Abstract: The present application provides methods of treating a disease, such as Pompe disease, in a subject, comprising detecting an erythropoiesis biomarker in a sample of the subject after administration of methotrexate and a therapeutic agent to the subject, and administering further treatment with or without concurrently administering additional immune tolerance induction or immunosuppression therapy based on the level of the erythropoiesis biomarker. Further provided by the present application are methods and kits for assessing the level of immune tolerance to a therapeutic agent in a subject based on detection of an erythropoiesis biomarker after administration of methotrexate and the therapeutic agent to the subject.

Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: A delivery device for transtendinous implantation of a toggle-type suture anchor into bone is disclosed. The device includes a proximal housing having an outer tubular shaft extending distally with a lumen therethrough. An anchor delivery tube extends through the lumen of the outer tubular shaft having a proximal end affixed to the proximal housing. The anchor delivery tube includes a nub portion that is used to insert through the tendon and partly into bone to maintain registration with a bone hole into which an anchor is placed. A bone punch assembly extends through the lumen of the anchor delivery tube and the nub portion with a pointed distal end. When the bone punch is fully inserted, the pointed distal end extends a distance distal of the distal end of the nub portion.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: A video may include a capture of a scene, such as a wide-field of view capture of the scene. Context of the video may be assessed and used to suggest framing of the video. The framing of the video may be presented within a user interface. A user may select, through the user interface, the framing to be used in generating presentation of the video.

Abstract: Included in the present disclosure is a wallet comprising a plate, a first rail coupled to the plate, and a second rail coupled to the plate and spaced from the first rail. In some embodiments, the plate comprises a card receiving surface and an outer facing surface opposite to the card receiving surface, and is configured to receive at least one card. The plate may also define a first edge, a second edge, a third edge, and a fourth edge. In some embodiments, the wallet further comprises at least one tension element configured to securely couple the at least one card to the plate, the at least one tension element further configured to facilitate removal of the at least one card along at least two of the first edge, the second edge, the third edge, and the fourth edge.

Abstract: Methods and systems for secure caller identification are described herein. In one implementation, when a phone call from a caller is received, a home network may mark a caller ID as trustable in a trusted flag if the caller ID can be verified. The home network may further forward the caller ID and a replica of the flag to a next hop entity until the next hop is the callee. The network on each hop may further verify the caller ID based on a trust relationship between the network and a prior network. In another implementation, the home network of the caller may send a caller ID token (CIT) associated with the caller and send a replica of CIT to a serving network of the callee through one or more networks. The serving network may verify the replica of CIT to determine whether the caller ID is trustable.

Abstract: Mechanisms are provided for rendering virtual objects in a computer generated virtual environment. Physical environment condition data is received and transformed into UV map data structure(s), where each UV map data structure comprises entries that store one or more environment condition values mapped from the physical environment condition data to the UV map data structure. A customized shader processes the UV map data structure(s) to apply environment condition effects to a rendering of a virtual object corresponding to the customized shader. The customized shader executes on the environment condition data of the UV map data structure(s) and specifies a modification to a representation of the virtual object due to the environment condition values represented in the UV map data structure(s). Generation of the virtual object in the virtual environment is controlled based on results of processing the one or more UV map data structures by the customized shader.

Abstract: An absorbent article comprising a chassis comprising a central longitudinal axis and an absorbent core is provided. The chassis comprises a front waist region, and a landing zone and an elastic waist feature both positioned in the front waist region. The elastic waist feature comprises a first end edge that is positioned proximate to a front waist edge. The elastic waist feature is: in an overlapping relationship with a portion of the landing zone by longitudinal distance, Y; and in an overlapping relationship with a portion of the absorbent core in the front waist region by a longitudinal distance, X. The elastic waist feature has a longitudinal distance, W, between the first end edge and a second end edge. A ratio of the distance, X, to the distance, W, is at least 0.4 and a ratio of the distance, Y, to the distance, W, is at least 0.4.

Abstract: In one example in accordance with the present disclosure, an electronic device is described. An example electronic device includes a processor and memory storing executable instructions that when executed cause the processor to receive an image of a polymer melt pool captured during crystallization of the polymer melt pool. The instructions also cause the processor to measure brightness of the polymer melt pool in the captured image. The instructions further cause the processor to determine crystallization information of the polymer melt pool based on the measured brightness of the polymer melt pool.

Abstract: A method and apparatus are provided for transtendinous implantation of a toggle-type bone anchor. Measured from the top surface of the tendon, the entire bone anchor is inserted to a depth of greater than or equal to 20 mm. during a rotator cuff repair on the humeral head. The anchor is pushed by the same bone punch that formed the initial hole to assure proper depth of placement. Further, the apparatus includes a nub portion that, in use, protrudes into the bone hole formed by the bone punch and maintains registration with the bone hole when the bone punch is retracted. An angled distal end on the anchor initiates toggling during insertion into the bone and at least one proximal projecting fin prevents the anchor from backing out of the bone hole while facilitating further rotation of the anchor when a suture is pulled to complete toggling.

