Abstract: The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity.

Abstract: A process for the production of an aromatic carboxylic acid comprising contacting in the presence of a catalyst, within a continuous flow reactor, one or more precursors of the aromatic carboxylic acid with an oxidant, such contact being effected with said precursor(s) and the oxidant in an aqueous solvent comprising water under supercritical conditions or near supercritical conditions close to the supercritical point such that said one or more precursors, oxidant and aqueous solvent constitute a substantially single homogeneous phase in the reaction zone, wherein the contact of at least part of said precursor with said oxidant is contemporaneous with contact of said catalyst with at least part of said oxidant.

Abstract: The present invention combines the use of template switching with nucleic acid amplification—such as PCR—to generate amplification products representative of an entire RNA population. An RNA polymerase promoter sequence allows transcription-based amplification to be performed on the derived amplification products such that antisense amplified RNA (aRNA) or complementary RNA (cRNA) is produced for subsequent downstream applications.

Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.

Abstract: This invention features ring-substituted pyrrolo-?-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas I–III, which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.

Abstract: The IKOS holistic game of this invention comprises a semi-regular geometric solid of 32 faces. 12 faces are regular pentagons interfaced to 20 equilateral triangles. The polyhedron also comprises 60 equal upstand edges each one of which subtends 36 degrees at the centroid of the polyhedron. It also comprises 30 equal vertices at which four edges and four faces meet. The surface elements 1 of the IKOS are of seven distinct colors, with each surface element being of one color only. There are six sets of like colored surface elements with two pentagons and ten up-stands in each set. All the triangular panels are in the seventh, neutral, shade. Also included is a method of designing the 32'dron on a CAD system.

Abstract: An engine cooling module 10 which includes a shroud 12, a heat exchanger 18, a fan 14, a motor 13 for driving fan 14, and a plurality of air dams 1. Shroud 12, circumscribing the fan, has a main opening to allow air to pass through the fan to or from a heat exchanger 18. Fan 14 is associated with the shroud 12 to be adjacent to the fan opening to permit air moved by the fan to pass through the heat exchanger. Air dams 1 allow air to flow more easily in one direction than the opposite direction. In the fan flow direction, air dams 1 provide relatively little resistance to the flow. In the direction opposite to fan flow direction, air dams 1 provide more resistance than as compared to the resistance when air flows in the fan flow direction. Under ram air conditions (e.g., when the vehicle is moving), the use of air dams can reduce the load on the fan's motor by cooling properties of ram air, while reducing recirculation, thereby increasing efficiency.

Abstract: This invention features ring-substituted pyrrolo-&bgr;-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas I-III, which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.

Abstract: The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicament, a method of therapeutic treatment using such a compound and processes for producing the compounds.

Abstract: The invention provides a method for measuring an acyl coenzyme A (acyl CoA) ester or esters in a sample, comprising the steps of: a) forming a reaction mixture comprising the sample to be tested and a derivatizing agent; b) allowing the sample and said derivatizing agent to react, so as to form a fluorescent derivative(s) of any acyl CoA ester(s) present in the sample; and c) determining a level of said fluorescent derivative(s).

Abstract: A process for the production of an aromatic carboxylic acid comprising contacting in the presence of a catalyst, within a continuous flow reactor, one or more precursors of the aromatic carboxylic acid with an oxidant, such contact being effected with said precursor(s) and the oxidant in an aqueous solvent comprising water under supercritical conditions or near supercritical conditions close to the supercritical point such that said one or more precursors, oxidant and aqueous solvent constitute a substantially single homogeneous phase in the reaction zone, wherein the contact of at least part of said precursor with said oxidant is contemporaneous with contact of said catalyst with at least part of said oxidant.

Abstract: The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicament, a method of therapeutic treatment using such a compound and processes for producing the compounds.

Abstract: A process for the production of an aromatic carboxylic acid comprising contacting in the presence of a catalyst, within a continuous flow reactor, one or more precursors of the aromatic carboxylic acid with an oxidant, such contact being effected with said precursor(s) and the oxidant in an aqueous solvent comprising water under supercritical conditions or near supercritical conditions close to the supercritical point such that said one or more precursors, oxidant and aqueous solvent constitute a substantially single homogeneous phase in the reaction zone, wherein the contact of at least part of said precursor with said oxidant is contemporaneous with contact of said catalyst with at least part of said oxidant.

