Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Techniques for performing fine-scale movement tracking of underwater objects are described. A computing device or system may receive timestamps corresponding to acoustic signals detected using an underwater acoustic receiver. The device or system may select a period of a known acoustic transmitter, and generate raw image data plotting the timestamps as graphical elements with respect to a first axis corresponding to linear time, and a second axis having a magnitude corresponding to the selected period. A first machine learning (ML) model may process the raw image data to generate segmented image data include a subset of the graphical elements determined to correspond to the selected period. A portion of the segmented image data, including the graphical elements, may be input to a second ML model to generate image data comprising a subset of the graphical elements corresponding to the selected period.

Abstract: Photon generating substrates for light-directed oligonucleotide synthesis are disclosed. Light is generated within a solid-state stack that supports growing oligonucleotides. The light may be generated by microLEDs, a pass-through liquid crystal panel, or an LCoS system. Light passes through a transmissive layer on which growing oligonucleotides are attached. Patterning of the light is controlled by selective activation of the microLEDs or by selective control of the transparency of a liquid crystal layer. Photolabile blocking groups are selectively removed by exposure to patterned light emitted from the photon generating substrate.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Electrode controlled hybridization is used to change local pH and selectively assemble oligonucleotide complexes on the surface of a microelectrode array. The oligonucleotide complexes have sticky ends that provide locations for subsequent oligonucleotide complexes to hybridize. The order in which specific oligonucleotide complexes are joined together encodes information. Controlled activation of individual electrodes in the microelectrode array creates negative voltages that reduces a buffer solution and raises the pH in proximity to the electrodes. At higher pH levels double-stranded oligonucleotides de-hybridize. Nicks between oligonucleotide complexes and oligonucleotides anchored to the microelectrode array are closed creating covalent attachments. De-hybridized single-stranded oligonucleotides are removed leaving only the oligonucleotides connected to microelectrode array.

Abstract: In one implementation, a system for broadcasting on-duty adventure opportunities among computing devices includes an adventure management computer system to transmit (a) push notifications to selected mobile computing devices related to activated on-duty adventure opportunities and (b) local beacon signal identifiers for mobile-to-mobile beacon signal transmissions for the activated on-duty adventure opportunities, a guide mobile computing device to locally broadcast information for the on-duty adventure opportunity, and a participant mobile computing device (i) to detect the local beacon signals with the local beacon signal identifier for the on-duty adventure opportunity, (ii) to obtain the adventure information for the on-duty adventure opportunity from the adventure management computer system, and (iii) to reserve the on-duty adventure opportunity with the adventure management computer system.

Abstract: Techniques for managing outputs from persistent hybrid collaborative workspaces are disclosed. In an example, a method receives, from a client device, a request to view a history of the virtual collaborative workspace. The method obtains, from a data store, past occurrences associated with one or more virtual collaborative workspace resources within the virtual space. The virtual collaborative workspace resources can include a virtual collaborative workspace, a list of users associated with the virtual collaborative workspace, a shared document, a video stream, or textual messages. The method further transmits indications of the one or more virtual collaborative workspace resources to the client device.

Abstract: One example method includes receiving a request to join a virtual space, the request received from a user device associated with a first user; responsive to determining that the first user is a member of the virtual space, providing access to the virtual space; changing a status of the first user based on the first user accessing the virtual space; providing state information associated with a then-current state of the virtual space; and providing an indication of a conference attached to the virtual space to the first user, the conference being between two or more members of the virtual space.

Abstract: An introduced autonomous aerial vehicle can include multiple cameras for capturing images of a surrounding physical environment that are utilized for motion planning by an autonomous navigation system. In some embodiments, the cameras can be integrated into one or more rotor assemblies that house powered rotors to free up space within the body of the aerial vehicle. In an example embodiment, an aerial vehicle includes multiple upward-facing cameras and multiple downward-facing cameras with overlapping fields of view to enable stereoscopic computer vision in a plurality of directions around the aerial vehicle. Similar camera arrangements can also be implemented in fixed-wing aerial vehicles.

