Abstract: An input device, such as a stylus, can be operated to determine one or more conditions and select an appropriate operating mode. For example, a stylus can be attached to a host device when not in active use by a user. Attachment can be securely and releasably achieved with magnetic coupling. In such a configuration, the stylus can detect the attachment based on the presence and modification of magnetic fields. Based on such detection, the stylus can select an operating mode that allows power to be conserved when it is determined that certain components of the stylus need not be actively operated.

Abstract: A pin tumbler lock apparatus includes a shell and a gate housed within the shell. The gate consists of a cylindrical case with multiple bores. A core, positioned within the gate, features a keyway and additional bores aligning with the gate's bores to form pin chambers when locked. Key pins within these chambers are magnetically responsive and vary in height within a defined range. Each key pin comprises a body and an oversized top element. Channels in the gate correspond to the pin chambers, allowing the top element of each key pin to move within its respective channel when a key is inserted into the keyway and the core is rotated relative to the gate.

Abstract: A fuel conditioning system includes a heater for selectively adjusting an operating temperature of the fuel and a controller communicatively coupled to the heater. The controller configured to determine a dew point temperature of the fuel and maintain the operating temperature of the fuel at least at the determined dew point temperature of the fuel.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

Abstract: The present invention relates to purified and concentrated human milk oligosaccharide compositions and methods of making and using the same.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible conduit having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the conduit distal portion. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: The present application relates to systems, methods, and apparatus for facilitating the testing of a payload. An exemplary apparatus may include a fluid inlet port configured to receive fluid from a thermal subsystem of the payload. The apparatus may also include an actuating device configure to supply the fluid to a heat exchanger. A valve may be configured to receive the fluid from the heat exchanger and separate the fluid into a first fluid line and a second fluid line. A first fluid outlet port may be configured to supply the fluid to the thermal subsystem of the payload and a second fluid outlet port may be configured to supply the fluid to the thermal subsystem of payload.

Abstract: An endovascular system includes a delivery device operable to advance and/or retract a tubular implant disposed in the lumen of a catheter. The delivery device comprises a delivery wire, a set of stoppers comprising a distal stopper and a proximal stopper fixedly attached to the delivery wire, and a coupler disposed between the distal stopper and the proximal stopper of the set. The coupler is configured to contact and apply an outwardly radial force to a distal end portion of the tubular implant in the lumen of the catheter to grip the tubular implant in the lumen of the catheter. The proximal stopper of the set is configured to engage the coupler when the delivery wire is advanced to apply a translating force in a distal direction to the coupler thereby generating a pulling force in the distal direction on a portion of the tubular implant proximal of the distal end portion of the tubular implant.

Abstract: Observed driveline mean and variance data are used for determining the variance of a trajectory of tracked objects for use by a host vehicle. A map of a portion of a vehicle transportation network are determined, wherein the map is comprised of observed driveline mean and variance data for one or more map points. At least one trajectory of a tracked object is predicted, wherein a trajectory includes a series of location each corresponding to a respective predicted position of the tracked object at a future time. A map-based variance is generated for the location of the trajectory using a smoothed curvature of the trajectory within the map. A control system of the vehicle operates the vehicle using the map-based variance as input.

Abstract: A product includes a mixture for converting a polyurethane where the mixture includes a functional alcohol and a catalyst. A method of converting polyurethane includes forming a mixture at an ambient temperature where the mixture includes a polyurethane, a functional alcohol, and a catalyst. The method further includes collecting a product from the mixture after a duration of time. The product includes a diallyl urethane monomer and a multi-functional alcohol.

Abstract: A medical device, configured to perform an endovascular therapy, e.g., thrombectomy, can comprise an elongate manipulation member having a first connection member proximate a distal end of the elongate manipulation member, and an intervention member having a second connection member proximate a proximal end of the intervention member. The second connection member can be connected to the first connection member such that the first connection member can rotate relative to the second connection member.

Abstract: An approach is disclosed herein a sequence generation ecosystem using machine learning. The approach disclosed herein is a new approach to sequence generation in the context of validation that relies on machine learning to explore and identify ways to achieve different states. In particular, the approach divides the valid operations into different respective actions and action sequences. These actions are selected by machine learning models as they are being trained using online inference reinforcement learning. This online inference also is likely to result in the discovery of new states. Each state that has been identified is then used as a target to train a respective machine learning model. As part of this process a representation of all the states and actions or sequences of actions executed to reach those states is created. This representation, the respective machine learning models, or a combination thereof can then be used to generate different test sequences.

Abstract: A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach.

Abstract: A healthcare delivery system, a wearable computing device, and a method are disclosed. The method includes capturing, by the wearable computing device worn by a medical practitioner, medical multimedia data of a patient during a medical procedure. The method further includes displaying one or more selectable options associated with the medical multimedia data on a display screen of the wearable computing device to the medical practitioner. Further, the method includes receiving a selection of a selectable option from among the one or more selectable options. Thereafter, at least one action is performed on the medical multimedia data based on the selection of the selectable option. An example of the at least one action includes sharing at least a part of the medical multimedia data with a third party device.

Abstract: A future financial metric is predicted using one or more computer processors. A financial metric prediction request is received from a user. Based on the financial metric prediction request, financial data is obtained. The financial data is inputted to one or more trained machine learning models. Using the one or more trained machine learning models, one or more preliminary predictions of the future financial metric are outputted. The one or more preliminary predictions of the future financial metric are inputted to a regression model. Using the regression model, a prediction of the future financial metric is generated.

Abstract: A hair treatment composition in a anionic, nonionic or amphoteric system includes water and a novel association of polysaccharide, such as inulin, and a film-forming polymer, such as polysilicone-29. The composition may include one or more additional components selected from polymers such as anionic polymers and nonionic polymers, amphoteric surfactants, or fatty compounds, embodied to deliver one or more of smoothing, straightening and curling/curl defining style features to achieve a particular straight or curly style with frizz control, softness and manageability.

Abstract: Configurations are described for assisting execution of a percutaneous procedure while protecting the vascular pathway to the target treatment area. One example is directed to an embolic protection system for deploying a device to a distal location across a diseased vessel, the embolic protection system which may include an expandable introducer, an embolic protection device, and a loading sleeve.

Abstract: The present invention relates to a bonding resin useful for example in the manufacture of laminates, mineral wool insulation and wood products such as plywood, oriented strandboard (OSB), laminated veneer lumber (LVL), medium density fiber-boards (MDF), high density fiberboards (HDF), parquet flooring, curved plywood, veneered particleboards, veneered MDF or particle boards. The bonding resin is also useful for example in composites, molding compounds and foundry applications. The invention also relates to a method for preparing the bonding resin. The bonding resin comprises an aqueous solution comprising lignin and/or tannin and ammonia and/or an organic base and hydroxymethylfurfural, furfural, furfuryl alcohol, acetoxy methyl furfural or an oligomer of hydroxy methylfurfural or a combination thereof and optionally one or more crosslinker and optionally one or more additives.

Abstract: Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of GYSI RNA in a cell or subject, and in certain instances reducing the amount of GYSI protein in a cell or subject. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a glycogen storage disease. Such glycogen storage diseases include Lafora disease, adult polyglucosan body disease (APBD), Andersen's disease, and Pompe disease.