Abstract: A leg massage machine capable of massaging popliteal fossa contains: a base, two swing arms, a first massager, and a second massager. The base includes a drive motor, and the drive motor has two driving shafts and two actuation blocks. The two actuation blocks have two eccentric posts. A respective one swing arm includes a drive segment and a driven segmenting. The drive segment has a fixing orifice, and a massaging unit is connected on the drive segment. The first massager includes two first protrusions and two first fixing shafts. At least one first protrusion has a first connecting orifice configured to connect with one actuating shaft of the two swing arms. The second massager includes two second protrusions and two second fixing shafts. At least one second protrusion has a second connecting orifice configured to connect with the other actuating shafts of the two swing arms.

Abstract: A maintenance base station includes at least one function component, a man-machine interaction component and a controller. The man-machine interaction component is configured to receive a user input and determine a man-machine interaction signal based on the user input. The man-machine interaction signal indicates a device type and a device task type. A device indicated with the device type at least includes a cleaning robot or the function component of the maintenance base station. The controller electrically connecting the function component and the man-machine interaction component, and is configured to receive the man-machine interaction signal and call the corresponding device to work based on the man-machine intction signal.

Abstract: A method of treating an aortopathy is disclosed, including identifying a subject having or at risk of developing the aortopathy and reducing the expression of and/or activity of gasdermin D (GSDMD) in the subject. The method may include administering to the subject an effective amount of a GSDMD inhibitor. The GSDMD inhibitor may reduce the expression of GSDMD in the subject and/or may reduce the activity of GSDMD in the subject.

Abstract: A die-casting aluminum alloy without heat-treatment and a preparation method and application thereof. Based on a total weight of the die-casting aluminum alloy, the die-casting aluminum alloy includes: 6.0 to 8.0 wt % of Si; 0.3 to 1.2 wt % of Mg; 0.4 to 0.8 wt % of Cu; 0.1 to 0.3 wt % of Fe; 0.6 to 0.8 wt % of Mn; 0.05 to 0.20 wt % of Ti; 0.03 to 0.07 wt % of Sr; 0.03 to 0.07 wt % of Ce; 0.01 to 0.04 wt % of La; 0.01 to 0.1 wt % of Zr; less than or equal to 0.01 wt % of other impurity elements; and a balance of Al.

Abstract: The present disclosure relates to a complex probiotic composition and a method for improving exercise performance of a subject with low intrinsic aerobic exercise capacity. The complex probiotic composition, which includes Lactobacillus rhamnosus GKLC1, Bifidobacterium lactis GKK24 and Clostridium butyricum GKB7, administered to the subject with the low intrinsic aerobic exercise capacity in a continuation period, can effectively reduce serum lactic acid and serum urea nitrogen after aerobic exercise, reduce proportion of offal fat and/or increase liver and muscle glycogen contents, thereby being as an effective ingredient for preparation of various compositions.

Abstract: A chemical mechanical polishing apparatus has a platen to support a polishing pad, a carrier head comprising a rigid housing and configured to hold a surface of a substrate against the polishing pad, a motor to generate relative motion between the platen and the carrier head so as to polish the substrate, an in-situ carrier head monitoring system including a sensor positioned to interact with the housing and to detect vibrational motion of the housing and generate signals based on the detected vibrational motion, and a controller. The controller is configured to generate a value for a carrier head status parameter based on received signals from the in-situ carrier head monitoring system, and change a polishing parameter or generate an alert based on the carrier head status parameter.

Abstract: The disclosure provides coronavirus mRNA vaccines, including vaccines directed against spike proteins of one or more variant strains of SARS-CoV-2, as well as methods of using the vaccines.

Abstract: The present disclosure provides a strengthened glass and a glass strengthening method, and an electronic device housing. Two opposing sides of the strengthened glass have surface compressive stress layers, and a third stress layer is sandwiched between the two surface compressive stress layers. The third stress layer includes a compressive stress region and multiple tensile stress regions spaced apart within the compressive stress region, the multiple tensile stress regions are extended in a thickness direction of the strengthened glass, and each of the tensile stress regions is surrounded by the compressive stress region. A sum of thicknesses of the surface compressive stress layers and a thickness of the compressive stress region located between two adjacent tensile stress regions is equal to a thickness of the strengthened glass.

Abstract: An internal rotor type nail drive device of electric nail gun, comprising a nailing rod and an internal rotor type rotary actuator that can output a specific rotation angle and can drive the nailing rod to move downward for nailing. Specifically, the rotary actuator comprises a stator and a rotor arranged inside the stator, even groups of electromagnetic mutual action components are configured in pairs between the stator and the rotor, to generate a tangential force to drive the rotor to rotate for a specific rotation angle, and to drive the nailing rod to move for a nailing stroke. The nailing stroke can be determined by a specific rotation angle. Thus, through the above configuration of the rotary actuator, the structure of the electric nail gun can be simplified, and the kinetic energy for nailing can be increased.

