Patents by Inventor Alexander L. Ruchelman

Alexander L. Ruchelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20160159768
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 9, 2016
    Inventors: Hon-Wah MAN, Roger Shen-Chu CHEN, George W. MULLER, Alexander L. RUCHELMAN, Ehab M. KHALIL, Weihong ZHANG
  • ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20160159772
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 9, 2016
    Inventors: Hon-Wah MAN, Roger Shen-Chu CHEN, George W. MULLER, Alexander L. RUCHELMAN, Ehab M. KHALIL, Weihong ZHANG
  • ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20160115161
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Application
    Filed: November 6, 2015
    Publication date: April 28, 2016
    Inventors: George W. MULLER, Alexander L. RUCHELMAN
  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 9309219
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: April 12, 2016
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4)-yl)piperidine-2,6-dione
    Patent number: 9303014
    Abstract: Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 5, 2016
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, Benjamin M. Cohen, Anusuya Choudhury, Matthew M. Kreilein, William W. Leong, Hon-Wah Man
  • Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4)-yl)piperidine-2,6-dione
    Patent number: 9266858
    Abstract: Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: February 23, 2016
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, Benjamin M. Cohen, Anusuya Choudhury, Matthew M. Kreilein, William W. Leong, Hon-Wah Man
  • PROCESSES FOR THE PREPARATION OF (S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHANESULFONYLETHYLAMINE
    Publication number: 20160031808
    Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 4, 2016
    Inventors: Jasti Venkateswaralu, Chinnapillai Rajendiran, Nallamaddi Ravikumar Reddy, Terrence Joseph Connolly, Alexander L. Ruchelman, Jeffrey Eckert, Anthony Joseph Frank
  • 4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20160024048
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: October 2, 2015
    Publication date: January 28, 2016
    Inventors: Alexander L. RUCHELMAN, George W. MULLER, Hon-Wah MAN, Roger Shen-Chu CHEN
  • SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE
    Publication number: 20160009685
    Abstract: Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 24, 2015
    Publication date: January 14, 2016
    Inventors: Alexander L. RUCHELMAN, Benjamin M. COHEN, Anusuya CHOUDHURY, Matthew M. KREILEIN, William W. LEONG, Hon-Wah MAN
  • Isoindoline compounds and methods of their use
    Patent number: 9227954
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: January 5, 2016
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Alexander L. Ruchelman
  • Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
    Patent number: 9187417
    Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 17, 2015
    Assignee: Celgene Corporation
    Inventors: Jasti Venkateswaralu, Chinnapillai Rajendiran, Nallamaddi Ravikumar Reddy, Terrence Joseph Connolly, Alexander L. Ruchelman, Jeffrey Eckert, Anthony Joseph Frank
  • 4?-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 9181216
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: November 10, 2015
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE
    Publication number: 20150274694
    Abstract: Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 10, 2015
    Publication date: October 1, 2015
    Inventors: Alexander L. RUCHELMAN, Benjamin M. COHEN, Anusuya CHOUDHURY, Matthew M. KREILEIN, William W. LEONG, Hon-Wah MAN
  • Processes for preparing isoindoline-1,3-dione compounds
    Patent number: 9133161
    Abstract: Provided herein are processes for preparing an isoindoline-1,3-dione compound, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: September 15, 2015
    Assignee: Celgene Corporation
    Inventors: John F. Traverse, Gregg Brian Feigelson, Alexander L. Ruchelman, Jihong Liu, Hongfeng Liu, Chengjun Ma, Danyang Liu, Shunxiang Zhang
  • Asymmetric synthetic processes for the preparation of aminosulfone compounds
    Patent number: 9126906
    Abstract: Processes for synthesizing aminosulfone compounds are provided. The processes provided herein utilize asymmetric reduction reactions, e.g., asymmetric hydrogenation, of protected or unprotected enamine or ketone substrates. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: September 8, 2015
    Assignee: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, William W. Leong
  • PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF
    Publication number: 20150183739
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Application
    Filed: March 9, 2015
    Publication date: July 2, 2015
    Inventors: Terrence J. CONNOLLY, Alexander L. RUCHELMAN, Kelvin H.Y. YONG, Chengmin ZHANG
  • Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4)-yl)piperidine-2,8-dione
    Patent number: 9067912
    Abstract: Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: June 30, 2015
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, Benjamin M. Cohen, Anusuya Choudhury, Matthew M. Kreilein, William W. Leong, Hon-Wah Man
  • Processes for the preparation of isoindole compounds and isotopologues thereof
    Patent number: 8981117
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: March 17, 2015
    Assignee: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, Kelvin H. Y. Yong, Chengmin Zhang
  • 5-SUBSTITUTED ISOINDOLINE COMPOUNDS
    Publication number: 20150005303
    Abstract: This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: September 18, 2014
    Publication date: January 1, 2015
    Inventors: George W. MULLER, Roger Shen-Chu CHEN, Alexander L. RUCHELMAN
  • SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE
    Publication number: 20140330016
    Abstract: Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 30, 2014
    Publication date: November 6, 2014
    Applicant: CELGENE CORPORATION
    Inventors: Alexander L. RUCHELMAN, Benjamin M. COHEN, Anusuya CHOUDHURY, Matthew M. KREILEIN, William W. LEONG, Hon-Wah MAN