Abstract: A cutter for cutting an implant is provided. The cutter includes a handle; a handle coupler coupled to the handle; a drill guide coupled to the handle coupler and including at least one window; a mill extending through the handle coupler and the drill guide and disposed to rotate freely therein; and a catch cup circumscribing the drill guide to maintain chips of the implant removed by the mill.

Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

Abstract: Selecting between basic and global persistent flush modes is described. In accordance with the described techniques, a system includes a data fabric in electronic communication with at least one cache and a controller configured to select between operating in a global persistent flush mode and a basic persistent flush mode based on an available flushing latency of the system, control the at least one cache to flush dirty data to the data fabric in response to a flush event trigger while operating in the global persistent flush mode, and transmit a signal to switch control to an application to flush the dirty data from the at least one cache to the data fabric while operating in the basic persistent flush mode.

Abstract: Runtime flushing to persistency in heterogenous systems is described. In accordance with the described techniques, a system may include a persistent memory in electronic communication with at least one cache and a controller configured to command the at least one cache to flush dirty data to the persistent memory in response to a dirtiness of the at least one cache reaching a cache dirtiness threshold.

Abstract: Bypass valves for pool heaters are disclosed. Embodiments may include pool heaters with a heat exchanger, a support, and an automatic bypass valve coupled to the support. The automatic bypass valve may include a cylindrical bypass shaft, and a bypass valve having a non-circular opening configured to receive the bypass shaft, where the bypass valve is configured to slide along the cylindrical bypass shaft responsive to water pressure in the heat exchanger, and where water and debris can flow through the non-circular opening when the bypass valve is in a closed position.

Abstract: A method for scoring and reporting electroencephalogram (EEG) data for use in transcranial magnetic stimulation (TMS) therapy. The method may include removing artifacts from the EEG data and determining EEG metrics from the EEG data. The method may further include determining a Brain Synchrony Index from the EEG metrics by applying a predetermined transfer function to the EEG metrics, and reporting the Brain Synchrony Index graphically.

Abstract: The techniques herein are directed generally to a “zero-knowledge” data management network. Users are able to share verifiable proof of data and/or identity information, and businesses are able to request, consume, and act on the data—all without a data storage server or those businesses ever seeing or having access to the raw sensitive information (where server-stored data is viewable only by the intended recipients, which may even be selected after storage). In one embodiment, source data is encrypted with a source encryption key (e.g., source public key), with a rekeying key being an encrypting combination of a source decryption key (e.g., source private key) and a recipient's public key. Without being able to decrypt the data, the storage server can use the rekeying key to re-encrypt the source data with the recipient's public key, to then be decrypted only by the corresponding recipient using its private key, accordingly.

Abstract: The present disclosure is directed towards systems and methods for improving analysis of sleep data by classifying users based on sleeper type. In particular, a wearable computing system can obtain a first set of motion sensor data from the motion sensor for a user during a first period. The wearable computing system can determine a sleeper type from a plurality of sleeper types for the user based on the first set of motion sensor data received from the motion sensor. The wearable computing system can select a sleep analysis model from a plurality of sleep analysis models based on the sleeper type determined for the user. The wearable computing system can use the selected sleep analysis model to analyze a second set of motion sensor data from a second period to determine one or more sleep characteristics for the user during the second period.

Abstract: A computer-assisted method for providing re-quotations for insurance coverage may include receiving a list of insurance leads corresponding to individuals who received a previous quotation for insurance coverage but did not purchase the insurance coverage and identifying a difference between the previous quotation and a new quotation. This difference may include an increase in offered insurance coverage and/or a reduction in cost. A computing device may calculate a probability for each of the individuals on the list using a regression model based, at least in part, on the identified difference. In some cases, the regression model may be associated with individual states. In other cases, the regression model may correspond to a plurality of states. The regression model may output a probability that a resident of a particular state will purchase insurance in response to a re-quotation for insurance coverage, where individuals may then be ranked based on the probability.

Abstract: An endoscopic device has a handle including an adapter, a shaft connected to the handle, and one or more wires within the handle. The adapter defines one or more openings in a side or proximal end of the adapter. The shaft has a plurality of lumens extending from a proximal end of the shaft to a distal end of the shaft. A first lumen of the plurality of lumens is a working channel for receiving a medical instrument. Each of the one or more wires enter through the one or more openings in the adapter for guiding the one or more wires to a corresponding lumen other than the first lumen and to the distal end of the shaft.

Abstract: Robotic systems for orthopedic surgery are provided. The robotic systems may include at least first and second motors coupled to each other. An output shaft of one of the motors may be connectable to a surgical tool guide. An output shaft of another of the motors may be coupled to a portion of a ball and socket joint. A corresponding portion of the ball and socket joint may be coupled to a bone mount which may be attached to a bone to mount the first and second motors to bone for performing orthopedic surgical procedures.

