Patents by Inventor Alexander L. Ruchelman

Alexander L. Ruchelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-substituted isoindoline compounds
    Patent number: 8877780
    Abstract: This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: November 4, 2014
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Roger Shen-Chu Chen, Alexander L. Ruchelman, Hon-Wah Man, Weihong Zhang, Ehab M. Khalil
  • PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF
    Publication number: 20140081032
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 20, 2014
    Applicant: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, Kelvin H.Y. Yong, Chengmin Zhang
  • 4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20140073669
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 13, 2014
    Inventors: Alexander L. RUCHELMAN, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS
    Publication number: 20140031552
    Abstract: Provided herein are processes for preparing an isoindoline-1,3-dione compound, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof.
    Type: Application
    Filed: July 26, 2013
    Publication date: January 30, 2014
    Applicant: Celgene Corporation
    Inventors: John F. TRAVERSE, Gregg Brian FEIGELSON, Alexander L. RUCHELMAN, Jihong LIU, Liu HONGFENG, Chengjun MA, Danyang LIU, Steven ZHANG
  • 4?-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 8614328
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: December 24, 2013
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 8518972
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: August 27, 2013
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Roger Shen-Chu Chen, Weihong Zhang
  • ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS
    Publication number: 20130217919
    Abstract: Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.
    Type: Application
    Filed: February 20, 2013
    Publication date: August 22, 2013
    Applicant: CELGENE CORPORATION
    Inventors: Terrence J. CONNOLLY, Alexander L. RUCHELMAN, William W. LEONG
  • Isoindole-imide compounds and compositions comprising and methods of using the same
    Patent number: 8481568
    Abstract: This invention relates to isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: July 9, 2013
    Assignee: Celgene Corporation
    Inventors: George Muller, Roger Shen-Chu Chen, Hon-Wah Man, Alexander L. Ruchelman
  • Solubilized topoisomerase poisons
    Patent number: 8389721
    Abstract: The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: March 5, 2013
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • Isoindoline compounds and methods of their use
    Patent number: 8318773
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: November 27, 2012
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Alexander L. Ruchelman
  • ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20120252843
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Application
    Filed: June 11, 2012
    Publication date: October 4, 2012
    Inventors: George W. Muller, Alexander L. Ruchelman
  • Isoindoline compounds and methods of their use
    Patent number: 8222249
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: July 17, 2012
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Alexander L. Ruchelman
  • 4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20120165536
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: March 1, 2012
    Publication date: June 28, 2012
    Inventors: Alexander L. RUCHELMAN, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20120122865
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Application
    Filed: January 26, 2012
    Publication date: May 17, 2012
    Inventors: George W. MULLER, Alexander L. Ruchelman
  • 4?-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
    Patent number: 8153659
    Abstract: Provided are 4?-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: April 10, 2012
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, George W. Muller, Hon-Wah Man, Roger Shen-Chu Chen
  • Isoindoline compounds and methods of their use
    Patent number: 8129375
    Abstract: Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: March 6, 2012
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Alexander L. Ruchelman
  • Arylmethoxy Isoindoline Derivatives and Compositions Comprising and Methods of Using the Same
    Publication number: 20110196150
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: February 10, 2011
    Publication date: August 11, 2011
    Inventors: Hon-Wah Man, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Roger Shen-Chu Chen, Weihong Zhang
  • ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20110144158
    Abstract: This invention relates to isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: February 17, 2011
    Publication date: June 16, 2011
    Inventors: George W. MULLER, Roger Shen-Chu Chen, Hon-Wah Man, Alexander L. Ruchelman
  • SOLUBILIZED TOPOISOMERASE POISONS
    Publication number: 20110136812
    Abstract: The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 9, 2011
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
  • Topoisomerase-targeting agents
    Patent number: 7858627
    Abstract: The invention provides compounds of formula I or formula II: wherein: the bond represented by is a single bond or a double bond, and R1—R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I or II, processes for preparing compounds of formula I or II, intermediates useful for preparing compounds of formula I or II, and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula I or II.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: December 28, 2010
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu