Abstract: Disclosed is a pharmaceutical combination comprising a glucokinase activator or a pharmaceutically acceptable salt thereof, an isotopic label thereof, a crystalline form thereof, a hydrate, a solvate, a diastereomeric or enantiomeric form thereof, and a DPP-IV inhibitor. Disclosed are a pharmaceutical composition and a fixed dose of a compound preparation, and the methods for preparing the pharmaceutical composition and the fixed dose of the compound preparation and the uses thereof.

Abstract: A lumen stent (100) and an implant are provided. The lumen stent includes a tubular body (11), an inner branch (12) and an outer branch (13) which are respectively communicated with the tubular body (11). The tubular body (11) includes a first body segment (111), a tapered segment (112) and a second body segment (113) which are connected in sequence. The tapered segment (112) is provided with an outer branch window (110b) and an inner branch window (110a). The proximal end of the outer branch (13) is connected to the outer branch window (110b). The distal end of the inner branch (12) is connected to the inner branch window (110a). The area of the inner branch window (110a) is larger than that of the outer branch window (110b).

Abstract: A flexible oximeter device for measuring pulse and blood oxygen saturation in tissue includes a first array of first light emitting elements that emit red light, a second array of second light emitting elements that emit green light or near-infrared (NIR) light and an array of sensor elements arranged on at least one flexible substrate. Each sensor element is configured to detect red and green or NIR light, and to output a signal representing an amount of red or green or NIR light detected. The first and second arrays and the array of sensor elements form a plurality of interleaved measurement pixels, each pixel comprising one of the first light emitting elements and a corresponding sensor element, and one of the second light emitting elements and a different corresponding sensor element.

Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: A staggered and crossed heat storage adsorption bed and a seawater desalination waste heat storage system are provided, which relate to the field of seawater desalination and the technical field of thermochemical adsorption heat storage. The adsorption bed includes a bed body, wherein an adsorption cavity is arranged in the bed body; two sides of the adsorption cavity are respectively communicated with an inlet cavity and an outlet cavity; the adsorption cavity includes a vacuum heat insulation layer arranged at an outermost side; the vacuum heat insulation layer is embedded with an adsorption box fixing layer; a corner end adsorption box, a central adsorption box and a side adsorption box are staggered and crossed arranged in an inner cavity of the vacuum heat insulation layer through the adsorption box fixing layer.

Abstract: An atomization generator and a special high-pressure atomization generation device for increasing oil and gas field recovery are provided. The special high-pressure atomization generation device for increasing oil and gas field recovery includes an agent pot assembly, a gear pump, a metering pump, an atomization generator and pipelines. The gear pump is connected with the agent pot assembly through an agent pot liquid inlet pipe. The metering pump is arranged between the agent pot assembly and the atomization generator which are connected through the low-pressure manifold pipeline and the high-pressure liquid inlet pipeline. The high-pressure liquid inlet pipeline is connected with the liquid inlet pipe. The liquid inlet pipes are connected with the metering pump. The gas inlet pipe is connected with the high-pressure gas source through the high-pressure gas inlet pipe. The gas inlet cap is provided with a gas inlet pipe.

Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.

Abstract: A catalyst including platinum (Pt) and a composite support. The composite support includes ZrO2/mesoporous silica sieve SBA-15. The platinum accounts for 0.01-0.3 wt. % of the catalyst. ZrO2 accounts for 5-20 wt. % of the composite support.

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

Abstract: There is provided a controlled-release antibiotic socket for securely holding an implantable medical device that is made from: at least one film having at least one polymer layer, where the at least one film is formed into the socket; at least one antibiotic agent; and at least one opening in the socket, where the at least one polymer layer comprises a biodegradable elastomeric polymeric material; and the at least one antibiotic agent is dispersed within at least one of the at least one polymer layers and/or, when the film comprises at least two polymer layers, the at least one antibiotic agent is disposed as a separate layer between two polymer layers. Also disclosed is the film used to make the socket and uses of both the socket and film.

Abstract: The present disclosure provides a kit and method for constructing a long-acting depression animal model. The present disclosure adopts Bacille Calmette-Guerin (BCG) (or Mycobacterium bovis (M bovis)) and low-dose pertussis toxin (PTX) for combined induction, which greatly reduces modeling cost. A mouse model constructed by the method of the present disclosure can clearly distinguish a time interval of pathological behaviors from a time interval of depression-like behaviors and has prominent face validity and predictive validity. The method of the present disclosure is simple and convenient and does not require a large number of tedious daily operations as the depression model construction by chronic unpredictable stress, chronic restraint stress, social defeat, mother-child separation, or the like. The mouse model of the present disclosure can provide a valuable long-term intervention window for research on antidepressant therapy.

Abstract: An application of fengycin family lipopeptides in pest control is provided, and Fengycin family lipopeptides are used for pest control, with especially strong killing effects on Homoptera and Coleoptera pests. A method is provided for treating seeds with fengycin to protect seeds and plant organs formed later from pests, so as to protect seeds from pests by coating the fengycin family lipopeptides on the surface of seeds.

Abstract: A method of starting an electronic device includes: receiving a first wireless signal carrying a first identification data by a wireless receiver before the electronic device enters a normal operating state; comparing the first identification data with a valid data; obtaining an account name and a password according to the first identification data if the first identification data matches the valid data and logging in to an operating system with the account name and the password so as to allow the electronic device to enter the normal operating state; and not logging in to the operating system if the first identification data does not match the valid data.

Abstract: In accordance with an embodiment, a network device has an input port for receiving input packets, and an output port for sending output packets, where the input packets and output packets have context layer information. The network device also includes a processor configured to process the input packets and output packets using a network protocol having a context layer.