component, and classification component. As such, the system may determine a number of assets associated with a number of activities of one or more accounts. Further, the system may determine various links associated with the number of assets. As such, the system may detect an attack and/or an attack trend associated with the one or more accounts based on the various links associated with the number assets. Further, the system may generate a notification that indicates the attack and/or the attack trend detected.

Abstract: Rapidly handling large data sets can be a challenge, particularly in situations where there are millions or even hundreds of millions of database records. Sometimes, however, a service level agreement necessitates that a service return a response to a query in a small amount of time. Database organization techniques can be used that reduce potentially large datasets to smaller groups (neighbors) based on uncommon but shared attributes, in various instances. Using a limited set of related records, queries can be answered using a focused approximation based on characteristics of various identified clusters of records in the set of related records. A particular record may also be associated with an existing cluster of records based on that record's similarities to records in the cluster.

Abstract: For each event detected during execution of a monitored application comprising a plurality of application components, a determination is made of which of the plurality of application components corresponds to the detected event. Also, a dependency subgroup that includes the application component that corresponds to the detected event is identified, wherein a dependency subgroup indicates dependencies among a subgroup of the plurality of application components. A location within the dependency subgroup of the application component corresponding to the detected event is determined. An order of correction for the application components determined to correspond to detected events are determined based, at least in part, on the determined location. Correction of the application components determined to correspond to detected events are initiated according to the determined order of correction.

Abstract: The invention relates to methods of assessing communication between cells. Methods of the invention use optical reporters of cellular electrical activity to evaluate signal propagation between cells and can be used to study an individual synapse or a complex network of interconnected cells. Aspects of the invention provide a method for characterizing signal propagation between cells. The method includes providing a first cell containing a light-generating reporter and a second cell, in which the first cell and the second cell are in communication. The second cell may contain an optical actuator of cellular electrical activity. The second cell is exposed to a stimulus and an optical signal from the first cell is detected.

Abstract: A dependency graph is created that indicates dependencies among a plurality of components of an application based, at least in part, on interactions among the plurality of components determined from at least one execution of the application. In response to selection of a first attribute of a plurality of attributes, the plurality of components are differentiated into a first plurality of sets of the plurality of components based, at least in part, on having values in common for the first attribute. Dependencies among the first plurality of sets of components are determined based, at least in part, on the dependency graph. A first attribute based perspective of the application is determined, wherein the first attribute based perspective comprises a graphical container for each of the first plurality of sets of components and graphical connections between the graphical containers corresponding to the dependencies among the first plurality of sets of components.

Abstract: In one example, a device includes one or more processors, a presence-sensitive display, and a storage device that stores one or more modules. The modules are executable to, responsive to receiving an indication of a first user input: output, for display, a graphical element including at least one task shortcut from a plurality of task shortcuts for an application, receive an indication of a second user input that selects a particular task shortcut included in the graphical element, and, responsive to receiving the indication of the second user input, output, for display, a shortcut icon for the particular task shortcut within the graphical user interface.

Abstract: The invention generally relates to optical methods for the diagnosis of neuronal condition by converting a cell from a patient into a neuron and optically evaluating action potentials of that cell in vitro. The cell is transformed with an optical reporter and exhibits an optical signature in response to neural stimulation. Using genome-editing, a control cell can be made that is isogenic but-for a known mutation and a control signature obtained from the control cell. Thus, methods of the invention reveal potential neurodegenerative effects of a mutation as manifested in a patient's genetic context.

Abstract: Devices, systems, and methods for matching distributed energy consumer preferences with distributed energy investor preferences are disclosed. In one aspect a computerized method comprises receiving preference-related data associated with a distributed energy consumer, determining a preference profile for the consumer, creating a personalized distributed energy asset for the consumer, and bundling the personalized distributed energy assets into a bundle of distributed energy assets. In another aspect the method comprises receiving preference-related data associated with a distributed energy investor, determining a preference profile for the investor, and matching the bundle of distributed energy assets with the investor.

Abstract: A system for robotic device control and data acquisition, comprising a robotic device control system adapted to receive sensor-based data comprising physical object information, the sensor-based data being received from a plurality of sources, each source comprising at least a physical sensor in communication with the robotic device control system computer via a communications network, an enhanced robotic device control application adapted to receive sensor-based data from the robotic device control system computer and manipulate the sensor-based data to produce enhanced data, and a method for robotic device control and data acquisition.

Abstract: The invention generally relates to optical methods for the diagnosis of neuronal condition by converting a cell from a patient into a neuron and optically evaluating action potentials of that cell in vitro. The cell is transformed with an optical reporter and exhibits an optical signature in response to neural stimulation. Using genome-editing, a control cell can be made that is isogenic but-for a known mutation and a control signature obtained from the control cell. Thus, methods of the invention reveal potential neurodegenerative effects of a mutation as manifested in a patient's genetic context. The optical signature of the cell, or the difference between the signature and the control signature, is correlated to a diagnosis of the neurodegenerative disease.

Abstract: A point cloud system having two separate sets of points, each of these sets having different points of view, creating data with potentially occluded points in the point cloud. An accelerated approach of close sister points is used to determine which occluded points can be removed by looking out from an assumed non-occluded point, then finding the closest point in the next set of points, then looking back into the first set of points, or jumping to the closest not occluded point and looking back, and if this second sister is close to initial point, it is a close sister.