Abstract: A vehicle is disclosed. The vehicle includes a passenger cabin; a steering assembly including a steering wheel mounted on a steering column assembly; and a ventilation system having a first air outlet for discharging a first jet of air, and a second air outlet for discharging a second jet of air. The first air outlet and the second air outlet are located on the steering column and the second jet of air intersects and deflects the first jet of air.

Abstract: Methods, systems, and computer-readable media are provided for blending data. The system may identify user behavior patterns such that relevant correlations are learned by the system and suggested to a user automatically. The system may also analyze each available data set to identify both present and potential correlations to suggest to a user. This provides an efficient means for the system to automatically narrow a compilation of data sets into a filtered group of suggested data sets for a user. Put another way, the system gathers data on user behavior and known correlations and uses various methodologies to generate new data sets to be automatically compared and catalogued.

Abstract: A wearable device. In some embodiments, the wearable device includes: a sensing module; and a strap attached to the sensing module, the wearable device being configured to be worn by a user, with a lower surface of the sensing module in contact with the user, the strap extending over an upper surface of the sensing module.

Abstract: Disclosed are PTHrP analogue formulations for transdermal delivery of a therapeutically effective amount of a PTHrP analogue, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

Abstract: A vehicle is disclosed. The vehicle includes a passenger cabin; a steering wheel having a hub and a rim; and a ventilation system having a first air outlet for discharging a first jet of air, and a second air outlet for discharging a second jet of air. The first jet of air projects through a gap between the hub and the rim, and the second jet of air intersects and deflects the first jet of air.

Abstract: A vehicle including a passenger cabin and a vent assembly is a disclosed. The vent assembly includes a duct for carrying an airflow and having an outlet through which the airflow is discharged into the passenger cabin; a deflector located within the duct, the deflector having a convex surface across which the airflow passes; and a valve extending around at least part of the convex surface for restricting the direction of the airflow across the convex surface. The airflow is discharged through the outlet in a direction defined by the direction of the airflow across the convex surface; and the valve is rotatable to vary the direction of the airflow across the convex surface.

Abstract: A vehicle is disclosed. The vehicle includes a passenger cabin; a steering assembly including a steering wheel mounted on a steering column assembly; and a ventilation system having a first air outlet for discharging a first jet of air, and a second air outlet for discharging a second jet of air. The first air outlet and the second air outlet are located on the steering column and the second jet of air intersects and deflects the first jet of air.

Abstract: A down-pressure system for an agricultural seeder includes single-action hydraulic cylinders connected between a rockshaft assembly and respective opener assemblies. The single-action hydraulic cylinders are connected to a pressure-regulated hydraulic circuit. The regulated pressure from the hydraulic circuit operates to bias the hydraulic cylinders in an extended direction to apply downforce to the opener assemblies when the rockshaft assembly is in its lowered condition with the opener assemblies engaging the soil. A double-acting hydraulic cylinder is provided for rotating the rockshaft assembly between a raised transport position and a lowered field working position. The double-acting hydraulic cylinder and the single-action hydraulic cylinders for applying down-pressure to the opener assemblies can be operated on the same hydraulic circuit, or on separate circuits.

Abstract: Provided herein are methods for treating osteoporosis and increasing bone mass density, that includes administering once a day, for about 5 minutes, a transdermal patch loaded with about 300 ?g of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide. Also provided are the single-use transdermal patches loaded with about 300 ?g of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide.

Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

Abstract: A medical device comprising a composition comprising a therapeutically active amount of active agent, a zinc compound, and an array of microneedles. The zinc compound may be selected from the group consisting of zinc, pharmaceutically acceptable salts of zinc, and mixtures thereof. At least a portion of the composition is present as a coating on at least a portion of the microneedles. Methods of delivering a therapeutically active agent to a mammal using compositions of the disclosure are also included.

Abstract: A trocar assembly includes a cannula having a proximal portion and an opposing distal portion. The distal portion is configured to extend into a patient body. The cannula defines an access channel between the proximal portion and the distal portion, wherein the access channel is configured to receive a scope such that the scope can be maneuvered through the access channel to a location within the patient body. A cleaning element at the distal portion is configured to contact at least a distal end of the scope.

Abstract: A trocar assembly with an integrated scope-cleaning structure may have a proximal portion configured for accessibility by a user and a cannula extending distally from the proximal portion and configured to extend distally into a patient body, where the cannula is further configured to receive a distal end of a scope such that the scope can be maneuvered through the cannula to a location within the patient body. A cleaning element may be included, where the proximal portion includes a housing, where the cleaning element is substantially located within the housing.

Abstract: A medical device comprising a composition comprising a therapeutically active amount of active agent, a zinc compound, and an array of microneedles. The zinc compound may be selected from the group consisting of zinc, pharmaceutically acceptable salts of zinc, and mixtures thereof. At least a portion of the composition is present as a coating on at least a portion of the microneedles. Methods of delivering a therapeutically active agent to a mammal using compositions of the disclosure are also included.

Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

Abstract: The present disclosure relates to a trocar assembly with an integrated scope-cleaning structure. The trocar assembly may include a housing defining boundaries of a chamber with (a) a proximal opening configured to receive a distal end of a scope, and (b) a distal opening in fluid and mechanical communication with a trocar cannula. The trocar assembly may further include a cleaning element located at least partially between the proximal opening and the distal opening, where the cleaning element is movable with respect to the housing from at least a first setting where a first portion of the cleaning element may be in a first location and may form a first cleaning surface within the chamber, the first cleaning surface configured to remove debris from a distal end of the scope when the distal end of the scope contacts the first portion of the cleaning element.