Abstract: In one implementation, a computer-implemented method includes receiving, at a computer system, a request for outdoor adventures that satisfy one or more criteria; accessing a centralized data repository of outdoor adventures that are provided by a plurality of different guides; identifying, by the computer system, one or more outdoor adventures based on a comparison of the one or more criteria to data associated with the outdoor adventures; generating code that includes information for the one or more outdoor adventures, the code being generated for execution or interpretation on the client computing device; and transmitting the code to the client computing device, wherein the client computing device is programmed to automatically execute or interpret the code upon receipt so as to present a graphical user interface presenting the one or more outdoor adventures and a selectable feature to reserve at least a portion of the one or more adventures.

Abstract: A processing system is disclosed for providing processing of objects that include a programmable motion device including an end effector, a perception system for recognizing any of the identity, location, and orientation of an object presented in a plurality of objects at an input location, a grasp acquisition system for acquiring the object using the end effector to permit the object to be moved from the plurality of objects to one of a plurality of destination bins, and a motion planning system for determining a changing portion of a trajectory path of the end effector from the object to a base location proximate to the input location, and

Abstract: A maintenance system is disclosed for assisting in maintaining an automated carrier system for moving objects to be processed. The maintenance system includes a plurality of automated carriers that are adapted to move on an array of discontinuous standard track sections, each said automated carrier including a carrier body that is no larger in either a length or width direction that a standard track section, and an automated maintenance carrier that is adapted to move on the array of discontinuous track sections, said automated maintenance system including a maintenance body that is larger in at least one of a length or width direction than the standard track section.

Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins is in communication with a bin conveyance system for moving selected storage bins to a storage bin processing location, a programmable motion device in communication with the bin processing location for receiving a selected storage bin from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and a plurality of destination bins in communication with the bin conveyance system for moving a selected destination bin from a destination bin processing location that is proximate the programmable motion device to the plurality of destination bins.

Abstract: A method and edge computing system configured to generate or process extended reality (XR) data. Processors in the edge computing system receive, process, and analyze a sensory feed from an optical device to generate analysis results that include a relative position of the optical device from surrounding objects. The processors generate mapper output results (that include virtual coordinates) based on the analysis results, request and receive information (e.g., salient points of interest, etc.), and compare the generated mapper output results to the received information to identify a correlation between a feature included in the processed sensory feed and a feature included in the received information. The processors generate and send augmented information to a renderer and/or send the processed sensory feed to a cloud object recognizer for further processing.

Abstract: A storage, retrieval and processing system is disclosed for processing objects. The system includes a plurality of bins including objects to be distributed by the processing system, said plurality of bins being provided in at least a partially generally circular arrangement, a programmable motion device that includes an end effector for grasping and moving any of the objects, said programmable motion device being capable of reaching any of the objects within the plurality of bins, and a plurality of destination containers for receiving any of the objects from the plurality of bins, said plurality of destination containers being provided in a region that is generally within the at least partially generally circular arrangement of the plurality of bins.

Abstract: An electrical distribution enclosure includes an electrically insulated panel defining an access portion of the enclosure and a load portion of the enclosure; at least one electrically insulated compartment panel positioned within the access portion; and two or more compartments within the access portion, each compartment separated from an adjacent compartment by an electrically insulated compartment panel, each of the two or more compartments having a front-accessible neutral connection, at least one front-accessible phase connection and a at least rear phase connection.

Abstract: Techniques for performing fine-scale movement tracking of underwater objects are described. A computing device or system may receive timestamps corresponding to acoustic signals detected using an underwater acoustic receiver. The device or system may select a period of a known acoustic transmitter, and generate raw image data plotting the timestamps as graphical elements with respect to a first axis corresponding to linear time, and a second axis having a magnitude corresponding to the selected period. A first machine learning (ML) model may process the raw image data to generate segmented image data include a subset of the graphical elements determined to correspond to the selected period. A portion of the segmented image data, including the graphical elements, may be input to a second ML model to generate image data comprising a subset of the graphical elements corresponding to the selected period.

Abstract: Photon generating substrates for light-directed oligonucleotide synthesis are disclosed. Light is generated within a solid-state stack that supports growing oligonucleotides. The light may be generated by microLEDs, a pass-through liquid crystal panel, or an LCoS system. Light passes through a transmissive layer on which growing oligonucleotides are attached. Patterning of the light is controlled by selective activation of the microLEDs or by selective control of the transparency of a liquid crystal layer. Photolabile blocking groups are selectively removed by exposure to patterned light emitted from the photon generating substrate.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.