Abstract: Electrode controlled hybridization is used to change local pH and selectively assemble oligonucleotide complexes on the surface of a microelectrode array. The oligonucleotide complexes have sticky ends that provide locations for subsequent oligonucleotide complexes to hybridize. The order in which specific oligonucleotide complexes are joined together encodes information. Controlled activation of individual electrodes in the microelectrode array creates negative voltages that reduces a buffer solution and raises the pH in proximity to the electrodes. At higher pH levels double-stranded oligonucleotides de-hybridize. Nicks between oligonucleotide complexes and oligonucleotides anchored to the microelectrode array are closed creating covalent attachments. De-hybridized single-stranded oligonucleotides are removed leaving only the oligonucleotides connected to microelectrode array.

Abstract: Photon generating substrates for light-directed oligonucleotide synthesis are disclosed. Light is generated within a solid-state stack that supports growing oligonucleotides. The light may be generated by microLEDs, a pass-through liquid crystal panel, or an LCoS system. Light passes through a transmissive layer on which growing oligonucleotides are attached. Patterning of the light is controlled by selective activation of the microLEDs or by selective control of the transparency of a liquid crystal layer. Photolabile blocking groups are selectively removed by exposure to patterned light emitted from the photon generating substrate.

Abstract: Electrode controlled hybridization is used to change local pH and selectively assemble oligonucleotide complexes on the surface of a microelectrode array. The oligonucleotide complexes have sticky ends that provide locations for subsequent oligonucleotide complexes to hybridize. The order in which specific oligonucleotide complexes are joined together encodes information. Controlled activation of individual electrodes in the microelectrode array creates negative voltages that reduces a buffer solution and raises the pH in proximity to the electrodes. At higher pH levels double-stranded oligonucleotides de-hybridize. Nicks between oligonucleotide complexes and oligonucleotides anchored to the microelectrode array are closed creating covalent attachments. De-hybridized single-stranded oligonucleotides are removed leaving only the oligonucleotides connected to microelectrode array.

Abstract: Photon generating substrates for light-directed oligonucleotide synthesis are disclosed. Light is generated within a solid-state stack that supports growing oligonucleotides. The light may be generated by microLEDs, a pass-through liquid crystal panel, or an LCoS system. Light passes through a transmissive layer on which growing oligonucleotides are attached. Patterning of the light is controlled by selective activation of the microLEDs or by selective control of the transparency of a liquid crystal layer. Photolabile blocking groups are selectively removed by exposure to patterned light emitted from the photon generating substrate.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: A computer-implemented system, platform, computer program product, and/or method for reducing data processing that includes identifying data properties used to generate features used as input to data analytic models; associating the data properties used to generate the features to corresponding features; determining whether an incoming data record is a previously processed data record; determining, in response to an incoming data record being a previously processed data record, whether the incoming data record matches the previously processed data record; identifying data properties in the incoming data record that have changed; determining features associated with the data properties in the incoming data record that have changed; and generating the features associated with the data properties in the incoming data record that have changed.

Abstract: Techniques are described herein for optimizing the presentation of content through obtaining viewership metrics, generating multiple renditions of presentations of content, and selecting optimized renditions of content. One aspect includes associating a request for viewership metrics with a presentation of content, publishing the presentation of content, and receiving information of the viewership metrics associated with the presentation. Another aspect includes copying a presentation of a content item, creating a second presentation of the content item for publishing over one or more channels, and linking the presentation of the content item to the second presentation of the content item, such that a change to one propagates to the other of the presentation of the content item or the second presentation of the content item. In yet another aspect, a content rendition may be selected for presentation based on performance of the rendition out of multiple renditions in an auction.

Abstract: A fountain apparatus may include a wall insert that can be threadably attached to a water inlet port in the wall of a pool. The wall insert may split water flow into two streams, one that passes through a jet nozzle ball and into the pool, and the other that flows into a reservoir that supplies water to a stream nozzle tip to form a water fountain. A water insert reservoir cap may be releasably engageable with the wall insert and include two fluid passageways, one corresponding to the flow path to the jet nozzle ball and the other corresponding to the reservoir and the flow path to the stream nozzle tip. A reservoir locking cap may be used to secure the wall insert reservoir cap to the wall insert. A jet nozzle cap may be used to secure the jet nozzle ball to the reservoir locking cap.

