Patents by Inventor Alfredo C. Castro

Alfredo C. Castro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136591
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Application
    Filed: August 29, 2024
    Publication date: May 1, 2025
    Inventors: Alfredo C. CASTRO, Casey Cameron MCCOMAS, Joseph VACCA, Tyler MACLAY
  • Publication number: 20250122205
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 12, 2024
    Publication date: April 17, 2025
    Inventors: Alfredo C. Castro, Catherine A. Evans
  • Publication number: 20250082614
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat pancreatic cancer.
    Type: Application
    Filed: July 9, 2024
    Publication date: March 13, 2025
    Inventors: Alfredo C. CASTRO, Melinda DAY, Tyler MACLAY, Casey Cameron MCCOMAS, Kevin MILLS, Joseph VACCA
  • Publication number: 20250011315
    Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 24, 2024
    Publication date: January 9, 2025
    Inventors: Alfredo C. Castro, Karen J. McGovern, Michael Burke
  • Patent number: 12162884
    Abstract: The present invention provides freebase and salt forms of (R)-N-(2-(5-fluoropyridin-3-yl)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine, which act as inhibitors of AHR, and compositions and methods thereof, useful for treating various conditions in which the aryl hydrocarbon receptor (AHR) is implicated.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: December 10, 2024
    Assignee: Ikena Oncology, Inc.
    Inventors: Alfredo C. Castro, James Martin Nolan, III, Sarah Jean Bethune, Corinne Marie Folberth
  • Patent number: 12152032
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: November 26, 2024
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • Publication number: 20240358723
    Abstract: The present invention provides co-crystal and salt forms, and compositions and methods thereof, useful for treating various diseases, disorders or conditions in which EP4 prostaglandin receptors are implicated in the mediation of a proliferative disorder, by the administration of small molecule therapeutics acting as inhibitors of prostaglandin EP4 receptor activity.
    Type: Application
    Filed: April 2, 2024
    Publication date: October 31, 2024
    Inventors: Alfredo C. CASTRO, David T. JONAITIS
  • Patent number: 12077542
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: September 3, 2024
    Assignee: Ikena Oncology, Inc.
    Inventors: Alfredo C. Castro, Catherine A. Evans
  • Patent number: 12064419
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat pancreatic cancer.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: August 20, 2024
    Assignee: Cyteir Therapeutics, Inc.
    Inventors: Alfredo C. Castro, Melinda Day, Tyler Maclay, Casey Cameron McComas, Kevin Mills, Joseph Vacca
  • Publication number: 20240261288
    Abstract: The present invention provides TEAD inhibitors, and methods of use thereof.
    Type: Application
    Filed: January 25, 2022
    Publication date: August 8, 2024
    Inventors: Alfredo C. CASTRO, Michael BURKE, Benjamin AMIDON, Hyejin FROSCH
  • Publication number: 20240254120
    Abstract: The present invention provides N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide compositions, and the use thereof for treating a proliferative disorder.
    Type: Application
    Filed: December 13, 2023
    Publication date: August 1, 2024
    Inventors: Mark MANFREDI, Jeffrey Ecsedy, Alfredo C. Castro, Yoshiyuki Okumura
  • Patent number: 12030876
    Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: February 9, 2023
    Date of Patent: July 9, 2024
    Assignee: Ikena Oncology, Inc.
    Inventors: Alfredo C. Castro, Karen J. McGovern, Michael Burke
  • Publication number: 20240190822
    Abstract: The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 13, 2023
    Publication date: June 13, 2024
    Inventors: Alfredo C. CASTRO, Michael J. Burke, Thomas A. Wynn, Sabine K. Ruppel, Sergio L. Santillana Soto, Eric Haines, Lan Xu, Oksana Zavidij
  • Publication number: 20240148740
    Abstract: The present invention provides AHR inhibitors, and methods of use thereof.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 9, 2024
    Inventors: Alfredo C. CASTRO, Xiaoyan Michelle ZHANG, Jason SAGER, Karen J. MCGOVERN
  • Publication number: 20240083854
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 16, 2023
    Publication date: March 14, 2024
    Inventor: Alfredo C. CASTRO
  • Patent number: 11925651
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: August 2, 2022
    Date of Patent: March 12, 2024
    Assignee: Ikena Oncology, Inc.
    Inventor: Alfredo C. Castro
  • Publication number: 20240050437
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Application
    Filed: November 30, 2022
    Publication date: February 15, 2024
    Inventors: Jeffery L. Kutok, David G. Winkler, Vito J. Palombella, Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • Patent number: 11878958
    Abstract: The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: May 25, 2023
    Date of Patent: January 23, 2024
    Assignee: Ikena Oncology, Inc.
    Inventors: Alfredo C. Castro, Michael J. Burke, Thomas A. Wynn, Sabine K. Ruppel, Sergio L. Santillana Soto, Eric Haines, Lan Xu, Oksana Zavidij
  • Publication number: 20230382863
    Abstract: The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 30, 2023
    Inventors: Alfredo C. CASTRO, Michael J. BURKE, Thomas A. WYNN, Sabine K. RUPPEL, Sergio L. SANTILLANA SOTO, Eric HAINES, Lan XU, Oksana ZAVIDIJ
  • Publication number: 20230295147
    Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 9, 2023
    Publication date: September 21, 2023
    Inventors: Alfredo C. CASTRO, Karen J. McGovern, Michael Burke