Abstract: Implements for cleaning and storing nail drill bits are disclosed which may comprise a body, first, second, and third pluralities of holes, a fluid compartment, a cover and a brush compartment. The cover may be associated with the fluid compartment such that when the cover is in an open configuration, cleaning and disinfectant solutions contained in reservoirs of the fluid compartment can be accessed through the first plurality of holes. A soiled nail drill bit can be cleaned by submerging the bit in the cleaning solution, brushing the bit with bristles of the brush compartment, drying the bit in the second plurality of holes, and submerging the bit in the disinfectant solution. The third plurality of holes may receive the cleaned nail drill bits so they may be used in a manicure or pedicure operation.

Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for an implant, then return to a non-expanded state after the passage of the device. The sheath includes a foldable inner member having a detached flap structure at its distal tip that facilitates expansion of the sheath lumen to increased diameters, and an elastomeric distal end that reduces push and retrieval forces therethrough. The sheath can include a hemostasis seal on its proximal end to prevent the leakage of blood out of the sheath and prevent ballooning of outer layer of the sheath.

Abstract: A method and a system for performing distance metric learning using proxies are provided. The method for performing distance metric learning assigns a proxy as an anchor to represent a class and associates the proxy with all data points in a training batch. The method allows data points to interact with each other via proxies during training. Additionally, the fine-grained data-to-data relation is actively considered, which is combined with a learnable margin parameter leading to intra-class compactness and inter-class separability.

Abstract: The disclosure is directed to an apparatus and method for recovering ethanol from a fermentation broth. The fermentation broth comprises microbial biomass, ethanol, methanol, ethyl acetate, at least one thiol, and at least one compound having 3 or more carbon atoms. The method comprises separating at least microbial biomass from the fermentation broth to generate a process stream; removing, in any order, from the process stream: ethyl acetate by reacting ethyl acetate with a base compound followed by distillation; at least one thiol by adsorption or reaction to disulfide; methanol by distillation; compounds having 3 or more carbon atoms by distillation; and recovering ethanol by distillation; wherein the distillations may be conducted in a single column or two or more columns.

Abstract: A decoding engine within an integrated-circuit (IC) component executes a first plurality of error detection/correction operations with respect to first and second pluralities of data volumes to generate a corresponding first and second pluralities of error syndrome values. Each data volume of the first plurality of data volumes includes a first data block and a first error correction code together with a respective one of a plurality of unique q-bit metadata values, and each data volume of the second plurality of data volumes includes a second data block and a second error correction code together with a respective one of the plurality of unique q-bit metadata values. Output circuitry within the decoding engine selects one of the plurality of q-bit metadata values to be an output q-bit metadata value according to error-count differentiation indicated by the first and second pluralities of error syndrome values.

Abstract: The present disclosure includes memory having a continuous channel, and methods of processing the same. A number of embodiments include forming a vertical stack having memory cells connected in series between a source select gate and a drain select gate, wherein forming the vertical stack includes forming a continuous channel for the source select gate, the memory cells, and the drain select gate, and removing a portion of the continuous channel for the drain select gate such that the continuous channel is thinner for the drain select gate than for the memory cells and the source select gate.

Abstract: An electromechanical power switch device and methods thereof. At least some of the illustrative embodiments are devices including a semiconductor substrate, at least one integrated circuit device on a front surface of the semiconductor substrate, an insulating layer on the at least one integrated circuit device, and an electromechanical power switch on the insulating layer. By way of example, the electromechanical power switch may include a source and a drain, a body region disposed between the source and the drain, and a gate including a switching metal layer. In some embodiments, the body region includes a first body portion and a second body portion spaced a distance from the first body portion and defining a body discontinuity therebetween. Additionally, in various examples, the switching metal layer may be disposed over the body discontinuity.

Abstract: A rapid, comprehensive and sensitive method for neoantigen screening from recurrent cancer mutations comprising: (A) STEP 1: selecting recurrent cancer mutations dividing into three tiers based on ranking features; (B) STEP 2: Generating a library of artificial antigen presenting cells (aAPC) co-expressing HLA types (including a list of 13 most frequent HLA class I types covering 66% of Asian population or 67% of Vietnamese population, and a list of 04 most frequent HLA class II types covering 41% Asian population or 50% of Vietnamese population) and a co-stimulatory molecule; and (C) STEP 3: Using the library of aAPC at step (B) for rapid and comprehensive screening for selecting of immunogenic peptides (neoantigens) from the off-the-shelf peptides at step (A) activate T cells via immunological assays (ELISpot or intracellular staining flow cytometry).