Abstract: A carton for containing a plurality of articles. The carton includes a plurality of panels that extends at least partially around an interior of the carton. The plurality of panels comprising a top panel, a bottom panel, a first side panel, and a second side panel. An article protection insert comprises a plurality of features for engaging a respective article of the plurality of articles. At least one access feature is in the top panel for positioning the article protection insert to a position wherein the features engage at least one article of the plurality of articles.

Abstract: A circuit, e.g., a CMOS sensor, with individually addressable transfer transistors and individually addressable reset transistors is described. Through the individually addressable transistors, pixels within different regions of interest, of the same or different size and/or the same or different exposure times, can be efficiently processed. Different regions of interest may be exposed concurrently and read out independently.

Abstract: The invention relates to biomaterials, which comprise a bacterial cellulose matrix and probiotics entrapped in said bacterial cellulose. The invention also relates to methods for obtaining the biomaterial, as well as uses of the biomaterial in medicine. It also relates to coated food products wherein the coat is composed of said biomaterial wherein the coat acts to prevent the proliferation of undesired bacteria. It also relates to packaged medical devices, wherein the package comprises said biomaterial also preventing growth of pathogenic bacteria.

Abstract: An analogue to digital converter is provided for digital imaging devices, in which a pixel column is sampled by a respective capacitor. In a reset phase of operation, each pixel in the row under consideration is reset, and an operational amplifier operating in a voltage follower mode is coupled to all the sampling capacitors in parallel to obtain the reset values of the pixels sensors of that row, and the in an imaging phase of operation, the inverting input of the operational amplifier operating in a comparator mode is coupled to each capacitor in turn after activating the respective pixel sensor, while exposing the non inverting signal to an analog ramp reference voltage so that the timing of the toggling of the operational amplifier reflects the value of the pixel under consideration, corrected for the reset value.

Abstract: A CMOS optical sensor comprises spare readout channels to replace readout channels found defective at the end of the manufacturing process. These spare readout channels are dispatched over the width of the optical sensor (corresponding to the row direction) in the form of spare groups Gm1, Gm2, Gm3 of m spare readout channels each, m integer at least equal to 1. Each spare group is inserted between two successive default groups Gn1 and Gn2 of n default readout channels each and coupling means SW1 are configured to replace a defective default readout channel in a default group as well as any default readout channels of the group between the defective one and the spare group next to the default group of concern.

Abstract: The invention relates to biological biocomposites which comprise a collagen scaffold containing probiotics entrapped into the collagen scaffold and exopolysaccharides. The invention also relates to methods for obtaining the biocomposites as well as to the use of biocomposites in medicine and, more in particular, in the treatment of bacterial vaginosis.

Abstract: An analogue to digital converter for converting the analogue output of a dual conversion gain pixel of an image sensor. The dual conversion gain pixel is operable to sequentially output a reset pixel value and a signal pixel value sequentially with both a first gain and a second gain different to the first gain. An image sensor comprising the analogue to digital converter, a system comprising the image sensor and a method are also described herein.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: A CMOS optical sensor comprises spare readout channels to replace readout channels found defective at the end of the manufacturing process. These spare readout channels are dispatched over the width of the optical sensor (corresponding to the row direction) in the form of spare groups Gm1, Gm2, Gm3 of m spare readout channels each, m integer at least equal to 1. Each spare group is inserted between two successive default groups Gn1 and Gn2 of n default readout channels each and coupling means SW1 are configured to replace a defective default readout channel in a default group as well as any default readout channels of the group between the defective one and the spare group next to the default group of concern.

Abstract: The invention relates to a pro-biofilm coating applied by means of cold atmospheric plasma polymerization of a precursor on a substrate. The coating has a roughness such that it promotes the creation of more than 100% biofilm on the substrate, where the 100% of biofilm is the one as produced on the same substrate being devoid of said pro-biofilm coating. The invention also relates to a method of producing said pro-biofilm coating and a substrate coated with same.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: A direct TOF optic sensor is based on CMOS pixels, wherein a pixel structure comprises a photodetector PhD, a non linear resistance R and a transfer MOS transistor in series, and delivers an output signal at a sensing node SN between the resistor and the transfer transistors. The photogenerated current is continuously drained into the nonlinear resistance and converted to a voltage signal by the RC circuit formed by the nonlinear resistance and a capacitance at the sense node SN. The voltage signal is continuously transmitted to a readout circuitry 300 having a fast analog to digital converter. The RC circuit within the pixel structure has a low pass filtering function and a high frequency integrating function, so that noise, in particular thermal noise due to the nonlinear resistance is mainly shifted in a low frequency range, separate from a high frequency range of the main signal component corresponding to a pulse light signal received at the photodetector.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: A circuit, e.g., a CMOS sensor, with individually addressable transfer transistors and individually addressable reset transistors is described. Through the individually addressable transistors, pixels within different regions of interest, of the same or different size and/or the same or different exposure times, can be efficiently processed. Different regions of interest may be exposed concurrently and read out independently.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: In various embodiments, a drainage device includes an inner lumen configured for draining fluid from a target site and one or more outer lumens for transmitting dilution fluid to the inner lumen. According to one embodiment, the drainage device includes one or more eyelets and/or a distal opening through which the fluid from the target site enters the inner lumen. In one or more embodiments, the dilution fluid is transmitted to the inner lumen through one or more ports that may output the dilution fluid directly into the inner lumen or into the eyelet. According to one embodiment, as the fluid from the target site flows through the drainage device, the dilution fluid reduces clotting processes such that formation of blockages within the inner lumen is prevented or at least reduced. In some embodiments, the dilution fluid is substituted with, or provided in addition to, pharmaceutical solutions or other infusions.

Abstract: A carton for containing a plurality of articles. The carton includes a plurality of panels that extends at least partially around an interior of the carton. The plurality of panels comprising a top panel, a bottom panel, a first side panel, and a second side panel. An article protection insert comprises a plurality of features for engaging a respective article of the plurality of articles. At least one access feature is in the top panel for positioning the article protection insert to a position wherein the features engage at least one article of the plurality of articles.