Abstract: Provided are antigen-binding molecules capable of binding to IL-11R?, and methods of medical treatment and prophylaxis using the same.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.

Abstract: Methods for the diagnosis, treatment and prophylaxis of fibrosis and/or angiogenesis, in particular in the eye, are disclosed. In particular embodiments, the methods employ antagonism of IL-11 mediated signalling and antagonism of angiogenesis. Also provided are combinations comprising an antagonist of IL-11 mediated signalling and an antagonist of an angiogenic factor.

Abstract: IL-11 antibodies are disclosed. Also disclosed are compositions comprising the IL-11 antibodies, and methods using the IL-11 antibodies.

Abstract: IL-11R? antibodies are disclosed. Also disclosed are compositions comprising the IL-11R? antibodies, and methods using the IL-11R? antibodies.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.

Abstract: A topology for an isolated, bi-directional, DC-DC converter, that provides step-up and step-down functionality, with a reduced transformer turns ratio, allows a simplified transformer design with reduced cost and increased efficiency. This topology also has a very small level of re-circulating current, relative to other topologies regarding cost and performance.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: System resource usage by a streaming application processing workloads can be monitored, the streaming application comprising at least one parallelizable operator, at least a first instance of the parallelizable operator being initialized to execute. Based on the monitoring, at least one performance metric for the streaming application in processing the workloads can be determined. Based on the at least one performance metric, whether hosting of the streaming application is, or is near to, violating at least one criteria can be determined. If so, at least one additional instance of at least one parallelizable operator of the streaming application that is currently executing can be initialized. Responsive to initializing the at least one additional instance of at least one of the parallelizable operators, a portion of the workloads can be directed to the at least one additional instance of at least one of the parallelizable operators.

Abstract: Disclosed aspects relate to cache management in a stream computing environment that uses a set of many-core hardware processors to process a stream of tuples by a plurality of processing elements which operate on the set of many-core hardware processors. The stream of tuples to be processed by the plurality of processing elements which operate on the set of many-core hardware processors may be received. A tuple-processing hardware-route on the set of many-core hardware processors may be determined based on a cache factor associated with the set of many-core hardware processors. The stream of tuples may be routed based on the tuple-processing hardware-route on the set of many-core hardware processors. The stream of tuples may be processed by the plurality of processing elements which operate on the set of many-core hardware processors.

Abstract: Aspects of the disclosure relate to using a set of warning data to manage distributed development of an application in a computing environment. In embodiments, the computing environment may include a distributed computing environment or a stream computing environment. A first portion of the application may be developed by a first user. A second portion of the application may be received by the first user. The second portion of the application may be compiled and developed by a second user. Based on the set of warning data, a curative action for utilization to develop the application may be formulated. The curative action may be carried-out to develop the application.

Abstract: A method, computer program product, and computer system for consolidating, at a computing device, a number of parallel streams, entering a hardware accelerator in a cluster, into fewer streams. The fewer streams, exiting the hardware accelerator in the cluster, may be returned back into the number of parallel streams.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: A database which receives input from a data streaming application may include in-flight streamed data within the scope of a command which alters database data. Preferably, the streaming application produces data tuples for input to at least one table of the database. A user submitting modify data commands to apply to multiple tuples meeting some specified logical parameters may define the command scope to include in-flight data in the streaming application, causing the database manager to forward the command to the streaming application. A streaming application manager invokes database agents in respective nodes of the streaming application, which identify in-flight data meeting the specified logical parameters of the command, and apply the modify data operation to such data.