Abstract: The invention relates to benzodiazepine derivatives of formula (A) useful as CCK2/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK2/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders.

Abstract: Systems and methods that enable user space processing threads to handle hardware events (e.g., page faults) for another processing thread in a security-enhanced manner. An example method may comprise: associating, by a processing device executing a kernel, a first processing thread with a storage unit of a second processing thread; detecting, by a processing device, a hardware event corresponding to an address of the storage unit; determining a storage object comprising data of the storage unit; translating the address of the storage unit to an offset of the storage object; and transmitting, by the kernel, a notification of the hardware event to the first processing thread, wherein the notification comprises the offset.

Abstract: Multi-target post-copy guest migration is disclosed. For example, first, second, and third host nodes are associated with respective first, second, and third memories and respective first, second, and third isolated guest managers. An isolated guest, previously migrated from the first host node, executes on the second host node with a first memory page in the first memory and second and third memory pages in the second memory. The isolated guest is requested to migrate to the third host node. The isolated guest executes on the third host node after the third memory page is migrated. The isolated guest requests the first memory page. The third memory is determined to lack the first memory page, and in response, the first and second isolated guest managers are notified that the first memory page is required by the third host resulting in the first memory page being sent to the third host.

Abstract: A video capture device may include multiple cameras that simultaneously capture video data. The video capture device and/or one or more remote computing resources may perform video stabilization to the video data to reduce unwanted camera shake. The video capture device may include one or more motion sensors that track the motion of the video capture device. Using the motion data, video stabilization algorithms can be executed on a first video stream to calculate stabilizing adjustments for the video stream. The stabilization adjustments can then be used to stabilize a second video stream due to the fixed positioning of a first camera that captured the first video stream and a second camera that captured the second video stream. The video capture device and/or the remote computing resources may stitch together the first and second video streams to generate a digitally stabilized panoramic video.

Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

Abstract: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.

Abstract: The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I)

Abstract: The invention relates to benzodiazepine derivatives of formula (A) useful as CCK2/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK2/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders.

Abstract: Some aspects of the present disclosure provide methods, compositions and kits for identifying one or more reagents, such as a culture medium, that are effective for recombinant protein production.

Abstract: The present invention pertains to a cell culture medium comprising manganese as a media supplement, which was shown to control recombinant protein glycosylation and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.

Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

Abstract: Various examples are directed to providing thermal management to a computing device. The computing device may receive temperature state data describing a temperature state of the computing device. The temperature state may comprise a first temperature value at a first location at the computing device. The computing device may also receive use state data describing a first use state of the computing device. The first use state may comprise an initial operating condition of a first component of the computing device and an initial operating condition of a second component of the computing device. The computing device may determine that at least one temperature value at the computing device is out-of-range and select a second use state for the computing device. The second use state may comprise at least one of a new operating condition for the first component or a new operating condition of the second component.

Abstract: Devices, systems and methods are disclosed for improving encoding techniques for mobile devices by adaptively controlling a resolution or frame rate of content to reduce power consumption while maintaining image quality. For example, a local device may determine when the content may be downscaled without degrading a final image quality and may downscale the content prior to encoding and transmitting the encoded content to a remote device. The remote device may decode and upscale the content to the original resolution prior to displaying the content on a display. As downscaling the content is not power intensive, the local device may reduce a power consumption associated with encoding and transmitting the content to the remote device while maintaining the final image quality of the content.

Abstract: Methods, systems, and computer program products are included for migrating a virtual machine. An example method of migrating a virtual machine includes transmitting, from a hypervisor, a migration indicator to a guest. The hypervisor receives a free memory page indicator from the guest that identifies one or one or more free memory pages corresponding to a virtual machine. The hypervisor then places the virtual machine in a suspended state. While the virtual machine is in the suspended state, the hypervisor modifies a dirty status and a migration status corresponding to one or more dirty memory pages. After resuming operation of the virtual machine from the suspended state, the hypervisor modifies a migration status corresponding to the one or more free memory pages to exclude the one or more free memory pages from a migration. The hypervisor migrates the one or more dirty memory pages.

Abstract: A playback page, which can include embedded media players and a user interface that functions as an Internet media station tuner, can be transmitted from a web server to a web browser running on a client computer. In response to receiving a message from the playback page indicating a user-selected media station, the web server transmits a message instructing the media station to transmit a tagged media stream to one media player (a Content Playback Instance), and transmits a browser file to an advertisement server. The browser file includes information used by the advertisement server to select targeted media content to be inserted into an untagged media stream delivered to another media player (an Ad Spot Playback Instance). The web server controls whether the Content Playback Instance presents a tagged media stream, or the Ad Spot Playback Instance presents targeted content, at any particular time.

Abstract: The present invention pertains to a cell culture medium comprising hypotaurine, GABA, and/or beta-alanine or the combination of choline and hypotaurine, GABA, and/or beta-alanine as media supplements which is shown to control viability, growth, and waste byproduct accumulation. The present invention further pertains to a method of producing a polypeptide of interest in a large scale cell culture containing hypotaurine, GABA, and/or beta-alanine or the combination of choline and hypotaurine, GABA, and/or beta-alanine.

Abstract: Playback of a tagged audio stream at mobile communications device, or other processing device, can be controlled transparently to a user of the device by implementing multiple instances of a media player. A Spot Caching Instance of the media player can receive and cache an untagged content stream from an advertisement server. A Content Playback Instance of the media player can be used to play back and process a tagged content stream from a radio station to identify tags. When the Content Playback Instance detects a tag, it transfers control to an Ad Spot Playback Instance of the media player, which can play back part or all of the untagged content stream from cache. When playback of the untagged content stream is completed, the Ad Spot Playback Instance transfers control back to the Content Playback Instance.

Abstract: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.

Abstract: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.

Abstract: Methods, systems, and computer program products are included for migrating a virtual machine. An example method of migrating a virtual machine includes providing a virtual machine by a source hypervisor. The source hypervisor initiates the running of a guest on the virtual machine. The source hypervisor sends the guest a migration indicator that corresponds to a migration of the virtual machine. The virtual machine is then placed in a suspended state. The source hypervisor receives a free memory page indicator from the guest that identifies one or more free memory pages. While the virtual machine is in the suspended state, the source hypervisor modifies a migration status of the identified one or more free memory pages to indicate that the identified one or more free memory pages are not to be migrated. After resuming operation of the virtual machine from the suspended state, the source hypervisor detects a dirty memory page indicator that identifies one or more dirty memory pages.