Patents by Inventor Albert A. Carr

Albert A. Carr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates useful for the preparation of antihistaminic piperidine derivatives
    Patent number: 6242606
    Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.
    Type: Grant
    Filed: July 14, 1994
    Date of Patent: June 5, 2001
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
  • Novel intermediates useful for the preparation of antihistaminic piperidine derivatives
    Publication number: 20010000038
    Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula 1
    Type: Application
    Filed: December 1, 2000
    Publication date: March 15, 2001
    Inventors: Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
  • Intermediates useful for the preparation of antihistaminic piperidine derivatives
    Patent number: 6147216
    Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--;R.sub.1 represents hydrogen or hydroxy;R.sub.2 represents hydrogen;R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;n is an integer of from 1 to 5;m is an integer 0 or 1;R.sub.3 is --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof,with the proviso that where R.sub.1 and R.sub.2 are ta to form a second bond between the carbon R.sub.1 and R.sub.2 or where R.sub.1 represented hydroxy integer 0.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 14, 2000
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
  • Esters of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidi nemethanol
    Patent number: 6063793
    Abstract: The present invention is directed to esters of (+)-.alpha.-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: May 16, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Albert A. Carr, Raymond W. Kosley, Jr., Luc Van Hijfte
  • Esters of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
    Patent number: 6028083
    Abstract: The present invention is directed to esters of (+)-.alpha.-(2,3 Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: February 22, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Albert A. Carr, Raymond W. Kosley, Jr., Luc Van Hijfte
  • (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2- (4-fluorophenyl)ethyl]-4-piperidinemethanol
    Patent number: 6004980
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: December 21, 1999
    Assignee: Merrell Pharmaceuticals, Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • Cyclic nitrones
    Patent number: 5962469
    Abstract: The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 5, 1999
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Craig E. Thomas, Thomas L. Fevig, Stephen M. Bowen, Robert A. Farr, Albert A. Carr, David A. Janowick
  • (+) -.alpha.- (2,3-dimethoxyphenyl)-1-(2-(4-fluorephenyl) ethyl)-4-piepridinemethanol
    Patent number: 5874445
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: February 23, 1999
    Assignee: Merrell Pharmaceutical, Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • Piperidinyl thiacyclic derivatives
    Patent number: 5739150
    Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 14, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
  • (+)-.alpha.-(2,3-di methoxyphenyl)-1-?2-(4-flurophenyl)etyl!-4-piperidinemethanol
    Patent number: 5721249
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluor ophenyl)ethyl!-4-piperidinemethanol
    Patent number: 5700813
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-pip eridinemethanol
    Patent number: 5700812
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • Cyclic nitrones
    Patent number: 5677315
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 14, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas
  • Piperidinyl thiacyclic derivatives
    Patent number: 5650416
    Abstract: Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 22, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
  • Piperidinyl thiacyclic derivatives
    Patent number: 5631268
    Abstract: Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: May 20, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
  • Piperidinyl thiacyclic derivatives
    Patent number: 5602147
    Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: February 11, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
  • Piperidinyl thiacyclic derivatives
    Patent number: 5596003
    Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 21, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
  • (+)-.alpha.-(2,3-dime thoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
    Patent number: 5561144
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: October 1, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide derivatives
    Patent number: 5541201
    Abstract: The invention is directed to a new class of antiarrhythmic agents of the formula: ##STR1## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, NHC(O)R.sub.2, NH.sub.2, or OH; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is C.sub.1-4 alkyl; X is represented by CO or CHOH; R.sub.3 and R.sub.4 are each independently represented by methyl, ethyl, n-propyl, or R.sub.3 and R.sub.4 together with the carbon atom to which they each are attached form a C.sub.5 or C.sub.6 cycloalkyl; and Alk is a C.sub.1-4 alkyl; or a pharmaceutically acceptable addition salt thereof.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 30, 1996
    Assignee: Merrell Pharmaceuticals, Inc.
    Inventors: Albert A. Carr, Richard C. Dage, David A. Hay, John E. Koerner, Tung Li
  • Piperidinyl thiacyclic derivatives
    Patent number: 5541200
    Abstract: Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 30, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley