Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Abstract: There is provided inter alia a pharmaceutical dosage form for oral administration comprising a sanglifehrin as active ingredient in which the sanglifehrin active ingredient is protected from acid degradation in the stomach environment following oral administration.

Abstract: There is provided inter alia a compound of formula (I) or a pharmaceutically acceptable salt thereof and its use in therapy.

Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Abstract: A method of supporting a chain stopper on a vessel, a chain stopper assembly for a vessel, and a vessel. The method of supporting a chain stopper on a vessel may comprise the steps of connecting a swivel element to the support structure on the vessel such that the swivel element is pivotable around a first axis perpendicular to a substantially horizontal axis; and coupling a chain stopper element to the swivel element such that the chain stopper element is pivotable relative to the swivel element around the substantially horizontal axis.

Abstract: A roller assembly for a turret, a turret bearing system for a turret, and a method of manufacture of a roller assembly for a turret. The roller assembly comprises a first and a second roller; an axle on which the first and the second rollers are rotatably mounted; and a biasing mechanism located between the first and the second rollers and supporting the axle.

Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.

Abstract: An accelerator pedal assembly is disclosed. The accelerator pedal assembly can include a pedal configured to be movable by a vehicle operator to control a speed of a vehicle. In addition, the accelerator pedal assembly can include an electromagnetic resistance mechanism coupled to the pedal. The electromagnetic resistance mechanism can be configured to provide a force to resist movement of the pedal by the operator to indicate an operational condition of the vehicle to the operator.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: There are provided inter alia compounds of formula (I) useful as cyclophilin inhibitors.

Abstract: There is provided inter alia a compound of formula (I) or a pharmaceutically acceptable salt thereof and its use in therapy.

Abstract: There is provided inter alia a compound of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogs and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogs and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogs, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: A corrugated coupling may be provided. The corrugated coupling may be for coupling two cylindrical corrugated sections. The corrugated coupling may be a tubular element comprising a first portion and a second portion pivotably connected along a first edge, wherein the first edge comprises an integrated hinge. Each portion may have opposing second edges that come together in a closed configuration, forming the tubular element. Each second edge may provide a portion of an integrated snap closure that is positionable in a locked position sandwiching the joining two cylindrical corrugated sections between the first portion and the second portion and an unlocked position.

Abstract: The systems and methods of the invention modulate atmospheric gases to temporarily increase the amount of atmospheric particles in the path of the debris, in order to decelerate the debris and accelerate natural orbital decay to the point of atmospheric re-entry. In one aspect of the invention, clearing the space debris includes propelling a plume of atmospheric gases substantially orthogonal to the path of the debris such that the debris collides with the gaseous plume as it passes through the plume. Increased atmospheric drag from the gaseous particles of the plume in the path of the debris obstructs a forward propagation of the debris and gradually decelerates the debris, leading eventually to atmospheric recapture.

Abstract: There is provided inter alia a pharmaceutical dosage form for oral administration comprising a sanglifehrin as active ingredient in which the sanglifehrin active ingredient is protected from acid degradation in the stomach environment following oral administration.

Abstract: A roller assembly for a turret, a turret bearing system for a turret, and a method of manufacture of a roller assembly for a turret. The roller assembly comprises a first and a second roller; an axle on which the first and the second rollers are rotatably mounted; and a biasing mechanism located between the first and the second rollers and supporting the axle.

Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.