Abstract: The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicament, a method of therapeutic treatment using such a compound and processes for producing the compounds.

Abstract: The IKOS holistic game of this invention comprises a semi-regular geometric solid of 32 faces. 12 faces are regular pentagons interfaced to 20 equilateral triangles. The polyhedron also comprises 60 equal upstand edges each one of which subtends 36 degrees at the centroid of the polyhedron. It also comprises 30 equal vertices at which four edges and four faces meet. The surface elements 1 of the IKOS are of seven distinct colors, with each surface element being of one color only. There are six sets of like colored surface elements with two pentagons and ten up-stands in each set. All the triangular panels are in the seventh, neutral, shade.

Abstract: An engine cooling module 10 which includes a shroud 12, a heat exchanger 18, a fan 14, a motor 13 for driving fan 14, and a plurality of air dams 1. Shroud 12, circumscribing the fan, has a main opening to allow air to pass through the fan to or from a heat exchanger 18. Fan 14 is associated with the shroud 12 to be adjacent to the fan opening to permit air moved by the fan to pass through the heat exchanger. Air dams 1 allow air to flow more easily in one direction than the opposite direction. In the fan flow direction, air dams 1 provide relatively little resistance to the flow. In the direction opposite to fan flow direction, air dams 1 provide more resistance than as compared to the resistance when air flows in the fan flow direction. Under ram air conditions (e.g., when the vehicle is moving), the use of air dams can reduce the load on the fan's motor by cooling properties of ram air, while reducing recirculation, thereby increasing efficiency.

Abstract: A fan shroud structure 10 including a shroud body 12 having a pair of opposing first sides 14 and a pair opposing second sides 16. The first sides 14 are joined with the second sides 16 at corners 18 so as to form a box-like configuration defining an interior space 20. The shroud body has a front end constructed and arranged to be disposed adjacent to a condenser and a back end constructed and arranged to be disposed adjacent to a radiator. Generally annular wall structure 26 is within the interior space and is constructed and arranged to receive blades of a fan within bounds thereof. Vortex preventing structure 40 is provided in each corner near the back end. The vortex preventing structure is constructed and arranged to prevent large scale eddy current generation of air in the corners as air enters the radiator. Air deflecting structure 50 is provided in each corner near the front end.

Abstract: A turbomachine for moving air comprising includes a shroud disposed about a longitudinal axis and a rotor assembly mounted for rotation about the longitudinal axis. The rotor assembly has a plurality of blades and tips of the blades are coupled to an annular band. The annular band is disposed with respect to the shroud so as to define a gap extending continuously between an outer surface of the annular band and an inner surface of the shroud. A seal structure extends from the inner surface of the shroud and into the gap. The seal structure has a density sufficient to reduce swirl in recirculating airflow and to minimize air leakage across the gap.

Abstract: A fan shroud structure 10 including a shroud body 12 having a pair of opposing first sides 14 and a pair opposing second sides 16. The first sides 14 are joined with the second sides 16 at corners 18 so as to form a box-like configuration defining an interior space 20. The shroud body has a front end constructed and arranged to be disposed adjacent to a condenser and a back end constructed and arranged to be disposed adjacent to a radiator. Generally annular wall structure 26 is within the interior space and is constructed and arranged to receive blades of a fan within bounds thereof. Vortex preventing structure 40 is provided in each corner near the back end. The vortex preventing structure is constructed and arranged to prevent large scale eddy current generation of air in the corners as air enters the radiator. Air deflecting structure 50 is provided in each corner near the front end.

Abstract: A process for the production of an exothermically reacting composition, such as a propellant or explosive, containing at least one normally solid reactive constituent comprises the steps of: forming a uniform dispersion of the ingredients of the said composition in a carrier liquid; forming droplets of said dispersion; feeding said droplets into a cooling medium at a temperature below the freezing point of said carrier liquid to form solidified droplets; and freeze-drying said solidifed droplets.