Abstract: The melting temperature of double-stranded polynucleotides is used to create temperature-sensitive tags for tracking the exposure of food items to high temperatures. Once a food item is exposed to a temperature that exceeds the melting temperature of the double-stranded polynucleotides, the two strands melt and then reanneal in a different conformation. This change in conformation can be detected by fluorophores attached to one of the polynucleotide strands. The double-stranded polynucleotides may be applied directly to food items as an edible tag. Alternatively, a tag that includes a substrate with bound polynucleotides may be attached like a sticker to the food items. This provides an economical and small device for determining if individual food items were exposed to temperatures that could negatively affect quality or safety.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: Content is organized for brands by selecting a plurality of brand templates. After each selection, a set of properties is generated by applying a portion of settings of the respective brand template, with the remaining settings being overridden with settings for a channel communicating one of a plurality of presentations to a node of a network involved in the communication. The plurality of presentations may include different renditions of the same content. The properties may include sections configured for different focus areas and/or types of content associated with at tags to enable brand-level-targeting. Filters may be identified in the properties. Based on each of the identifications, a property from among the generated sets of properties may be selected based on comparisons with the associated tags.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: Examples are disclosed that relate to using natural language processing (NLP) to determine a recipe for a chemical synthesis described in a text to create a life cycle inventory (LCI). One example provides a method comprising receiving an input of a text from a publication comprising a description of a chemical product, and analyzing the text using NLP to determine a recipe for the chemical synthesis, the recipe comprising and action and action metadata, the action metadata comprising a reactant. The method further discloses obtaining LCI information for the reactant, determining an energy utilized for the action, and creating an estimate of an environmental impact for the product.

Abstract: Recycling information is associated with objects through the use of molecular tags. The recycling information may describe the type of material that the object is made from as well as provide instructions for recycling. The molecular tags may be polynucleotides or other types of molecules including inorganic molecules. The molecular tags may be embedded within the object or attached to the surface of the object. At the end of the object's life, the molecular tags are read and the recycling information is used to appropriately recycle the object.

Abstract: The disclosure provides an aspiration syringe device and methods for use of such an aspiration syringe device. The aspiration syringe device includes an elongated housing, a plunger configured for axial sliding within the housing and being occludably received in the housing, a compression spring configured to urge the plunger away from the housing, and a retention mechanism configured to fixedly engage with the plunger so as to retain the plunger in position relative to the housing with the compression spring in an at least partially compressed state. The aspiration syringe device can be used in conjunction with another apparatus designed to penetrate a patient's body to access a distressed pleural space for the removal of air or fluid therefrom by allowing the air or fluid to flow in one direction from inside the body to outside the body.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: A portable system for managing the temperature of a patient during transport includes a heater/cooler configured to be in fluid communication with a heat transfer catheter or a heat transfer surface pad; a pump for circulating heat exchange fluid; an alternating current power supply; and a processor configured to indicate if the alternating current power supply connection to the source of alternating current is interrupted. A rechargeable battery may be configured to provide power to the system when the alternating power supply is not connected to a source of alternating current. If the system is powered on and the connection to the alternating current source is interrupted, the system may automatically switch to receiving power from the rechargeable battery. The processor may alert an operator of the interruption of the connection to the alternating current source and indicate to the operator the amount of energy remaining in the battery.

Abstract: Systems, methods, and devices are described herein for placing secondary content into a break of unknown duration in a stream of primary content. In one aspect, the described techniques may include streaming a segment of primary content, for example, by a reduce capability client device, such as a mobile device or tablet. The device may receive information indicative of a break in the streaming of the primary content. The device may play secondary content based on receiving the information indicative of the break. The device may determine when a next segment of the primary content is available, and begin streaming the next segment of the primary content upon detecting that the second segment of the primary content is available.

Abstract: A computing system is provided. The computing system comprises a processor, and memory comprising instructions executable by the processor to receive a chemical structure input, obtain retrosynthetic step data based on the chemical structure input, determine a chemical structure of a primary chemical in the retrosynthetic step data, the primary chemical being a chemical used as a starting material in a retrosynthetic step, when the structure of the primary chemical is not available in a life-cycle inventory (LCI), input the primary chemical into a trained proxy chemical selection model to select a proxy chemical for which an LCI is available, and obtain proxy chemical LCI data to include in an estimated LCI for a life cycle assessment (LCA).

Abstract: Polynucleotides used for encoding information are synthesized with universal base analogs that participate in pi-stacking interactions but do not form Watson-Crick hydrogen bonds with other bases. The universal base analogs may have pyrrole-based bases such as 5-nitroindole (5NI). Inclusion of the universal base analogs in the polynucleotides prevents polymerase-based amplification such as PCR. However, the non-amplifiable polynucleotides are able to hybridize to complementary strands and the sequences may be read by nanopore sequencing. The polynucleotides may be used as molecular taggants to label items for the prevention of forgery. The ability of polynucleotides collected from an item to hybridize with known sequences can be used to establish authenticity of an item. Alternatively, the polynucleotides may be used to encode digital data in a read-only molecule that cannot be readily copied.