Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An article adapted to receive multiple battery cells, such as a battery module, which provides thermal insulation between adjacent battery cells using thermally insulating layers comprising a ceramifiable elastomeric silicone material, using fumed silica (amorphous SiO2) or fumed silica (amorphous SiO2)+quartz (crystalline SiO2). There is also provided, the use of said ceramifiable elastomeric silicone material as a means of delaying and/or preventing thermal runaway in such an article. Typically, the battery cells for which this article is designed are lithium-ion battery cells.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: Disclosed is a method of building a customized deep learning (DL) stack classifier to detect organization sensitive data in images, referred to as image-borne organization sensitive documents, and protecting against loss of the image-borne organization sensitive documents, including distributing a trained feature map extractor stack, with stored parameters, configured to allow the organization to extract from image-borne organization sensitive documents, feature maps that are used to generate updated DL stacks and to save non invertible feature maps derived from the images, and ground truth labels for the image. Also included is receiving organization-specific examples including the non-invertible feature maps extracted from the organization-sensitive documents and the ground truth labels and using the received organization-specific examples to update a customer-specific DL stack classifier. Further included is sending the customer-specific DL stack classifier to the organization.

Abstract: Systems and methods for treating a medical condition such as worsening heart failure (WHF) are described. A medical system may sense one or more physiological signals, and generate from the sensed physiological signals a signal metric trend indicating a progression of heart failure. A detector may detect a physiological event leading to WHF. A therapy control circuit may generate a therapy titration protocol using the generated signal metric trend. The therapy titration protocol includes a temporal profile of therapy dosage relative to a target dosage. The therapy control circuit may adjust the target dosage based on patient response. Therapies may be administered by a clinician or automatically delivered to the patient according to the therapy titration protocol.

Abstract: Apparatus and methods of enhanced DM-RS for enhanced PDCCH transmission with multiple beams from multiple TRPs are disclosed.

Abstract: Systems and methods for detecting worsening cardiac conditions such as worsening heart failure events are described. A system may include sensor circuits to sense physiological signals and signal processors to generate from the physiological signals first and second signal metrics. The system may include a risk stratifier circuit to produce a cardiac risk indication. The system may use at least the first signal metric to generate a primary detection indication, and use at least the second signal metric and the risk indication to generate a secondary detection indication. The risk indication may be used to modulate the second signal metric. A detector circuit may detect the worsening cardiac event using the primary and secondary detection indications.

Abstract: A coil decoupling method for a magnetic resonance imaging device, including: sending an instruction causing a transmitter to send a transmitted signal, acquiring a received signal received by a receiver, wherein the received signal is a signal arriving at the receiver after the transmitted signal passes through two coils to be adjusted of a plurality of coils, determining the coupling value between the two coils to be adjusted based on the transmitted signal and the received signal, and sending an instruction for adjusting a decoupling component based on the coupling value.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for acoustic echo cancellation and suppression are provided. An exemplary method comprises receiving a far-end acoustic signal and a corrupted near-end acoustic signal, wherein the corrupted near-end acoustic signal is generated based on (1) an echo of the far-end acoustic signal and (2) a near-end acoustic signal; feeding the far-end acoustic signal and the corrupted near-end acoustic signal into a neural network as an input to output a time-frequency (TF) mask that suppresses the echo and retains the near-end acoustic signal, and generating an enhanced version of the corrupted near-end acoustic signal by applying the obtained TF mask to the corrupted near-end acoustic signal.

Abstract: An apparatus includes a switching circuit, a resonant circuit coupled to an output of the switching circuit, a rectification circuit coupled between the resonant circuit and an output of the apparatus, and a controller coupled to the switching circuit. The controller, during a soft start-up operation of the power supply, is configured to switch a plurality of switches with a variable limited maximum duty cycle at a minimum frequency and after the variable limited maximum duty cycle reaches the limited maximum duty cycle at the minimum frequency, simultaneously switch the frequency to a maximum frequency and switch the duty cycle to a minimum duty cycle at the maximum frequency for a same on-time as the limited maximum duty cycle at the minimum frequency.

Abstract: A method for adapting an influenza virus to Vero cells is provided. The method comprises infecting Vero cells with the influenza virus, cultivating the infected Vero cells, harvesting influenza viruses of each passage, wherein infectious dose of the influenza viruses of one passage is greater than or equal to infectious dose of the influenza viruses of a previous passage. The present disclosure also relates to a composition. Said composition comprises polyriboinosinic acid-polyribocytidylic acid, at least one antibiotic or polyamide compound, at least one positive ion, influenza viruses and/or influenza antigens, wherein said influenza viruses and/or influenza antigens are acquired from Vero cell adapted influenza viruses.

Abstract: Systems and methods for assessing a patient's risk of renal dysfunction are described. A system may include sensor circuits to sense physiological signals and processors to generate signal metrics from the physiological signals. The system may generate a primary renal risk indication using a first signal metric, and a secondary renal risk indication using at least a second signal metric. The system may generate a composite renal risk indication and estimate a glomerular filtration rate or a chronic kidney disease stage using at least the primary and secondary risk indications. The composite renal risk indication, which indicative of a degree of renal dysfunction, may be presented to a clinician, or provided to a detector for detecting worsening heart failure.

Abstract: This document discusses, among other things, systems and methods to determine an alert state for each of a plurality of patients using received physiologic information, determine an event rate for the plurality of patients for a specific alert state, and adjust a composite HF risk determination for the plurality of patients using the determined event rate.

Abstract: The present disclosure describes techniques of encryption and decryption. The described techniques comprise obtaining a digital code to be encrypted; obtaining at least one predetermined rule; generating an encrypted digital code by rearranging and reorganizing bits comprised in the digital code to be encrypted based on the at least one predetermined rule; and delivering the encrypted digital code to a client computing device.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.

Abstract: Disclosed is an article adapted to receive multiple battery cells, such as a battery module, which provides thermal insulation between adjacent battery cells using thermally insulating layers comprising a ceramifiable elastomeric silicone material using calcium silicate fillers such as wollastonite. There is also provided, the use of said ceramifiable elastomeric silicone material as a means of delaying and/or preventing thermal runaway in such an article. Typically, the battery cells for which this article is designed are lithium-ion battery cells.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.