Patents by Inventor Alexander L. Ruchelman

Alexander L. Ruchelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4?-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 10385037
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: August 20, 2019
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20190135780
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 9, 2019
    Inventors: Hon-Wah Man, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 10189814
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: January 29, 2019
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • 3-(1-OXO-4-((4-((3-OXOMORPHOLINO)METHYL)BENZYL)OXY)ISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND ISOTOPOLOGUES THEREOF
    Publication number: 20180243285
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, e.g., 3-(1-oxo-4-((4-((3-oxomorpholino)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione, or an isotopologue thereof, or an enantiomer or a mixture of enantiomers thereof. Pharmaceutical compositions comprising and methods for using the compounds are also disclosed.
    Type: Application
    Filed: January 26, 2018
    Publication date: August 30, 2018
    Inventors: Hon-Wah Man, Alexander L. Ruchelman
  • 4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20180155316
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 7, 2018
    Inventors: Alexander L. Ruchelman, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • 4?-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 9920027
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: March 20, 2018
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20180037567
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 8, 2018
    Inventors: Hon-Wah MAN, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 9828361
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 28, 2017
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 9822094
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 21, 2017
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • 5-substituted isoindoline compounds
    Patent number: 9801868
    Abstract: This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: October 31, 2017
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Roger Shen-Chu Chen, Alexander L. Ruchelman
  • Isoindoline compounds and methods of their use
    Patent number: 9796698
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: October 24, 2017
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Alexander L. Ruchelman
  • Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
    Patent number: 9688623
    Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 27, 2017
    Assignee: Celgene Corporation
    Inventors: Jasti Venkateswaralu, Chinnapillai Rajendiran, Nallamaddi Ravikumar Reddy, Terrence Joseph Connolly, Alexander L. Ruchelman, Jeffrey Eckert, Anthony Joseph Frank
  • PROCESSES FOR THE PREPARATION OF (S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHANESULFONYLETHYLAMINE
    Publication number: 20170129852
    Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.
    Type: Application
    Filed: January 25, 2017
    Publication date: May 11, 2017
    Inventors: Jasti Venkateswaralu, Chinnapillai Rajendiran, Nallamaddi Ravikumar Reddy, Terrence Joseph Connolly, Alexander L. Ruchelman, Jeffrey Eckert, Anthony Joseph Frank
  • ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20170088538
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Application
    Filed: December 12, 2016
    Publication date: March 30, 2017
    Inventors: George W. Muller, Alexander L. Ruchelman
  • Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
    Patent number: 9586897
    Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: March 7, 2017
    Assignee: Celgene Corporation
    Inventors: Jasti Venkateswaralu, Chinnapillai Rajendiran, Nallamaddi Ravikumar Reddy, Terrence Joseph Connolly, Alexander L. Ruchelman, Jeffrey Eckert, Anthony Joseph Frank
  • Isoindoline compounds and methods of their use
    Patent number: 9550766
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: January 24, 2017
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Alexander L. Ruchelman
  • 5-SUBSTITUTED ISOINDOLINE COMPOUNDS
    Publication number: 20160346264
    Abstract: This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: August 10, 2016
    Publication date: December 1, 2016
    Inventors: George W. Muller, Roger Shen-Chu Chen, Alexander L. Ruchelman
  • 5-substituted isoindoline compounds
    Patent number: 9447070
    Abstract: This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: September 20, 2016
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Roger Shen-Chu Chen, Alexander L. Ruchelman
  • Processes for the preparation of isoindole compounds and isotopologues thereof
    Patent number: 9434689
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic asymmetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: September 6, 2016
    Assignee: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, Kelvin H. Y. Yong, Chengmin Zhang
  • 4?-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: RE46639
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: December 19, 2017
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen