Abstract: The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.

Abstract: The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.

Abstract: Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, are novel LXR ligands and are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.

Abstract: The instant invention is concerned with aryl and heteroaryl acetic acid and oxyacetic acid compounds, which are useful as antidiabetic compounds. Compositions and methods for their use in the treatment of diabetes and related diseases and for lowering triglyceride levels are disclosed.

Abstract: A method and system for delivering and securing computer game content via the Internet provides a customized interface from which an end-user may purchase episodic game content wherein game content is secured to the user's computer. A computer game interface lists game episodes that are installed on the end-user's computer, as well as episodes that are available that have not been purchased by the end-user. The episodes that are installed may be started from the interface and episodes that are not installed may be purchased through the interface. Upon purchase of the game, a security mechanism communicates information that uniquely identifies the end-user's computer to a server that then customizes the software before transmitting it to the end-user's computer. The customization provides protection for game software publishers from unauthorized copying and use of the game content.

Abstract: A method of cross-linking a tissue, comprising treating the tissue under effective cross-linking conditions with a fluid comprising a compound comprising P(CH2OH)3Xn, wherein X is selected from C1-C10 carboxyl, sulfonic acid, sulfonic acid salts, C1-C10 alcohol, or halogens, and n is an integer from 0 to 2, inclusive, and all —X and —CH2OH groups are bonded to the phosphorus atom. In one embodiment, the compound is &bgr;-(tris(hydroxymethyl)phosphino)proprionic acid (THPP).

Abstract: The present invention provides a method and apparatus for forming a plurality of parts, such as spade-type boring bits, from a continuous stock material. Thus, the various steps of the forming method of the present invention can be performed to predetermined portions of the continuous stock material prior to separating the continuous stock material into discrete parts, thereby enhancing the efficiency of the forming process. The present invention also provides an improved forge for forming portions of the continuous stock material into parts having a predetermined shape. The forge can be designed to provide a clearance region proximate the forward end of the ram to permit slight flexing of the forward end of the ram in a radially outward direction during forging operations. The forge can also include a lubrication system for lubricating its various components. In addition, the forge can incrementally rotate the ram after one or more parts have been forged.

Abstract: The instant invention is concerned with aryl and heteroaryl acetic acid and oxyacetic acid compounds, which are useful antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and related diseases and for lowering triglyceride levels are also disclosed.

Abstract: The spade-type boring bit includes an elongate shank defining a central longitudinal axis and a blade portion joined to one end of the shank. The blade portion includes a pair of generally flat side segments extending laterally from the central longitudinal axis and having a respective forward cutting edge and a respective chamfered corner portion. Each chamfered corner portion includes a chamfered edge which extends both axially rearward and laterally outward from the respective forward cutting edge so as repeatedly cut the peripheral wall of the resulting hole as the spade bit is rotatably advanced through a workpiece. The spade bit therefore produces a high-quality hole having a smooth peripheral wall and relatively clean entry and exit points. In addition, the forward cutting edges of the spade bit can be aligned with each other along a centerline which passes through the central longitudinal axis of the elongate shaft so as to increase the efficiency with which the spade bit drills.