Abstract: The present application relates to a pharmaceutical composition comprising polynucleotides and use thereof for prevention or treatment of COVID-19. More specifically, disclosed in the present application is a composition used for prevention or treatment of COVID-19, comprising a polyriboinosinic-polyribocytidylic acid, an antibiotic or polyamino compound, a positive ion, and an optional antigen derived from novel coronavirus SARS-CoV-2. Also provided is use of the composition in preparation of a drug or vaccine for prevention or treatment of novel coronavirus SARS-CoV-2.

Abstract: An apparatus includes a switching circuit, a resonant circuit coupled to an output of the switching circuit, a rectification circuit coupled between the resonant circuit and an output of the apparatus, and a controller coupled to the switching circuit. The controller, during a soft start-up operation of the power supply, is configured to switch a plurality of switches with a variable limited maximum duty cycle at a minimum frequency and after the variable limited maximum duty cycle reaches the limited maximum duty cycle at the minimum frequency, simultaneously switch the frequency to a maximum frequency and switch the duty cycle to a minimum duty cycle at the maximum frequency for a same on-time as the limited maximum duty cycle at the minimum frequency.

Abstract: Methods of determining risk of recurrence of a breast cancer of a subject are provided. Also provided are methods of predicting responsiveness to a therapy of a breast cancer of a subject. Additionally, methods of recommending treatment for a subject that has breast cancer are provided. Further provided are methods of treating a subject that has breast cancer. Systems for performing described methods are also provided.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present disclose provides a touch control substrate and a display device and relates to the field of touch control technologies. The touch control substrate has a fingerprint recognition area and includes a plurality of touch control electrode units. The touch control electrode unit includes a mesh electrode composed of a plurality of electrode lines, and at least one touch control electrode unit is located in the fingerprint recognition area. The touch control electrode unit in the fingerprint recognition area is divided into a first area and a second area surrounding the first area, and a coverage rate of the plurality of electrode lines in the first area is smaller than a coverage rate of the plurality of electrode lines in the second area.

Abstract: The present application discloses a human T-lymphoblastic leukemia/lymphoma cell strain named as ZYXY-T1, and its construction method and use thereof. It was conserved in China Center for Type Culture Collection (Wuhan, China) on Jan. 20, 2021, and the preservation number was CCTCC NO: C202143. The present application is obtained by separating mononuclear cells from peripheral blood of one ETP-ALL patient, and culturing the cells in vitro for continuous natural passage. The strain has the typical surface antigen expression characteristics of ETP-ALL, that is, it does not express CD1?, CD5 or CD8, and highly expresses a stem cell marker CD34, and has good proliferation ability in vitro and tumorigenesis ability in vivo; it can be used as a cell material to study the occurrence and development mechanism of ETP-ALL, and can also be used to screen and evaluate ETP-ALL drugs to guide clinical medication.

Abstract: The present disclosure relates to a use of Nocardia rubra cell wall skeleton in regenerative medicine, and in particular, to a use of Nocardia rubra (especially the cell wall skeleton thereof) in the following aspects: promoting proliferation, growth, differentiation and migration of stem cells, and improving the survival rate of the stem cells, wherein the stem cells are selected from: adult stem cells, iPSCs, and mesenchymal stem cells.

Abstract: The present invention provides, in part, cyclic amino acid lipid compounds of formula (A?), and sub-formulas thereof or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiquitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.

Abstract: The present application provides a method of making a particle comprising (i) obtaining a first solution comprising a negatively charged polysaccharide; (ii) obtaining a second solution comprising a positively charged polysaccharide; and (iii) mixing the first solution and the second solution to obtain a suspension comprising the particle. The present application also provides a method of making a therapeutic particle, comprising: (i) obtaining a solution comprising a therapeutic protein; (ii) obtaining a first suspension comprising the particle comprising a negatively charged polysaccharide and a positively charged polysaccharide, and (iii) mixing the solution of the therapeutic protein and the first suspension to obtain a second suspension comprising the therapeutic particle. The present application also provides particles (e.g.

Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are a method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

Abstract: The present disclosure relates to a desalination system of photovoltaic direct-driven membrane capacitive deionization. The system includes a photovoltaic direct-driven group and a municipal power grid-connected group. The photovoltaic direct-driven group includes a photovoltaic power collection unit, a power storage unit, a direct-driven power monitoring unit, a voltage adjustment unit, and a membrane capacitive deionization water purification unit. The municipal power grid-connected group includes a grid-connected control unit, a grid busbar unit, and an intelligent detection unit.

Abstract: A display module and a display device are disclosed. The display module includes a display panel, a heat dissipation film disposed on a side of the display panel facing away from a display side, and an ultrasonic fingerprint module. The heat dissipation film is provided with a first opening, and the ultrasonic fingerprint module includes a sensor disposed within the first opening and fixed on the side of the display panel facing away from the display side by a shading adhesive layer. The display module further includes a light shielding sheet attached on a side of the heat dissipation film facing away from the display panel. The light shielding sheet is provided with a second opening which exposes the sensor. An orthographic projection of the light shielding sheet and the shading adhesive layer on the display panel includes an orthographic projection of the first opening on the display panel.

Abstract: Provided is a use of Rhodococcus ruber cell wall skeleton in promoting the proliferation of stem cells, promoting the growth of stem cells, promoting the differentiation of stem cells, promoting the migration of stem cells, and improving the survival rate of stem cells; the stem cells are selected from: adult stem cells, iPSCs, and mesenchymal stem cells.

Abstract: An image sensor includes an image sensor pixel array having pixels. Each pixel includes a continuous active region having a first portion and a second portion extending from the first portion. A photodiode, a reset transistor, a drive transistor, and a select transistor are formed in and over the first portion. The photodiode and the reset transistor define a floating diffusion region therebetween. A switch transistor is formed in and over the second portion and includes a first source/drain region and a second source/drain region. The first source/drain region is included in the floating diffusion region. The second source/drain region interfaces a doped region formed in the second region. The pixel also includes a gate structure disposed directly over the doped region. By controlling the switch transistor, the pixel may operate in a high conversion gain mode or a low conversion gain mode to accommodate different illumination or exposure conditions.

Abstract: An integrated tunable waveguide element includes: a cladding. A high k dielectric layer is disposed within the cladding. At least one waveguide is disposed adjacent to the high k dielectric layer. At least one two dimensional monolayer pad is disposed on or in the high k dielectric layer adjacent to a portion of the at least one waveguide. An integrated 2×2 array element is also described.

Abstract: A resource configuration indication method includes that: the terminal device sends time domain resource indication information, wherein the time domain resource indication information is configured to indicate a transmission period and the number of time domain resource units.

Abstract: A touch structure and a touch display panel are provided. The touch structure includes a first touch; the first touch electrode includes a plurality of first touch electrode portions connected in series, each of the first touch electrode portions includes a first main body portion and a plurality of first finger portions, and the plurality of first finger portions protrude from the first main body portion; at least one first finger portion of at least one of the plurality of first touch electrode portions includes a first finger effective electrode and a first finger dummy electrode, the first finger dummy electrode is insulated from the first finger effective electrode, and the first finger effective electrode is connected with the first main body portion.

Abstract: Disclosed is a fully convolutional genetic neural network method for segmentation of infant brain record images. First, infant brain record image data is input and preprocessed, and genetic coding initialization is performed for parameters according to the length of a DMPGA-FCN network weight. Then, m individuals are randomly grouped into genetic native subpopulations and corresponding twin subpopulations are derived, where respective crossover probability and mutation probability pm of all the subpopulations are determined from disjoint intervals; and an optimal initialization value fa is searched for by using a genetic operator. Afterwards, fa is used as a forward propagation calculation parameter and a weighting operation is performed on the feature address featuremap.