Patents by Inventor Alfred Liang
Alfred Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20120039962Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: October 21, 2011Publication date: February 16, 2012Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Joseph Stauffer, James Jones
-
Publication number: 20100266645Abstract: Provided herein are formulations and methods for treating pain in human beings. Also provide are optimal ratios at which an opioid and an opioid antagonist may be combined for administration to humans such that the opioid activity is inhibited. These ratios may also be used to formulate compositions containing both an opioid and an opioid antagonist within a single pharmaceutical dosing unit.Type: ApplicationFiled: December 16, 2008Publication date: October 21, 2010Inventors: Alfred Liang, Frank Matthews, Garth Boehm, Joseph Stauffer
-
Publication number: 20100152221Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.Type: ApplicationFiled: December 16, 2008Publication date: June 17, 2010Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
-
Publication number: 20100151014Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.Type: ApplicationFiled: December 16, 2008Publication date: June 17, 2010Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
-
Publication number: 20100143483Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: February 22, 2010Publication date: June 10, 2010Applicant: ALPHARMA PHARMACEUTICALS, LLC.Inventors: Frank MATTHEWS, Garth Boehm, Lijuan Tang, Alfred Liang
-
Patent number: 7682634Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: GrantFiled: March 6, 2009Date of Patent: March 23, 2010Assignee: Alpharma Pharmaceuticals, LLCInventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
-
Patent number: 7682633Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: GrantFiled: March 6, 2009Date of Patent: March 23, 2010Assignee: Alpharma Pharmaceuticals, LLCInventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
-
Publication number: 20090196890Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.Type: ApplicationFiled: December 17, 2008Publication date: August 6, 2009Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Franklin Johnson, Xiaohong Qi
-
Publication number: 20090162451Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: March 6, 2009Publication date: June 25, 2009Applicant: ALPHARMA PHARMACEUTICALS, LLC.Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
-
Publication number: 20090162450Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: March 6, 2009Publication date: June 25, 2009Applicant: ALPHARMA PHARMACEUTICALS, LLC.Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
-
Publication number: 20090131466Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: September 4, 2008Publication date: May 21, 2009Applicant: ALPHARMA, INC.Inventors: Alfred Liang, Joseph Stauffer, James Jones
-
Publication number: 20080233197Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: June 19, 2007Publication date: September 25, 2008Inventors: Francis Joseph Matthews, Alfred Liang, Boehm Garth
-
Publication number: 20080233156Abstract: Provided herein is a method of treating a condition in a host that is responsive to an agonist, the method comprising administering to the host a multi-layer pharmaceutical composition comprising the agonist and an antagonist thereof, wherein the agonist and antagonist are not in direct contact with one another in the intact form of the composition.Type: ApplicationFiled: October 10, 2007Publication date: September 25, 2008Inventors: Frank Matthews, Alfred Liang, Frank Johnson
-
Publication number: 20070298090Abstract: Dosage forms of a nicotine delivery system are disclosed in which a mucoadhesive film, made up of one or more non-microbial hydrocolloid(s) and an effective dose of nicotine, dissolves when applied intraorally to release the nicotine which is absorbed through the oramucosac and directly reaches systemic circulation. Methods for preparing various versions of the dosage forms are disclosed. Methods to assist smoking cessation or provide substitutes for smoking by administrating the dosage form are also provided.Type: ApplicationFiled: September 7, 2007Publication date: December 27, 2007Applicant: LAVIPHARM LABORATORIES, INC.Inventors: Li-Lan CHEN, Alfred LIANG
-
Publication number: 20070087981Abstract: The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.Type: ApplicationFiled: October 19, 2006Publication date: April 19, 2007Applicant: Lavipharm Laboratories, Inc.Inventors: Li-Lan Chen, Li Tao, Alfred Liang
-
Patent number: 7138135Abstract: Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.Type: GrantFiled: June 24, 2004Date of Patent: November 21, 2006Assignee: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, Li Tao, Alfred Liang, Xu Zheng
-
Patent number: 7125564Abstract: The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.Type: GrantFiled: February 8, 2002Date of Patent: October 24, 2006Assignee: Lavipharm Laboratories, Inc.Inventors: Li-Lan H. Chen, Li Tao, Alfred Liang
-
Publication number: 20050143460Abstract: The present invention provides oral pravastatin formulations comprising a physical mixture of pravastatin and at least one pharmaceutically-acceptable excipient, wherein the composition for at least 6 months after its preparation is stable and has a pH of greater than about 7 to less than 9, as well as methods for the preparation and use of these stable formulations.Type: ApplicationFiled: May 7, 2004Publication date: June 30, 2005Applicant: ALPHARMA, INC.Inventor: Alfred Liang
-
Publication number: 20050020613Abstract: The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) <724>, is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; less than about 10% within about 10 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.Type: ApplicationFiled: September 22, 2003Publication date: January 27, 2005Applicant: ALPHARMA, INC.Inventors: Garth Boehm, Alfred Liang
-
Publication number: 20040234578Abstract: Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and to methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.Type: ApplicationFiled: June 24, 2004Publication date: November 25, 2004Inventors: Li-Lan H. Chen, Li Tao, Alfred Liang, Xu Zheng