Abstract: A scanning device including a scanning platform, a bar, a carriage, a contact image sensor, a positioning member and an elastic member is provided. The bar disposed below the scanning platform is parallel to the first edge. The carriage has a bottom surface and a top surface. The bottom surface has a receiving part for receiving the bar. The top surface faces the scanning platform. The carriage is slideably moved below the scanning platform along the bar. The contact image sensor disposed on the top surface is for scanning a document. The positioning member which is slideably or rotatably disposed on the bottom surface is for pressing against the bar. The elastic member is connected to the carriage and the positioning member and provides an elastic force to the positioning member. The elastic force transmitted to the bar enables the contact image sensor to press the scanning platform tightly.

Abstract: There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredients, rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates rapidly with saliva in the buccal cavity forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing one or more actives) with a taste-masking membrane applied by a modified solvent coacervation process comprising a water-insoluble polymer and at least one gastrosoluble inorganic or organic pore-former, exhibit a pleasant taste when placed in the oral cavity and provide rapid, substantially-complete release of the dose on entry into the stomach.

Abstract: There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing the active), coated with a taste-masking membrane comprising a water-insoluble polymer and one or more gastrosoluble inorganic or organic pore-formers (practically insoluble in water and saliva, but soluble in an acidic buffer), exhibit acceptable taste-masking when placed in the oral cavity and provide rapid, substantially-complete release of the dose on entry into the stomach.

Abstract: Described is the efficient synthesis of an easy to manipulate and utilize, soluble tartrate salt of a potent, reversible butyrylcholinesterase inhibitor, (?)-(3aS)-3a-methyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indol-5-yl N—4?-isopropylphenylcarbamate (“MHI tartrate”), for use in altering the enzymatic activity of butyrylcholinesterase and/or acetylcholinesterase in a subject exhibiting or predicted to exhibit cognitive disorders associated with diabetes. Subjects may be suffering from or predicted to suffer from abnormal acetylcholinesterase and/or butyrylcholinesterase activity levels or from an inability to metabolize or catabolize blood sugar normally. The method comprises administering to the subject an effective amount of MHI tartrate dispensable in discrete pharmaceutically useful dosages. MHI tartrate effectively inhibits both acetylcholinesterase and butyrylcholinesterases and additionally is highly selective for butyrylcholinesterase over acetylcholinesterase.

Abstract: An adaptive coefficient signal generator for use in an adaptive signal equalizer with fractionally-spaced feedback. The signals representing the feedback tap coefficients are generated in conjunction with a timing interpolation parameter such that the fractionally-spaced feedback circuitry dynamically emulates symbol-spaced feedback circuitry.

Abstract: An implementation of a technology, described herein, for transmitting compressed network transport-layer-protocol headers in a speedy, efficient, inferentially synchronized, and robust manner. An implementation, described herein, models the transmission of compressed headers to the congestion procedure of the network transport-layer protocol (e.g., TCP's). Doing so, the sender of the compressed headers can infer whether the receiver correctly received them. Unlike the slow direct synchronization employed by conventional schemes, this implementation of the present claimed invention inferentially synchronizes by modeling after the congestion procedure of the network transport-layer protocol. This is inherently faster than direct synchronization. Since the implementation performs well over both noiseless and noisy links, it is particularly suited to use over wireless communications channels. This abstract itself is not intended to limit the scope of this patent.

Abstract: The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.

Abstract: One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.

Abstract: The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

Abstract: A microstrip antenna for receiving an RF signal from a satellite includes a radiation element and a ground plane disposed substantially parallel to and spaced from the radiation element. A first dielectric and a second dielectric are sandwiched between the ground plane and the radiation element, in a side-by-side relationship. The first dielectric has a first relative permittivity and the second dielectric has a second relative permittivity different from the first relative permittivity. A feed line electrically connects the antenna to an amplifier. A section of the feed line is disposed between the first and second dielectrics. The antenna produces the effect of tilting a radiation beam from a higher to a lower elevation angle to achieve a higher gain at lower elevation angles.

Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract: Masks that include optical proximity correction or phase shifting regions are increasingly being used in the manufacturing process. These masks, either initially or after repair, can have “soft” defects, e.g. phase and/or transmission defects. In accordance with one feature of the invention, soft defect information can be computed from standard test images of a mask. This soft defect information can be used to generate an accurate simulated wafer image, thereby providing valuable defect impact information to a user. Knowing the impact of the soft defect can enable a user to make better decisions regarding the mask. Specifically, a user can now with confidence accept the mask for the desired lithographic process, repair the mask at certain critical locations, or reject the mask, all without exposing a wafer.

Abstract: A field emission luminescent lamp includes a bulb (40) being vacuum sealed and defining an inner surface; a lamp head mated with the bulb; an electron emitting cathode filament (20) having a conductive wire (10) and a plurality of electron emitters (12) formed thereon, the electron emitting cathode filament is positioned in the bulb; an anode layer (44) formed on the inner surface of the bulb; a phosphor layer (42) formed on the anode layer; an anode electrode (56) located at the lamp head and electrically connected with the anode layer; and a cathode electrode (54) located at the lamp head and electrically connected with the electron emitting cathode filament. The lamp may further include a gate grid (62) and a gate electrode (54). The gate grid defines a number of grid holes and surrounds the cathode filament. The gate grid is electrically connected with the gate electrode.

Abstract: The present invention describes a method and system for intelligent diagnostic relevant information processing and analysis. Information associated with a patient is processed via an image reading platform. Based on such processed information, a matrix of diagnosis decisions containing diagnostic related information is generated via a matrix of diagnosis decision platform. A diagnostic decision is made based on the diagnostic relevant information. The image reading platform and/or the matrix of diagnosis decision platform encapsulate information and toolkits to be used to manipulate the information.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Compounds of formula (I) are provided, wherein R1 and R2 are as designated in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.

Abstract: An adaptive coefficient signal generator for use in an adaptive signal equalizer with fractionally-spaced feedback. The signals representing the feedback tap coefficients are generated in conjunction with a timing interpolation parameter such that the fractionally-spaced feedback circuitry dynamically emulates symbol-spaced feedback circuitry.

Abstract: The invention is directed to immunologically privileged cells, e.g., autologous, allogeneic, and xenogeneic intermediate lobe pituitary cells, for delivering polypeptides, e.g., insulin, to a subject, and to methods of using the same.

Abstract: Techniques for monitoring frequency-dependent parameter and optical property such as optical dispersion in a modulated optical signal with sidebands based on optical vestigial sideband filtering. Monitoring implementations for both chromatic dispersion and polarization-mode dispersion are described as examples.