Patents by Inventor Alfredo C. Castro

Alfredo C. Castro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TEAD INHIBITORS AND USES THEREOF
    Publication number: 20240083854
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 16, 2023
    Publication date: March 14, 2024
    Inventor: Alfredo C. CASTRO
  • TEAD inhibitors and uses thereof
    Patent number: 11925651
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: August 2, 2022
    Date of Patent: March 12, 2024
    Assignee: Ikena Oncology, Inc.
    Inventor: Alfredo C. Castro
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20240050437
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Application
    Filed: November 30, 2022
    Publication date: February 15, 2024
    Inventors: Jeffery L. Kutok, David G. Winkler, Vito J. Palombella, Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • MEK inhibitors and uses thereof
    Patent number: 11878958
    Abstract: The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: May 25, 2023
    Date of Patent: January 23, 2024
    Assignee: Ikena Oncology, Inc.
    Inventors: Alfredo C. Castro, Michael J. Burke, Thomas A. Wynn, Sabine K. Ruppel, Sergio L. Santillana Soto, Eric Haines, Lan Xu, Oksana Zavidij
  • MEK INHIBITORS AND USES THEREOF
    Publication number: 20230382863
    Abstract: The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 30, 2023
    Inventors: Alfredo C. CASTRO, Michael J. BURKE, Thomas A. WYNN, Sabine K. RUPPEL, Sergio L. SANTILLANA SOTO, Eric HAINES, Lan XU, Oksana ZAVIDIJ
  • ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF
    Publication number: 20230295147
    Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 9, 2023
    Publication date: September 21, 2023
    Inventors: Alfredo C. CASTRO, Karen J. McGovern, Michael Burke
  • Tead inhibitors and uses thereof
    Patent number: 11760728
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 3, 2022
    Date of Patent: September 19, 2023
    Assignee: IKENA ONCOLOGY, INC.
    Inventor: Alfredo C. Castro
  • POLYMORPHIC COMPOUNDS AND USES THEREOF
    Publication number: 20230286990
    Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which the aryl hydrocarbon receptor (AHR) is implicated, by the administration of small molecule therapeutics which act as inhibitors of AHR.
    Type: Application
    Filed: January 19, 2023
    Publication date: September 14, 2023
    Inventors: Alfredo C. Castro, James Martin Nolan, III, Sarah Jean Bethune, Corinne Marie Folberth
  • TEAD INHIBITORS AND USES THEREOF
    Publication number: 20230148061
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 2, 2022
    Publication date: May 11, 2023
    Inventor: Alfredo C. CASTRO
  • Combinations of RAD51 and PARP inhibitors
    Patent number: 11607404
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula: in combination with a PARP inhibitor, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: March 21, 2023
    Assignee: Cyteir Therapeutics, Inc.
    Inventors: Alfredo C. Castro, Melinda Day, Tyler Maclay, Casey Cameron McComas, Kevin Mills, Joseph Vacca
  • Aryl hydrocarbon receptor (AHR) agonists and uses thereof
    Patent number: 11608329
    Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: March 21, 2023
    Assignee: IKENA ONCOLOGY, INC.
    Inventors: Alfredo C. Castro, Karen J. McGovern, Michael Burke
  • Methods of use of cyclopamine analogs
    Patent number: 11602527
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: March 14, 2023
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
  • Solid forms of (R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[ 1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine maleate as aryl hydrocarbon receptor (AHR) inhibitors
    Patent number: 11591339
    Abstract: The present invention provides solid forms of (R)—N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine maleate (Compound 2) represented by the formula:
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: February 28, 2023
    Assignee: IKENA ONCOLOGY, INC.
    Inventors: Alfredo C. Castro, James Martin Nolan, III, Sarah Jean Bethune, Corinne Marie Folberth
  • INDOLE AHR INHIBITORS AND USES THEREOF
    Publication number: 20230028336
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 6, 2022
    Publication date: January 26, 2023
    Inventors: Alfredo C. CASTRO, Catherine A. EVANS
  • AHR INHIBITORS AND USES THEREOF
    Publication number: 20230026232
    Abstract: The present invention provides AHR inhibitors, formulations and unit dosage forms thereof, and methods of use thereof.
    Type: Application
    Filed: November 25, 2020
    Publication date: January 26, 2023
    Inventors: Alfredo C. Castro, James Martin NOLAN, III, Xiaoyan Michelle ZHANG, Jason SAGER
  • AHR inhibitors and uses thereof
    Patent number: 11555026
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: January 17, 2023
    Assignee: IKENA ONCOLOGY, INC.
    Inventors: Alfredo C. Castro, Catherine Anne Evans
  • Heterocyclic compounds and uses thereof
    Patent number: 11541059
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: January 3, 2023
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Jeffery L. Kutok, David G. Winkler, Vito J. Palombella, Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20220372038
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Application
    Filed: March 15, 2021
    Publication date: November 24, 2022
    Inventors: Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • TEAD inhibitors and uses thereof
    Patent number: 11458149
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: October 4, 2022
    Assignee: IKENA ONCOLOGY, INC.
    Inventor: Alfredo C. Castro
  • TEAD INHIBITORS AND USES THEREOF
    Publication number: 20220251048
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 3, 2022
    Publication date: August 11, 2022
    Inventor: Alfredo C. CASTRO