Abstract: Methods of determining a disease score of a patient diagnosed with lysosomal storage disease (LSD) are described. The disease score includes one or more of the following: (i) one or more biofluid biomarkers; (ii) one or more neurophysiological measurements; and (iii) one or more neurobehavior measurement. Also described method of treating LSD including determining the disease score and administering to the patient a therapy. The therapy includes one or more of the following: (i) enzyme replacement therapy, (ii) gene therapy; and (iii) a small molecule.

Abstract: A display hanger assembly is used to hang and display a variety of consumer products in a retail setting. The assembly includes a hook element for hanging from a display rack peg and an integrally molded consumer product attachment assembly. The attachment assembly includes product support member and hook element attachment member. The attachment member includes a first interconnecting portion and a second interconnecting portion which are detachably connected for securement to the hook element.

Abstract: A computer system is operable to provide a design interface for enabling creation of a graphic design for a production environment. The design interface can utilize a variable data structure to implement themes, including changes to themes.

Abstract: A method of programming a curved path for a welding robot includes recording input of a first arc segment endpoint, a first intermediate point, and a second arc segment endpoint along the curved path. The first intermediate point is located between the first and second arc segment endpoints. The curved path is determined from the first and second arc segment endpoints and the first intermediate point. Input of a third arc segment endpoint is recorded. A distance of the third arc segment endpoint to the curved path is determined and compared to a threshold distance. A second intermediate point along the curved path between the second and third arc segment endpoints is automatically interpolated when the distance is less than the threshold distance. The first, second and third arc segment endpoints, and the first and second intermediate points are communicated to a robot controller to program movements of the welding robot.

Abstract: A device may include a processor configured to receive, by a system process and from an application process, a visibility preference for an object type and segment one or more physical objects associated with the object type from an image of a physical environment. The processor is also configured to determine, by the system process, whether to display the one or more segmented physical objects based at least in part on the visibility preference. In response to a determination display the one or more segmented physical objects, the processor is configured to display at least a portion of the image corresponding to the one or more segmented physical objects. In response to a determination not to display the one or more segmented physical objects, the processor is configured to forgo displaying that at least a portion of the image corresponding to the one or more segmented physical objects.

Abstract: Aspects disclosed include hardware micro-fused memory (e.g., load and store) operations. In one aspect, a hardware micro-fused memory operation is a single atomic memory operation performed using a plurality of data register operands, for example a load pair or store pair operation. The load pair or store pair operation is treated as two separate operations for purposes of renaming, but is scheduled as a single micro-operation having two data register operands. The load or store pair operation is then performed atomically.

Abstract: Systems and methods for visualizing and manipulating graph databases in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a graph database manipulation device including a processor and a memory configured to store a graph database manipulation application, wherein the graph database manipulation application configures the processor to obtain a graph database, wherein the graph database includes a set of nodes and a set of edges, identify a region of interest within a graph described by the graph database, construct a feature space from the region of interest, and extract explanatory variables from the feature space.

Abstract: An apparatus includes a body, and anchoring feature, and a guide feature. The body is sized and configured to be positioned on an eye of a patient. The anchoring feature is configured to secure the body to the eye of the patient. The guide feature is configured to guide a cannula into a scleral incision formed in the eye of the patient along a path that is substantially tangential relative to the eye of the patient. The guide feature is sized and configured to allow the cannula to pivot laterally through a range of angular motion at the scleral incision.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a transmitting device may generate a waveform having an original amplitude. The transmitting device may reduce a peak portion of the original amplitude that is above a mirror level according to a reduction function that is based at least in part on a difference function associated with a difference between the mirror level and the peak portion, to obtain a reduced peak amplitude for the waveform. The transmitting device may transmit the waveform with the reduced peak amplitude. Numerous other aspects are described.

Abstract: The present disclosure relates to articles (and the manufacture thereof) that use electrical energy to heat a material to form an inhalable substance, the articles being sufficiently compact to be considered “hand-held” devices. In certain embodiments, the articles can particularly be characterized as smoking articles. The smoking article can be adapted to detect the status of a cartridge portion of the smoking article. The smoking article includes a control body portion having a control body engagement end, wherein the control body portion houses a control component and a power source therein. The article further includes a cartridge body portion that has a cartridge body engagement end configured to removably engage the control body engagement end of the control body portion. The cartridge body portion houses a consumable arrangement and a heating connection operably engaged therewith comprising at least one heating element and a fusible link.

Abstract: An embodiment includes a robotic welding system for generating a motion program, having a programmable robot controller of a robot having a computer processor and a computer memory. The programmable robot controller is configured to digitally record, in the computer memory, a plurality of spatial points along an operator path in a 3D space taken by a calibrated tool center point (TCP) of the robot as an operator manually moves a robot arm of the robot along the operator path from a start point to a destination point within the 3D space. The programmable robot controller is also configured to identify and eliminate extraneous spatial points from the plurality of spatial points as digitally recorded, leaving a subset of the plurality of spatial points as digitally recorded, where the extraneous spatial points are a result of extraneous movements of the robot arm by the operator.

Abstract: Aspects of the subject disclosure may include, for example, implementing a first stage including a first number of phase rotators in parallel generating respective clock phases offset by a fixed amount; a second stage including a second number of phase rotators receiving outputs from the first number of phase rotators of the first stage, the second stage outputting a first weighted sum of respective clock phases generated by the second number of phase rotators. The subject disclosure further includes the second number of phase rotators being less than the first number of phase rotators, and a total number of bits dedicated to phase selection being split across the first stage and the second stage. Other embodiments are disclosed.

Abstract: Systems and methods for delivering packages using mobile robots. In some examples, a system includes a central controller configured for fulfilling package delivery orders. The system includes package delivery robots. Each package delivery robot is configured for navigating to a location of a package in the warehouse and loading the package onto the package delivery robot. Each package delivery robot is configured for navigating to a package destination by travelling on a path through one or more enclosed passageways and unloading the package at the package destination.

Abstract: An illuminating drywall sponge device provides a drywall sanding/scraping tool having tapered cavities that securely retain an illumination mechanism, such that the work surface being sanded is illuminated during sanding operations; and a marking mechanism for marking the illuminated work surface. The sponge light device provides a housing through which the sanding function is primarily performed. The housing has a block or rectangular shape, and walls with an abrasive material. The housing also has multiple tapered cavities formed at the walls of the housing, oriented coplanar with the surface being sanded. An illumination mechanism fits into the cavity. The illumination mechanism orients in the cavity to throw light outwardly from the edge of the housing. A grommet fits into the outer region of the cavities to help stabilize and fasten the illumination mechanism in the cavities. A retractable marking mechanism may also insert into the cavity.

Abstract: Provided herein are methods of treating non-hemorrhagic closed head injury (NHCHI) with 3,3?-diindolylmethane or an analog thereof. In one embodiment, NHCHI covers Traumatic Brain Injuries (TBIs) including mild to severe concussion, blast injury due to proximity to explosions, cerebral contusion, coup-contrecoup injury, DAI, Second Impact Syndrome, or CHI associated with deceleration injury.

Abstract: A computer-implemented method when executed by data processing hardware of a legged robot causes the data processing hardware to perform operations including receiving sensor data corresponding to an area including at least a portion of a docking station. The operations include determining an estimated pose for the docking station based on an initial pose of the legged robot relative to the docking station. The operations include identifying one or more docking station features from the received sensor data. The operations include matching the one or more identified docking station features to one or more known docking station features. The operations include adjusting the estimated pose for the docking station to a corrected pose for the docking station based on an orientation of the one or more identified docking station features that match the one or more known docking station features.

Abstract: A hearing device sizer tool in accordance with at least one of the present inventions includes a shaft defining a medial end and a lateral end, and an in-the-canal (ITC) hearing device seal associated with the medial end of the shaft. A hearing device sizer tool system in accordance with at least one of the present inventions includes a plurality of hearing device sizer tools with differently sized ITC hearing device seals.

Abstract: The present invention relates to the use of a porous polymer etched ion-track membrane as separator for batteries comprising a positive electrode, a negative electrode and a liquid electrolyte comprising at least one salt of a cationic ion in solution in a solvent, and to batteries comprising such a membrane as porous separator.