Patents by Inventor Alfred Liang

Alfred Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190314289
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Application
    Filed: January 22, 2018
    Publication date: October 17, 2019
    Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
  • Publication number: 20170056329
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Application
    Filed: May 3, 2016
    Publication date: March 2, 2017
    Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
  • Publication number: 20160375011
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Inventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
  • Publication number: 20160354364
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Inventors: Alfred Liang, Franklin Johnson, Xiaohong Qi
  • Publication number: 20160058755
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
    Type: Application
    Filed: November 5, 2015
    Publication date: March 3, 2016
    Inventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
  • Publication number: 20150297527
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
    Type: Application
    Filed: January 15, 2015
    Publication date: October 22, 2015
    Inventors: Alfred Liang, Franklin Johnson, Xiaohong Qi
  • Publication number: 20150104519
    Abstract: Provided herein are formulations and methods for treating pain in human beings. Also provided are optimal ratios at which an opioid and an opioid antagonist may be combined for administration to humans such that the opioid activity is inhibited. These ratios may also be used to formulate compositions containing both an opioid and an opioid antagonist within a single pharmaceutical dosing unit.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 16, 2015
    Inventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
  • Publication number: 20150024058
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Application
    Filed: October 1, 2014
    Publication date: January 22, 2015
    Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
  • Publication number: 20140328930
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Application
    Filed: January 9, 2014
    Publication date: November 6, 2014
    Applicant: Alpharma Pharmaceuticals, LLC
    Inventors: Alfred Liang, Joseph Stauffer, James Jones
  • Patent number: 8877247
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: November 4, 2014
    Assignee: Alpharma Pharmaceuticals LLC
    Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
  • Patent number: 8846104
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: September 30, 2014
    Assignee: Alpharma Pharmaceuticals LLC
    Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
  • Publication number: 20140056975
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
    Type: Application
    Filed: November 4, 2013
    Publication date: February 27, 2014
    Applicant: Alpharma Pharmaceuticals LLC
    Inventors: Alfred Liang, Francis Joseph Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
  • Publication number: 20140037721
    Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicant: Alpharma pharmaceuticals LLC
    Inventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
  • Patent number: 8623418
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: January 7, 2014
    Assignee: Alpharma Pharmaceuticals LLC
    Inventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
  • Publication number: 20130072514
    Abstract: The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) <724>, is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.
    Type: Application
    Filed: March 6, 2012
    Publication date: March 21, 2013
    Applicant: Alpharma Pharmaceuticals, LLC
    Inventors: Garth Boehm, Alfred Liang
  • Publication number: 20120201895
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Application
    Filed: February 13, 2012
    Publication date: August 9, 2012
    Inventors: Frank Matthews, Garth Bohm, Lijuan Tang, Alfred Liang
  • Publication number: 20120189705
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are . also provided.
    Type: Application
    Filed: March 23, 2012
    Publication date: July 26, 2012
    Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
  • Publication number: 20120121667
    Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.
    Type: Application
    Filed: January 25, 2012
    Publication date: May 17, 2012
    Inventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
  • Patent number: 8163797
    Abstract: The present invention provides oral pravastatin formulations comprising a physical mixture of pravastatin and at least one pharmaceutically-acceptable excipient, wherein the composition for at least 6 months after its preparation is stable and has a pH of greater than about 7 to less than 9, as well as methods for the preparation and use of these stable formulations.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: April 24, 2012
    Assignee: Actavis Elizabeth LLC
    Inventor: Alfred Liang
  • Patent number: 8158156
    Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: April 17, 2012
    Assignee: Alpharma Pharmaceuticals, LLC
    Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang