Abstract: Anchor devices and methods used to secure a prosthetic valve to a native valve annulus are described. The anchor device can be a separate expandable element from the prosthetic valve that is first advanced to the annulus and deployed, after which an expandable prosthetic valve is advanced to within the annulus and deployed. The combination of the two elements can apply a clamping force to the valve leaflets which holds the prosthetic valve in place. The anchor device can have a lower or ventricular portion and an upper or atrial portion. The anchor device can include one or more leaflet clamping portions. One, two, or more upstanding vertical posts between the clamping portions can extend upward at the valve commissures and support the upper portion, which can include one or more structures for leak prevention.

Abstract: Methods, apparatus, systems and articles of manufacture to provide power to devices are disclosed. An example apparatus includes a display and an instruction presenter. The presenter is to generate a notification on the display. The notification indicates that delivery of power to the user device will be enabled in exchange for paying attention to the display during a media presentation. The apparatus also includes a detector to determine that a person associated with the user device is paying attention to the display. The charging station is to transmit power to the user device in response to the detector determining that the person is paying attention to the display.

Abstract: A quantum device includes a syndrome measurement circuit that implements an correction code using a plurality of Majorana qubit islands. The syndrome measurement circuit is adapted to effect a syndrome measurement by performing a sequence of measurement-only operations, where each one of the measurement-only operations involves at most two of the Majorana qubit islands.

Abstract: Various systems and methods for implementing adaptive synching are provided herein. A synchronization system comprises a processor; and a memory including instructions, which when executed by the processor, cause the processor to implement: a file synchronization controller to receive an indication from a client device that the client device wants to synchronize files with a file server; a policy manager to: obtain a server-side policy associated with the file server; and determine whether the file server is in a state compliant with the server-side policy; wherein the file synchronization controller is to initiate synchronization between the client device and the file server when the file server is in the state compliant with the server-side policy.

Abstract: The disclosure provides a device for developing organized tissue strips, such as cardiac tissue strips, for high-throughput assays of functional performance and the methods involved in fabricating, assembling, implementing, utilizing and analyzing data from such assays. The disclosure further provides systems for constructing such devices, systems comprising those devices comprising cells and extracellular matrix material for developing organized tissue strips or comprising the devices and organized tissue strips. The disclosure further provides methods for assaying a property of a tissue strip, such as contractile force.

Abstract: Anchor devices and methods can be used to secure a prosthetic valve to a native valve annulus. The anchor device can be a separate expandable element from the prosthetic valve that is first advanced to the annulus and deployed, after which an expandable prosthetic valve is advanced to within the annulus and deployed. The combination of the two elements can apply a clamping force to the valve leaflets which holds the prosthetic valve in place. The anchor device can have a lower or ventricular portion and an upper or atrial portion. The anchor device can include one or more leaflet clamping portions. One, two, or more upstanding vertical posts between the clamping portions can extend upward at the valve commissures and support the upper portion, which can include one or more structures for leak prevention.

Abstract: Embodiments of this invention are directed to substituted polyaniline nanofibers and methods of synthesizing and using the same. The invention is also directed to polyaniline derivatives that can be synthesized without the need for templates or functional dopants by using an initiator as part of a reaction mixture.

Abstract: Various embodiments provide techniques for generating a style profile in which items are recognized in image data, analyzed for their attributes, and categorized based on those attributes. In various embodiments, computer vision techniques can be used to analyze the image data and subsequent image data to update the generated style profiles. The style profiles may be associated with a person, event, or the like and provide users with items having similar characteristics or attributes, which may be available for purchase in an electronic marketplace. The style profiles may be updated by analyzing user interaction with the provided items and by receiving additional image data. Additionally, recommendations may be provided based on search queries that identify certain events or style profiles.

Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.

Abstract: Disclosed in some examples are systems, methods, and machine readable mediums which provide for a data management microservice which registers and manages data across multiple microservices to reduce data fragmentation and to ensure correct disposal of this data upon request. In some examples, the data management microservice may include an erasure service which ensures that all data corresponding to a data characteristic is deleted.

