Abstract: An intravascular lithotripsy catheter can include a sheath, first and second insulated wires, and a carrier. The first and second insulated wires can include exposed portions of an electrically conductive member and can be wound around the sheath. Exposed portions of the first and second insulated wires that form an emitter can be circumferentially offset from each other and can be longitudinally offset from each other. The carrier can encase the first and second insulated wires and the sheath and can comprise a plurality of carrier openings aligned with the exposed portions of the first and second insulated wires. The catheter can electrically connect to an energy generator that is operable to cause a spark to travel longitudinally along the catheter and circumferentially around the catheter between the exposed portions.

Abstract: An intravascular lithotripsy system can include a sheath configured to receive a guidewire, at least three insulated wires, and an energy generator. Each of the at least three insulated wires can comprise at least two exposed portions spaced from one another along a length of the insulated wire. The at least three insulated wires can be helically wound around the sheath and independently electrically connected with an energy generator. The exposed portions of the at least three insulated wires can define a plurality of emitters spaced from one another along a length of the sheath and which are independently operable by the energy generator. The energy generator can induce a spark via each of the plurality of emitters.

Abstract: An endoscopic device has a handle including an adapter, a shaft connected to the handle, and one or more wires within the handle. The adapter defines one or more openings in a side or proximal end of the adapter. The shaft has a plurality of lumens extending from a proximal end of the shaft to a distal end of the shaft. A first lumen of the plurality of lumens is a working channel for receiving a medical instrument. Each of the one or more wires enter through the one or more openings in the adapter for guiding the one or more wires to a corresponding lumen other than the first lumen and to the distal end of the shaft.

Abstract: The present disclosure relates to drug delivery devices, and in particular, to drug delivery devices configured to reconstitute a lyophilized drug powder into liquid form prior to delivery into a patients body. In some embodiments, such devices include a flexible drug reservoir having a proximal reservoir component storing a liquid diluent and a distal reservoir component storing a lyophilized drug powder, wherein the two compartments are separated by a frangible seal. A compression member may be positioned above the reservoir and held up by a releasable mechanism. When released, the compression member may be driven downwards to compress the proximal compartment so as to break the frangible seal and allow the diluent to mix with the drug powder and form a liquid drug mixture, and then to eject the liquid drug mixture from the reservoir.

Abstract: Disclosed herein are systems, devices, and processes for gesture detection. A method includes capturing a series of images. The method includes generating motion isolation information based on the series of images. The method includes generating a composite image based on the motion isolation information. The method includes determining a gesture based on the composite image. The processes described herein may include the use of convolutional neural networks on a series of time-related images to perform gesture detection on embedded systems or devices.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to fingerprint an audio signal via exponential normalization. An example apparatus includes an audio segmenter to divide an audio signal into a plurality of audio segments including a first audio segment and a second audio segment, the first audio segment including a first time-frequency bin, the second audio segment including a second time-frequency bin, a mean calculator to determine a first exponential mean value associated with the first time frequency bin based on a first magnitude of the audio signal associated with the first time frequency bin and a second exponential mean value associated with the second time frequency bin based on a second magnitude of the audio signal associated with the second time frequency bin and the first exponential mean value.

Abstract: In one aspect of the present disclosure, a tissue retraction system may include a first anchor, a second anchor, and an elongate coupling member extending between the first anchor and the second anchor. The system also may include a holder for receiving the first anchor, the second anchor, and the elongate coupling element. The holder may include a proximal portion and a distal portion. The distal portion may have a smaller width than the proximal portion such that the distal portion exerts a force on a proximal end of the first anchor during deployment of the first anchor from the holder. The force may move the first anchor into an open configuration for receiving tissue.

Abstract: Disclosed herein are therapy systems including a rolling element. The therapy systems can include a plurality of individually activatable therapy elements disposed on the rolling element. The therapy systems can include a sensor disposed on the rolling element and configured to detect a portion of the rolling element in contact with a user's body. The plurality of individually activatable therapy elements can be selectively activated based on an output of the sensor.