Abstract: The disclosure provides a method of dehydrogenating hydrocarbons, such as C2 or C3 hydrocarbons, selectively and efficiently, to provide the corresponding alkylenes. The method is based on a Pt nanolayer catalyst over MXene (Pt/MXene) that shows resistance to coke deposition. The dehydrogenation conditions developed provided about 22% propane conversion and over 90% selectivity toward the desired propylene product, and the catalyst was stable for a 24-hour continuous run. The byproducts were ethane, ethylene, and methane, and only trace amounts of coke deposition over the catalyst were detected. Similar dehydrogenation conditions provided about 18% ethane conversion and over 90% selectivity toward the desired ethylene product. A mass balance of greater than 96% was achieved in each case.

Abstract: The present disclosure relates to a method for treating a cancer and/or cancer metastasis in a subject comprising administering to the subject irinotecan loaded in a mesoporous silica nanoparticle. The present disclosure also provides a conjugate comprising an agent loaded in a mesoporous silica nanoparticle (MSN) defining at least one pore and having at least one functional group on a sidewall of the at least one pore.

Abstract: A pressure stabilizing cavum includes multiple PE pipes and a backing plate. The multiple PE pipes are inserted through a longitudinal keel of the ship. Each PE pipe is provided with a first opening. Both two sides of the each PE pipe in the width direction of the first opening are connected to a hull bottom plate of the ship to form a pressure stabilizing cavum. The backing plate is located between the each PE pipe and the hull bottom plate and is sealingly connected to the each PE pipe and the hull bottom plate. The backing plate is provided with a first through hole, and the hull bottom plate is provided with a second through hole communicating with the first through hole, and the pressure stabilizing cavum communicates with the outside of the ship through the first through hole and the second through hole.

Abstract: An electric treadmill includes a treadmill frame, an endless belt, a motor coupled to the endless belt for driving the endless belt to rotate, a brake device and a lifting device. The brake device has a rotating disc coaxially fixed to a motor shaft of the motor and a magnetic brake mechanism. The magnetic brake mechanism has at least one magnetic portion for applying a drag force against rotation of the rotating disc. The lifting device is operable to drive the magnetic brake mechanism to move between a first position where the magnetic portion is located close to the rotating disc and a second position where the magnetic portion is located away from the rotating disc. When there is no electric power supplied to the electric treadmill, the magnetic brake mechanism will automatically move to the first position due to gravity to stop rotation of the endless belt.

Abstract: A composition for forming a polyurethane foam is provided using polyol having a total unsaturation less than 0.04 meq/g, methylene diphenyl diisocyanate (MDI), and epoxidized soybean oil. The epoxidized soybean oil may comprise greater than about 5% by weight of the composition. A method for forming polyurethane foam using the aforementioned composition is also provided.

Abstract: This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.

Abstract: The present application is directed to, in part, nucleotide analogs with a novel design of a 3?-OH reversible terminator that comprises an enzyme-cleavable linkage.

Abstract: A dustproof counter device of a measuring wheel has a base, a counter, and a pedal setting component. The base has a component opening formed through a top of the base and a dustproof flange protruding from the base and surrounding the component opening. The counter is disposed in the base and has a zeroing button extending into the component opening of the base. The pedal setting component has a dustproof cap covering and surrounding the dustproof flange of the base, and abutting against the zeroing button. When the pedal setting component is pressed by a user's foot, dust is kept from dropping into the base by the dustproof cap.

Abstract: Immunogenic fusion proteins against infectious animal diseases. A fusion protein is disclosed, which comprises a CD40-binding domain; an antigen of a pathogen; a translocation domain located between the CD40-binding domain and the antigen, and a furin and/or cathepsin L cleavage site located between the CD40-binding domain and the translocation domain. Also disclosed are pharmaceutical compositions, expression vectors and use of the fusion proteins of the invention for eliciting an antigen-specific cell-mediated immune response, or for reducing, inhibiting, treating and/or ameliorating an infectious animal disease caused by a pathogen in an animal in need thereof.

Abstract: Disclosed is a method for vacuum electron beam welding of twinning-induced plasticity (TWIP) steel and use thereof. The welding method according to the present disclosure includes preheating welding, tack welding, and deep penetration welding. The method according to the present disclosure can achieve welding stability, a uniform butt joint width, small splash and full arc ending, and ensure that the internal quality of a welded joint meets requirements for an ISO13919-1 grade B butt joint, and the plasticity and tensile strength of the welded joint are equivalent to those of a base metal, thereby ensuring that the welded joint has a high energy-absorbing buffering function equivalent to that of a base metal. A vehicle anti-collision beam manufactured after welding and a vehicle energy-absorbing buffer component assembled by using the anti-collision beam have the advantages of light structure, high safety protection, etc.

Abstract: An optical element driving mechanism is for accommodating a first optical element and includes a fixed assembly, a movable part and a driving assembly. The movable part is configured to connect a second optical element, the second optical element corresponds to the first optical element, and the movable part is movable relative to the fixed assembly. The driving assembly is configured to drive the movable part to move relative to the fixed assembly. The fixed assembly includes a first accommodating space configured to accommodate the first optical element.