Abstract: An implant for stabilizing spinous processes of adjacent vertebral bodies can include first and second contact elements. The first contact element is placed onto a first side of the spinous processes and the second contact element is placed onto a second side of the spinous processes. The implant includes at least one clamping element which couples to the first contact element, can be moved relative to the second contact element, and extends through the intervertebral space between the spinous processes and the second contact element. The implant also includes at least one fixing element on the second contact element which can be brought into engagement with the at least one clamping element to clamp the second contact element in the direction of the first contact element along the at least one clamping element. The first contact element is movable relative to the at least one clamping element.

Abstract: An electric drive motor for a work apparatus includes a stator having two stator poles which are at a distance from one another in the circumferential direction and have respective field windings. The motor has a rotor which rotates between the stator poles and the rotor shaft of the rotor drives a fan wheel. The cooling-air flow generated by the fan wheel enters the stator, flows therethrough and is discharged therefrom. For effective cooling, a pole intermediate space is provided between the stator poles; and, for the cooling-air flow, this space is filled by a non-magnetic guide body to provide a cooling duct delimited by the guide body and the field windings. The guide body is fastened to a support at one stator end and is inserted axially into the stator at the other end thereof.

Abstract: Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.

Abstract: The present invention relates to the identification and functional characterization of human cell-penetrating peptides (CPPs) and their use; in particular as transfection vehicles.

Abstract: An implant for supporting the spinous processes of adjacent vertebral bodies includes a first implant component and a second implant component and is transferable by moving the second implant component relative to the first implant component along a spreading direction from an introduction position into a spread position. The implant includes a locking device incorporating a locking element wherein the locking element is transferable relative to at least one implant component along a locking direction from a release position, in which the second implant component is movable relative to the first implant component in a direction opposed to the spreading direction, into a locking position in which the second implant component is locked to the first implant component. The implant also includes a securing device for securing the locking element against a movement that is directed counter to the locking direction.

Abstract: The present invention relates to bivalent, multispecific antibodies, especially bivalent, trispecific antibodies which bind to human HER1, human HER2, and human HER3, their manufacture and use.

Abstract: This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: A surgical apparatus includes an implant for mutually supporting an upper spinous process of a first vertebral body and a lower spinous process of a second vertebral body. The implant comprises a first implant component and a second implant component movable relative thereto along a clamping direction to transfer the implant out of a basic position in a spreading direction that is oriented transversely relative to the clamping direction into a spread position. The implant includes at least one introduction-side upper supporting element and at least one introduction-side lower supporting element that for laterally supporting the upper spinous process or the lower spinous process on the introduction-side. A fixing device for the implant is used for spreading the at least one introduction-side upper supporting element and the at least one introduction-side lower supporting element relative to each other along the spreading direction in an introduction position of the implant.

Abstract: An implant for stabilizing spinous processes of adjacent vertebral bodies can include first and second contact elements. The first contact element is placed onto a first side of the spinous processes and the second contact element is placed onto a second side of the spinous processes. The implant includes at least one clamping element which couples to the first contact element, can be moved relative to the second contact element, and extends through the intervertebral space between the spinous processes and the second contact element. The implant also includes at least one fixing element on the second contact element which can be brought into engagement with the at least one clamping element to clamp the second contact element in the direction of the first contact element along the at least one clamping element. The first contact element is movable relative to the at least one clamping element.

Abstract: The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: In a surgical severing instrument comprising two cutting jaws movable relative to each other from an open position to a cutting position by means of hand grips movable relative to each other, in order to improve the handling, in particular, of the severed parts, it is proposed that two clamping jaws movable relative to each other from an initial position to a clamping position be arranged alongside the cutting jaws, and that actuators be provided on the surgical severing instrument, which, upon movement of the cutting jaws from the open position to the cutting position, simultaneously move the clamping jaws from their initial position to the clamping position.