Abstract: Nano-electromechanical systems (NEMS) sensor devices that utilize thin electrically conductive membranes, which can be, for example, graphene membranes. The NEMS devices can have a trough shape (such as a serpentine shape arrangement) of the electrically conductive membrane. The thin, electrically conductive membrane has membrane-structures disposed upon it in an array of cavities. These membrane structures are between the thin, electrically conductive membrane and the main membrane trace. Such an arrangement increases the sensitivity of the NEMS sensor device. The electrically conductive membrane can be controllably wicked down on the edge of the oxide cavity to increase the sensitivity of the NEMS sensor device. Such NEMS sensor devices include NEMS sensor devices that are well suited to applications that measure magnetic fields that, operate below 10 kHz, such as brain-computer interfaces.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue retraction device includes a first tissue engagement member coupled to an elastic member by a coupling assembly. The coupling assembly including a first coupler body having a first end region and a first compression member. Further, the first end region of the first coupler body is configured to extend into a portion of a lumen of the elastic member and the compression member is designed to compress the elastic member onto the first coupler body such that the elastic member is fixedly engaged with the coupler body.

Abstract: A wearable system or apparatus for applying thermal therapy to a shoulder includes a number of temperature modulation devices arranged in a selected pattern. The pattern can be selected such that when the wearable system or apparatus is disposed over a shoulder, the temperature modulation devices can be symmetrically disposed over the front and the back of the shoulder. In some examples, the temperature modulation devices can provide heat and/or a cooling effect to the shoulder region.

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.

Abstract: A pool shell comprising a pool shell body including an angled feature, wherein the angled feature defines an open region on an underside of the pool shell body. The pool shell may further comprise an insert positioned in the open region for providing structural support to the angled feature. The pool shell may further comprise an overlaying member positioned over the open region such that the insert is positioned between the underside of the pool shell body and the overlaying member, wherein the overlaying member is a substantially flat material for defining an exterior ramp surface extending over the open region defined by the angled feature.

Abstract: A head assembly for a therapeutic massage device includes a battery mounted to a head portion of the head assembly and not installed within the stem portion of the head assembly. The head portion may include a heating element, and the stem portion may include features that allow a tight coupling between the head assembly and a main body of the therapeutic massage device.

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.

Abstract: A method may include storing a vector space representation of a set of concepts in a semantic ontology, wherein locations of the set of concepts in the vector space are based on weights of a neural network trained using triples from the semantic ontology; presenting a semantic search user interface including: a text input portion to receive a search query from an input device; a suggested search portion; and a search results portion; receiving, from a user computing device, the search query; converting, using at least one processor, the search query into a vector; computing, using the at least one processor, a set of possible concepts related to the search query based on a distance between the vector and other concepts in the vector space representation; and presenting the set of possible concepts related to the search query in the suggested search portion of the semantic search user interface.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue retraction device includes a first tissue engagement member coupled to an elastic member by a coupling assembly. The coupling assembly including a first coupler body having a first end region and a first compression member. Further, the first end region of the first coupler body is configured to extend into a portion of a lumen of the elastic member and the compression member is designed to compress the elastic member onto the first coupler body such that the elastic member is fixedly engaged with the coupler body.

Abstract: Customized recombinant proteins are designed and produced by cultures of Pseudomonas bacteria, including natural and recombinant silk proteins, fluorescent proteins, and elastin-like proteins (ELPs). The recombinant genes can be expressed via insertion directly into the Pseudomonas bacteria, or via the transformation of a suitably designed recombinant plasmid. Advantageously, the carbon source used as the nutrient source by the Pseudomonas bacteria is derived from non-traditional nutrient sources, such as exogenous rhamnolipids, hydrocarbons, polyolefins, polyesters, and pyrolysis products of waste plastic, e.g., pyrolysis products of polyethylene or poly (ethylene terephthalate). The waste feedstocks can be added to particularly designed growth media for sustained bacterial culture and protein production. These feedstocks allow for upcycling of plastic waste into high value protein products, such as recombinant silk fibroins.

Abstract: A pool shell comprising a pool shell body including an angled feature, wherein the angled feature defines an open region on an underside of the pool shell body. The pool shell may further comprise an insert positioned in the open region for providing structural support to the angled feature. The pool shell may further comprise an overlaying member positioned over the open region such that the insert is positioned between the underside of the pool shell body and the overlaying member, wherein the overlaying member is a substantially flat material for defining an exterior ramp surface extending over the open region defined by the angled feature.