Abstract: A delivery catheter is in various embodiments configured to deliver an anchoring device to a native valve annulus of a patient's heart, where the anchoring device can better secure a prosthesis at the native annulus. The delivery catheter can includes a distal section that includes one or more spines or is laser cut to assume a particular shape for better facilitating delivery of the anchoring device at the implant site and can include a flexible tube, a first pull wire, and a second pull wire. The flexible tube can comprise a bore extending between the first end and the second end sized for passing the anchoring device therethrough. The distal portion can comprise a first flexing section and a second flexing section. Actuation of the first pull wire and the second pull wire can cause the flexible tube to move from a first configuration to a second configuration.

Abstract: Devices for occluding an aneurysm are provided. In particular, the device include an upper member that sits against the dome of the aneurysm, a lower member that sits in the neck of the aneurysm, and a means of adjusting the overall dimensions of the device. Also provided are methods of making and using these devices.

Abstract: A computing system is provided, including a processor configured to identify a plurality of measurement sequences that implement a logic gate. Each measurement sequence may include a plurality of measurements of a quantum state of a topological quantum computing device. The processor may be further configured to determine a respective estimated total resource cost of each measurement sequence of the plurality of measurement sequences. The processor may be further configured to determine a first measurement sequence that has a lowest estimated total resource cost of the plurality of measurement sequences. The topological quantum computing device may be configured to implement the logic gate by applying the first measurement sequence to the quantum state.

Abstract: In one representative embodiment, a steerable catheter device comprises a shaft comprising a proximal portion and a distal portion, and first and second pull wires having respective proximal portions and respective distal portions. The proximal portions of the first and second pull wires extend through the proximal portion of the shaft in close proximity to each other. The distal portions of the first and second pull wires extend through the distal portion of the shaft in close proximity to each other over a first distance defining a primary flexing section, diverge away from each other over a second distance, and then extend parallel to each other at angularly spaced locations over a third distance defining a secondary flexing section.

Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.

Abstract: A two-stage or two-tier system and method for rapid screening of compounds for inotropic effects is disclosed. The system comprises, in a first tier, an engineered cardiac tissue strip (CTS) comprising cardiomyocytes, such as human ventricular cardiomyocytes, embedded in a biocompatible gel wherein the gel comprises at least two biocompatible structural supports such as polydimethylsiloxane posts for elevating the gel. The system further comprises, in a second tier, an apparatus comprising at least one organoid module comprising at least one organoid cartridge, wherein each organoid cartridge comprises an organoid, and a minor arrangement. The system further comprises at least one detection device, such as a high-speed camera, for detecting deflection of the CTS gel in the first tier of the system and/or for detecting tissue or organoid behavior in the organoid cartridge or cartridges of the second tier of the system.

Abstract: In an exemplary method, a first layer is formed on a substrate. First overlay marks are formed in a first zone of the first layer. A non-transparent layer is formed on top of the first layer. At least a portion of the non-transparent layer is removed from an area above the first zone of the first layer. This provides optical access to the first overlay marks. A second layer is formed on top of the non-transparent layer. Second overlay marks are formed in a second zone of the second layer. Position information is obtained from each of the first overlay marks and the second overlay marks.

Abstract: Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment. The docking devices can have an end portion with a central axis. The retrieval suture can be connected to the end portion such that a line of force applied by applying tension to the retrieval suture is substantially aligned with the central axis.

Abstract: Various systems and methods for implementing adaptive synching are provided herein. A synchronization system comprises a processor; and a memory including instructions, which when executed by the processor, cause the processor to implement: a file synchronization controller to receive an indication from a client device that the client device wants to synchronize files with a file server; a policy manager to: obtain a server-side policy associated with the file server; and determine whether the file server is in a state compliant with the server-side policy; wherein the file synchronization controller is to initiate synchronization between the client device and the file server when the file server is in the state compliant with the server-side policy.

Abstract: In one representative embodiment, a steerable catheter device comprises a shaft comprising a proximal portion, a distal portion, and a pull-wire lumen that extends at least partially through the proximal and distal portions. A pull wire extends through the pull-wire lumen and has a proximal end portion and a distal end portion, wherein the distal end portion of pull wire is fixed to the distal end portion of the shaft. An adjustment mechanism is operatively connected to the proximal end portion of the pull wire and configured to increase and decrease tension in the pull wire to adjust the curvature of the distal portion of the shaft. An axially non-compressible pull-wire sleeve extends co-axially through the pull-wire lumen and over the pull wire.