Abstract: An electric drive motor for a work apparatus includes a stator having two stator poles which are at a distance from one another in the circumferential direction and have respective field windings. The motor has a rotor which rotates between the stator poles and the rotor shaft of the rotor drives a fan wheel. The cooling-air flow generated by the fan wheel enters the stator, flows therethrough and is discharged therefrom. For effective cooling, a pole intermediate space is provided between the stator poles; and, for the cooling-air flow, this space is filled by a non-magnetic guide body to provide a cooling duct delimited by the guide body and the field windings. The guide body is fastened to a support at one stator end and is inserted axially into the stator at the other end thereof.

Abstract: The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: Instruments and methods for inserting a spinal fixation rod include various components for inserting a rod with visual guidance. One kit includes a plurality of hollow elongated extension tubes and rod templates. The tube connectors connect the extension tubes in series. Another kit includes a rod guidance instrument having a sleeve. A guide member is attachable to the midsection of the sleeve, and a spinal fixation rod is attachable to the distal end of the sleeve. A method for inserting a spinal fixation rod into a plurality of rod receiving implants includes the steps of contouring a fixation rod to conform to a predetermined shape, contouring a guide member to match the shape of the contoured rod, and guiding the fixation rod into a rod receiving implant by maneuvering the guide member through a guide slot representing the location of the rod receiving implant.

Abstract: In order to improve a bone screw with a shaft defining a longitudinal axis and with a head which can be brought into engagement with a bone screw receiving means of a bone plate for the releasable connection of the bone screw to the bone plate, wherein a securing element for securing a connection between the bone screw and the bone plate is provided, wherein the bone screw can be brought from a position of engagement, in which the bone screw is held on the bone plate, into a release position, in which the bone screw can be released from the bone plate, wherein the securing element can be brought from a non-securing position, in which the bone screw can be brought into the release position, into a securing position for securing the connection between the bone screw and the bone plate, in which the bone screw takes up the position of engagement, such that a bone plate can be fixed to bone parts more easily and more securely it is suggested that the securing element be supported on the bone screw so as to be mov

Abstract: A surgical apparatus includes an implant for mutually supporting an upper spinous process of a first vertebral body and a lower spinous process of a second vertebral body. The implant comprises a first implant component and a second implant component movable relative thereto along a clamping direction to transfer the implant out of a basic position in a spreading direction that is oriented transversely relative to the clamping direction into a spread position. The implant includes at least one introduction-side upper supporting element and at least one introduction-side lower supporting element that for laterally supporting the upper spinous process or the lower spinous process on the introduction-side. A fixing device for the implant is used for spreading the at least one introduction-side upper supporting element and the at least one introduction-side lower supporting element relative to each other along the spreading direction in an introduction position of the implant.

Abstract: An implant for supporting the spinous processes of adjacent vertebral bodies includes a first implant component and a second implant component and is transferable by moving the second implant component relative to the first implant component along a spreading direction from an introduction position into a spread position. The implant includes a locking device incorporating a locking element wherein the locking element is transferable relative to at least one implant component along a locking direction from a release position, in which the second implant component is movable relative to the first implant component in a direction opposed to the spreading direction, into a locking position in which the second implant component is locked to the first implant component. The implant also includes a securing device for securing the locking element against a movement that is directed counter to the locking direction.

Abstract: This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof.

Abstract: The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: An intervertebral disk prosthesis system, which is used for forming an artificial intervertebral disk and comprises a first and a second prosthesis component wherein each of the two prosthesis components comprises a first and a second vertebral body contacting element for placement on neighboring vertebral bodies bounding an intervertebral disk space of a spinal column and a joint element that is mounted between and is moveable relative to at least one of the first and second vertebral body contacting elements, attains a substantially natural range of motion independent of the positioning of the two prosthesis components relative to each other and to the neighboring vertebral bodies. Each prosthesis component has a ball joint formed between the first and second vertebral body contacting elements.