Patents by Inventor Alfredo C. Castro

Alfredo C. Castro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole AHR inhibitors and uses thereof
    Patent number: 11358969
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: June 14, 2022
    Assignee: IKENA ONCOLOGY, INC.
    Inventors: Alfredo C. Castro, Catherine A. Evans
  • INDOLE AHR INHIBITORS AND USES THEREOF
    Publication number: 20220144839
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 16, 2019
    Publication date: May 12, 2022
    Inventor: Alfredo C. CASTRO
  • RAD51 inhibitors
    Patent number: 11291655
    Abstract: This application is directed to inhibitors of RAD51, and methods for their use, such as to treat or prevent conditions involving mitochondrial defects.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: April 5, 2022
    Assignee: Cyteir Therapeutics, Inc.
    Inventors: Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca
  • Tead inhibitors and uses thereof
    Patent number: 11274082
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: March 15, 2022
    Assignee: IKENA ONCOLOGY, INC.
    Inventor: Alfredo C. Castro
  • RAD51 INHIBITORS
    Publication number: 20220056022
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Application
    Filed: June 30, 2021
    Publication date: February 24, 2022
    Inventors: Alfredo C. CASTRO, Casey Cameron MCCOMAS, Joseph VACCA, Tyler MACLAY
  • POLYMORPHIC COMPOUNDS AND USES THEREOF
    Publication number: 20210315909
    Abstract: The present invention provides co-crystal and salt forms, and compositions and methods thereof, useful for treating various diseases, disorders or conditions in which EP4 prostaglandin receptors are implicated in the mediation of a proliferative disorder, by the administration of small molecule therapeutics acting as inhibitors of prostaglandin EP4 receptor activity.
    Type: Application
    Filed: July 11, 2019
    Publication date: October 14, 2021
    Inventors: Alfredo C. CASTRO, David T. JONAITIS
  • ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF
    Publication number: 20210300912
    Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 18, 2020
    Publication date: September 30, 2021
    Inventors: Alfredo C. Castro, Karen J. McGovern, Michael Burke
  • EP4 INHIBITORS AND SYNTHESIS THEREOF
    Publication number: 20210300921
    Abstract: The present invention provides N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide compositions, and the use thereof for treating a proliferative disorder.
    Type: Application
    Filed: July 11, 2019
    Publication date: September 30, 2021
    Inventors: Mark MANFREDI, Jeffrey ECSEDY, Alfredo C. CASTRO, Yoshiyuki OKUMURA
  • METHODS OF USE OF CYCLOPAMINE ANALOGS
    Publication number: 20210275508
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: September 28, 2020
    Publication date: September 9, 2021
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
  • POLYMORPHIC COMPOUNDS AND USES THEREOF
    Publication number: 20210253579
    Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which the aryl hydrocarbon receptor (AHR) is implicated, by the administration of small molecule therapeutics which act as inhibitors of AHR.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 19, 2021
    Inventors: Alfredo C. CASTRO, James Martin NOLAN, III, Sarah Jean BETHUNE, Corinne Marie FOLBERTH
  • RAD51 inhibitors
    Patent number: 11084812
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: August 10, 2021
    Assignee: Cyteir Therapeutics, Inc.
    Inventors: Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca, Tyler Maclay
  • ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF
    Publication number: 20210230153
    Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 18, 2020
    Publication date: July 29, 2021
    Inventors: Alfredo C. Castro, Karen J. McGovern, Michael Burke
  • Cyclopamine analogs
    Patent number: 11007181
    Abstract: The invention provides derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: May 18, 2021
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Andre B. Charette, Martin R. Tremblay
  • Heterocyclic compounds and uses thereof
    Patent number: 10941162
    Abstract: Trisubstituted bicyclic heterocyclic compounds (e.g., pyridopyrimidinones) and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: March 9, 2021
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Catherine A. Evans, Martin R. Tremblay
  • AHR INHIBITORS AND USES THEREOF
    Publication number: 20210017153
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 2, 2020
    Publication date: January 21, 2021
    Inventors: Alfredo C. CASTRO, Catherine Anne EVANS
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20210000837
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Application
    Filed: March 11, 2020
    Publication date: January 7, 2021
    Inventors: Jeffery L. Kutok, David G. Winkler, Vito J. Palombella, Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • TEAD INHIBITORS AND USES THEREOF
    Publication number: 20200407327
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 31, 2020
    Inventor: Alfredo C. CASTRO
  • METHODS OF USING RAD51 INHIBITORS FOR TREATMENT OF PANCREATIC CANCER
    Publication number: 20200397760
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat pancreatic cancer.
    Type: Application
    Filed: June 22, 2020
    Publication date: December 24, 2020
    Inventors: Alfredo C. CASTRO, Melinda DAY, Tyler MACLAY, Casey Cameron MCCOMAS, Kevin MILLS, Joseph VACCA
  • Methods of use of cyclopamine analogs
    Patent number: 10821102
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: November 3, 2020
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
  • INDOLE AHR INHIBITORS AND USES THEREOF
    Publication number: 20200331917
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 22, 2020
    Inventors: Alfredo C. Castro, Catherine A. Evans