Abstract: The systems and methods of the invention modulate atmospheric gases to temporarily increase the amount of atmospheric particles in the path of the debris, in order to decelerate the debris and accelerate natural orbital decay to the point of atmospheric re-entry. In one aspect of the invention, clearing the space debris includes propelling a plume of atmospheric gases substantially orthogonal to the path of the debris such that the debris collides with the gaseous plume as it passes through the plume. Increased atmospheric drag from the gaseous particles of the plume in the path of the debris obstructs a forward propagation of the debris and gradually decelerates the debris, leading eventually to atmospheric recapture.

Abstract: There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: The systems and methods of the invention modulate atmospheric gases to temporarily increase the amount of atmospheric particles in the path of the debris, in order to decelerate the debris and accelerate natural orbital decay to the point of atmospheric re-entry. In one aspect of the invention, clearing the space debris includes propelling a plume of atmospheric gases substantially orthogonal to the path of the debris such that the debris collides with the gaseous plume as it passes through the plume. Increased atmospheric drag from the gaseous particles of the plume in the path of the debris obstructs a forward propagation of the debris and gradually decelerates the debris, leading eventually to atmospheric recapture.

Abstract: There are provided inter alia compounds of formula (I) useful as cyclophilin inhibitors.

Abstract: There is provided inter alia a compound of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: The systems and methods of the invention modulate atmospheric gases to temporarily increase the amount of atmospheric particles in the path of the debris, in order to decelerate the debris and accelerate natural orbital decay to the point of atmospheric re-entry. In one aspect of the invention, clearing the space debris includes propelling a plume of atmospheric gases substantially orthogonal to the path of the debris such that the debris collides with the gaseous plume as it passes through the plume. Increased atmospheric drag from the gaseous particles of the plume in the path of the debris obstructs a forward propagation of the debris and gradually decelerates the debris, leading eventually to atmospheric recapture.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

Abstract: The present invention relates to medical uses of 39-desmethoxyrapamycin analogues.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: A speaker assembly for a motorcycle which comprises a mounting portion adaptable to a motorcycle saddlebag and a mounting portion positioning a speaker to direct the speaker output towards the rider of the motorcycle.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: A foam-generating kit contains a non-aerosol container with a foam-generating dispenser and a high surfactant microemulsion or protomicroemulsion composition having at least 20 wt % of a surfactant system and 0.5 wt % glycerol.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their,preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: A riser system for use in transporting fluid cargo to a floating vessel from a submerged pipe employs a tensioning mechanism that prevents excess slack in a flexible riser that could potentially damage the riser. The tensioning mechanism includes a tensioning arm or element that is pivotally attached at a first end to a submerged base and at its second end to the flexible riser. The arm is free to rotate about the pivot point in a pendulum manner, but is urged toward an equilibrium position by one or more tension-applying elements disposed on the arm, such as a buoyancy element, a weight or both.

Abstract: The invention is a bearing unit and bearing system for supporting a large rotatable element, such as a mooring turret. The bearing unit includes a hydrostatic suspension system which enables the bearing unit to accommodate fabrication tolerances and also enables the bearing unit to conform to relative movements between the ship and the turret, thereby providing a compliant bearing system. The system includes multiple bearing units of the invention which serve as thrust and/or radial bearings for supporting the turret. By manifolding a plurality of bearing units together in a fluidly-isolated group, the pressure applied to the bearing units in that group is self-equalizing so that all the bearing units act in unison to equally support the load, while also allowing some degree of self-alignment and tilting of the load. As a result, the bearing system emulates a self-aligning bearing system and is able to compensate for axial and angular misalignment.

Abstract: A riser system for use in transporting fluid cargo to a floating vessel from a submerged pipe employs a tensioning mechanism that prevents excess slack in a flexible riser that could potentially damage the riser. The tensioning mechanism includes a tensioning arm or element that is pivotally attached at a first end to a submerged base and at its second end to the flexible riser. The arm is free to rotate about the pivot point in a pendulum manner, but is urged toward an equilibrium position by one or more tension-applying elements disposed on the arm, such as a buoyancy element, a weight or both.