Abstract: Antagonists of interleukin 11 (IL-11)-mediated signalling are disclosed. Also disclosed are pharmaceutical compositions, antibodies, antigen binding fragments, antisense oligonucleotides, siRNA molecules, pharmaceutical combinations, and medical uses in methods of treating a disease or condition characterised by glomerular dysfunction.

Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: Computer systems and associated methods are disclosed to implement the non-interactive join of privacy-preserving dataset sketches. In some embodiments, an entity can publish a one-time sketch of their dataset that would enable another entity to join their data without exposing private information. The sketch can map, using a hash function, the identities associated with a first value of the dataset to a data structure, in some embodiments. A same or different entity can join the first sketch with a privacy-preserving second sketch of a second dataset that includes added noise, and can determine an estimate of a number of identities that correspond with specific values of the first and second datasets from the joined dataset. The sketch can be published just one time, and therefore does not require separate new private computations with privacy budgeting for each additional party when a join is desired, in some embodiments.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.

Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition or IL-11-mediated signalling.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Computer systems and associated methods are disclosed to implement the non-interactive join of privacy-preserving dataset sketches. In some embodiments, an entity can publish a one-time sketch of their dataset that would enable another entity to join their data without exposing private information. The sketch can map, using a hash function, the identities associated with a first value of the dataset to a data structure, in some embodiments. A same or different entity can join the first sketch with a privacy-preserving second sketch of a second dataset that includes added noise, and can determine an estimate of a number of identities that correspond with specific values of the first and second datasets from the joined dataset. The sketch can be published just one time, and therefore does not require separate new private computations with privacy budgeting for each additional party when a join is desired, in some embodiments.

Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition of IL-11-mediated signalling.

Abstract: A footrest safety pad arrangement is incorporated in a stairlift carriage in which movement of a safety pad relative to the carriage is sensed by an electromagnetic sensor and a control signal applied to the stairlift drive motor.

Abstract: Methods of treating and preventing Alport syndrome through inhibiting interleukin 11 (EL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A method is provided for ensuring the integrity of a stairlift installation constructed from re-used components. Data representative of the form of a stairlift rail is stored in a control facility included in the stairlift carriage and then compared with data sensed in real time. A stairlift carriage may be disabled in the event sensed data varies from stored data.

Abstract: The disclosure defined by this invention relates to an electronic control facility for a stairlift. The control facility includes an installation mode in which a number of steps to be undertaken at the time of installation of the stairlift are defined. The control facility also includes a user mode in which the operation of the stairlift is controlled by a user. According to the invention, the control facility is configured so that the user mode cannot be entered until all steps in the installation mode have been completed.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A method, computer program product, and computing device for monitoring network activity associated with streaming a data load through a stream application including a plurality of stream operators deployed on a plurality of computing devices. One or more stream operators with one or more external connections may be identified from the plurality of stream operators. The identified one or more stream operators may be deployed based upon, at least in part, the one or more external connections.

Abstract: Queries are monitored in a database which receives input from a stream computing application to identify data of interest. Parameters defining the data of interest, which are preferably expressed as a logical query, are sent to the stream computing application, which then processes the in-flight streamed data satisfying the parameters in some special manner. In some embodiments, the stream computing application increases the processing priority of in-flight data satisfying the parameters. In some embodiments, the stream computing application applies additional processing steps to the in-flight data satisfying the parameters to provide enhanced data or metadata.