Patents by Inventor Albert A. Carr

Albert A. Carr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic nitrones
    Patent number: 5532252
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 2, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Cyclic nitrones
    Patent number: 5527812
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 18, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Cyclic nitrones
    Patent number: 5525615
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 11, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Ronald C. Bernotas, Craig E. Thomas
  • Method of treating drug abuse
    Patent number: 5500433
    Abstract: The present invention is directed to a new class of piperidinyl medicinal agents which are useful for treating drug abuse.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: March 19, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller, Thaddeus R. Nieduzak, Mark W. Dudley, . Christopher J. Schmidt, Robert A. Frank
  • Cyclic nitrone compounds useful in treating stroke
    Patent number: 5498778
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: March 12, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • 1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia
    Patent number: 5478846
    Abstract: The present invention is direct to a new class of 1-piperidinyl alkanoarylsulfonamides of the formula I ##STR1## wherein R, X, m, n, and Alk are defined in the specification, and their use as antiarrhythmic agents.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: December 26, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, Thaddeus R. Nieduzak, John E. Koerner, Tung Li
  • Piperidinyl thiacyclic derivatives
    Patent number: 5476861
    Abstract: Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: December 19, 1995
    Assignee: Merrell Dow Pharmaceuricals Inc.
    Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
  • Cyclic nitrones
    Patent number: 5397789
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: March 14, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Antiallergic compounds
    Patent number: 5380731
    Abstract: The present invention is directed to a new class of piperidinyl benzimidazoles that are useful in the treatment of allergic disorders.
    Type: Grant
    Filed: August 17, 1993
    Date of Patent: January 10, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, Hsien C. Cheng
  • Piperidinyl thiacyclic derivatives
    Patent number: 5371093
    Abstract: Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: December 6, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, George D. Maynard, John M. Kane, Hsien C. Cheng, Mark W. Dudley
  • Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
    Patent number: 5292746
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Antithrombotic compounds
    Patent number: 5292752
    Abstract: The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller, Thaddeus R. Nieduzak
  • Piperidinyl compounds
    Patent number: 5286866
    Abstract: The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: February 15, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John E. Koerner, Richard C. Dage, Tung Li
  • N-aralkyl-piperidine-methanol derivatives
    Patent number: 5169096
    Abstract: This invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5HT.sub.2 receptor site, and to the processes for their preparation and use.
    Type: Grant
    Filed: January 3, 1991
    Date of Patent: December 8, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Norbert L. Wiech
  • Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina
    Patent number: 5166211
    Abstract: The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: November 24, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller
  • Use of 1,4-disubstituted-piperidinyl compounds for analgesia and muscle relaxation
    Patent number: 5162342
    Abstract: The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: November 10, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Francis P. Miller, Thaddeus R. Nieduzak, Stephen M. Sorensen
  • (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[ 2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
    Patent number: 5134149
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: July 26, 1991
    Date of Patent: July 28, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • Calcium antagonists
    Patent number: 5106845
    Abstract: The present invention is directed to a new class of cyclic guanidines of the formula: ##STR1## in which Q is represented by a substituent selected from the group consisting of (CH.sub.2).sub.n in which n is an integer from 2-10, ##STR2## A is a substituent selected from the group consisting of --NH--(CH.sub.2).sub.m in which m is an integer from 0-5, a piperidino substituent, or a piperazino substituent; both Ar and Ar.sub.1 are each independently represented by a phenyl ring, each of which may be optionally substituted with up to 3 substituents, each selected from the group consisting of halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, and trifluoromethyl; and R is represented by either hydrogen or a C.sub.1-4 alkyl; R.sub.1 is represented by hydrogen or a C.sub.1-4 alkyl; the optional isomers and tautomers thereof; and the pharmaceutically acceptable acid addition salts thereof, and their use as calcium antagonists.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: April 21, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Hsien C. Cheng, John M. Kane
  • N-aralkyl piperidine derivatives useful as antithrombolytic agents
    Patent number: 5093341
    Abstract: The present invention is directed to a new class of compounds useful as antiarrhythmics, analgesics and serotonin 5HT.sub.2 antagonists, which compounds have the following formula: ##STR1## wherein; Y is represented by H, CO(CH.sub.2).sub.n CH.sub.3 in which n is an integer from 0-3, or SO.sub.2 (CH.sub.2).sub.n CH.sub.3 in which n is an integer from 0--3; X is represented CO, CHOH, or C.dbd.N--O--A, wherein A is represented by hydrogen or a C.sub.1-4 alkyl; R is either selected from the group consisting of halogens, lower alkyl groups, lower alkoxy groups, and hydrogen or R is a divalent substituent and is represented by a 3,4-methylenedioxy or a 3,4-ethylenedioxy substituent; m is an integer from 1-5; and the pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: March 3, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John E. Koerner, Richard C. Dage, Tung Li, Francis P. Miller
  • Anti-psychotic piperidylbenzimidazole compounds
    Patent number: 5064840
    Abstract: The present invention is directed to a new class of therapeutic agent which are useful as anti-psychotic agents and as analgesics.
    Type: Grant
    Filed: April 10, 1990
    Date of Patent: November 12, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Albert A. Carr, Francis P. Miller, John M. Kane