Patents by Inventor Alfredo C. Castro

Alfredo C. Castro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATIONS OF RAD51 AND PARP INHIBITORS
    Publication number: 20200306229
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula: in combination with a PARP inhibitor, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Application
    Filed: March 25, 2020
    Publication date: October 1, 2020
    Inventors: Alfredo C. CASTRO, Melinda DAY, Tyler MACLAY, Casey Cameron MCCOMAS, Kevin MILLS, Joseph VACCA
  • RAD51 INHIBITORS
    Publication number: 20200216437
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Application
    Filed: January 6, 2020
    Publication date: July 9, 2020
    Inventors: Alfredo C. CASTRO, Casey Cameron MCCOMAS, Joseph VACCA, Tyler MACLAY
  • AHR inhibitors and uses thereof
    Patent number: 10696650
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: June 30, 2020
    Assignee: Ikena Oncology, Inc.
    Inventors: Alfredo C. Castro, Catherine Anne Evans
  • Indole AHR inhibitors and uses thereof
    Patent number: 10689388
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: June 23, 2020
    Assignee: Ikena Oncology, Inc.
    Inventors: Alfredo C. Castro, Catherine Anne Evans
  • RAD51 INHIBITORS
    Publication number: 20200129484
    Abstract: This application is directed to inhibitors of RAD51, and methods for their use, such as to treat or prevent conditions involving mitochondrial defects.
    Type: Application
    Filed: July 11, 2018
    Publication date: April 30, 2020
    Inventors: Alfredo C. CASTRO, Casey Cameron MCCOMAS, Joseph VACCA
  • CYCLOPAMINE ANALOGS
    Publication number: 20200121658
    Abstract: The invention provides derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: July 24, 2019
    Publication date: April 23, 2020
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Andre B. Charette, Martin R. Tremblay
  • RAD51 inhibitors
    Patent number: 10590122
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: March 17, 2020
    Assignee: Cyteir Therapeutics, Inc.
    Inventors: Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca, Tyler Maclay
  • Indole AHR inhibitors and uses thereof
    Patent number: 10570138
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: February 25, 2020
    Assignee: Kyn Therapeutics
    Inventors: Alfredo C. Castro, Catherine Anne Evans
  • METHODS OF USE OF CYCLOPAMINE ANALOGS
    Publication number: 20200022962
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: April 26, 2019
    Publication date: January 23, 2020
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20190367521
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Application
    Filed: May 20, 2019
    Publication date: December 5, 2019
    Inventors: Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20190330240
    Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Application
    Filed: March 1, 2019
    Publication date: October 31, 2019
    Inventors: Alfredo C. Castro, Catherine A. Evans, Martin R. Tremblay
  • Cyclopamine analogs
    Patent number: 10406139
    Abstract: The invention provides derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: September 10, 2019
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Andre B. Charette, Martin R. Tremblay
  • RAD51 inhibitors
    Patent number: 10336746
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: July 2, 2019
    Assignee: Cyteir Therapeutics, Inc.
    Inventors: Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca, Tyler Maclay
  • RAD51 INHIBITORS
    Publication number: 20190194182
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Application
    Filed: December 31, 2018
    Publication date: June 27, 2019
    Inventors: Alfredo C. CASTRO, Casey Cameron MCCOMAS, Joseph VACCA, Tyler MACLAY
  • Heterocyclic compounds and uses thereof
    Patent number: 10329299
    Abstract: Provided herein are compounds of Formula (I?) or (A?), pharmaceutical compositions comprising the compounds, and methods of use thereof. The compounds provided herein modulate kinase activity, including PI3 kinase activity, and are useful for treating diseases and conditions associated with kinase activity, including PI3 kinase activity.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: June 25, 2019
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
  • Methods of use of cyclopamine analogs
    Patent number: 10314827
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: June 11, 2019
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
  • Heterocyclic compounds and uses thereof
    Patent number: 10253047
    Abstract: Trisubstituted bicyclic heterocyclic compounds (e.g., chromenones and quinolines) and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: April 9, 2019
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Catherine A. Evans, Martin R. Tremblay
  • RAD51 Inhibitors
    Publication number: 20190077799
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Inventors: Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca, Tyler Maclay
  • AHR INHIBITORS AND USES THEREOF
    Publication number: 20190055218
    Abstract: The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 21, 2019
    Inventors: Alfredo C. Castro, Catherine Anne Evans
  • CYCLOPAMINE ANALOGS
    Publication number: 20190000816
    Abstract: The invention provides derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: March 27, 2018
    Publication date: January 3, 2019
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Andre B. Charette, Martin R. Tremblay