Abstract: A compound of general formula I wherein A is selected from the group of an unbranched or branched alky group with 1 to 12 carbon atoms, an —R1—O—R2 group, an —R1—Si(R3R4R5) group, an —R1—O—Si(R3R4R5) group, a —C(O)—O—R9—Si(R3R4R5) group, a —CH(O—R6)(O—R7) group, an —R1—CH(O—R6)(O—R7) group, or an —R1—O—C(O)—O—R8 group; SG is a protective group; R1 is a divalent hydrocarbon residue with 1 to 12 carbon atoms; R2 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R3, R4 and R5 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R6 and R7 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R8 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms; and R9 is a divalent hydrocarbon residue with 1 to 12 carbon atoms.

Abstract: The techniques herein are directed generally to a “zero-knowledge” data management network. Users are able to share verifiable proof of data and/or identity information, and businesses are able to request, consume, and act on the data—all without a data storage server or those businesses ever seeing or having access to the raw sensitive information (where server-stored data is viewable only by the intended recipients, which may even be selected after storage). In one embodiment, source data is encrypted with a source encryption key (e.g., source public key), with a rekeying key being an encrypting combination of a source decryption key (e.g., source private key) and a recipient's public key. Without being able to decrypt the data, the storage server can use the rekeying key to re-encrypt the source data with the recipient's public key, to then be decrypted only by the corresponding recipient using its private key, accordingly.

Abstract: The technology relates to partially redundant equipment architectures for vehicles able to operate in an autonomous driving mode. Aspects of the technology employ fallback configurations, such as two or more fallback sensor configurations that provide some minimum amount of field of view (FOV) around the vehicle. For instance, different sensor arrangements are logically associated with different operating domains of the vehicle. Fallback configurations for computing resources and/or power resources are also provided. Each fallback configuration may have different reasons for being triggered, and may result in different types of fallback modes of operation. Triggering conditions may relate, e.g., to a type of failure, fault or other reduction in component capability, the current driving mode, environmental conditions in the vicinity of vehicle or along a planned route, or other factors.

Abstract: A heating element for a vaporizer cartridge is provided. The vaporizer cartridge may include a reservoir containing vaporizable material and a wicking element in fluid communication with the reservoir. The heating element may include a heating portion, a cartridge contact, and a leg. The heating portion includes at least two tines spaced apart from one another. The cartridge contact may be in in electrical communication with a power source. The leg extends between the heating portion and the cartridge contact. The heating portion may be crimped around the wicking element such that the heating portion secures the wicking element to the heating element and contacts at least two surfaces of the wicking element.

Abstract: Devices, systems and processes for an integrated internal and external camera system that enhances the passenger experience in vehicles are described. One example method for enhancing a passenger experiences includes capturing a first set of images of an area around the vehicle using an external camera system, capturing a second set of images of one or more passengers inside the vehicle using an internal camera system, recognizing at least one gesture made by the one or more passengers based on the second set of images, identifying an object or a location external to the vehicle based on the first set of images and the at least one gesture, and displaying information related to the object or the location to the one or more passengers.

Abstract: Disclosed herein are systems, devices, and processes for gesture detection. A method includes capturing a series of images. The method includes generating motion isolation information based on the series of images. The method includes generating a composite image based on the motion isolation information. The method includes determining a gesture based on the composite image. The processes described herein may include the use of convolutional neural networks on a series of time-related images to perform gesture detection on embedded systems or devices.

Abstract: A recharging and medication storage hub for a re-usable drug-delivery device is provided. According to some embodiments, the hub comprises a housing defining a port sized to receive at least part of the re-usable drug-delivery device, a charging station disposed on the housing configured to charge a rechargeable power source mounted on the drug-delivery device, and a medication storage chamber disposed in alignment with the port, the storage chamber configured to store a single-use medication cartridge. When at least part of the drug-delivery device is inserted through the port and into the medication storage chamber, a coupling mechanism is configured to releasably couple with and withdraw the medication cartridge from the medication storage chamber. In some embodiments, the hub may further comprise a temperature-changing device configured to control an interior temperature of the medication storage chamber.

Abstract: Various examples are provided related to self-assembled carbon nanotube (CNT) films. In one example, a method includes providing a CNT dispersion solution including an aqueous solution comprising a quantity of amphiphilic pendant polymer dispersant; and a plurality of carbon nanotubes in the aqueous solution, the pendant polymer dispersant enabling CNT self-assembly. The method further includes forming a self-assembled CNT film on a surface of a substrate using the CNT dispersion solution.