Abstract: Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and to methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.

Abstract: Oral drug complex microparticles containing: a pharmaceutical active having a nitrogen moiety and an anionic methacrylic acid copolymer; wherein the oral drug complex micropaticles resist dissolution or dissociation upon exposure to saliva, but which rapidly dissociate in gastric acid and which rapidly dissolve in intestinal fluid. Oral drug delivery devices containing said oral drug complex microparticles are provided. Processes for producing said oral drug complex microparticles and methods for treating patients including administering said oral drug delivery devices thereto are also provided.

Abstract: Drug delivery devices for administering an active agent or a combination of active agents to a subject are provided.

Abstract: Quick dissolving oral mucosal drug delivery devices having a mucosal surface-coat-forming inner layer disposed between two moisture barrier coating layers for administering an active agent or combination of active agents to a subject are provided. Methods for making such quick dissolving oral mucosal drug delivery devices and to methods for using such quick dissolving oral mucosal drug delivery devices offering the measured and controlled release of an active agent or combination of active agents to a subject are also provided.

Abstract: Dosage forms of a nicotine delivery system are disclosed in which a mucoadhesive film, made up of one or more non-microbial hydrocolloid(s) and an effective dose of nicotine, dissolves when applied intraorally to release the nicotine which is absorbed through the oramucosae and directly reaches systemic circulation. Methods for preparing various versions of the dosage forms are disclosed. Methods to assist smoking cessation or provide substitutes for smoking by administrating the dosage form are also provided.

Abstract: The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.