Abstract: The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A carton for containing at least one article. The carton includes a plurality of panels at least partially forming an interior of the carton. The plurality of panels include a top panel. The carton includes an article protection flap foldably connected to at least one panel of the plurality of panels. The article protection flap is moveable between a first position that is substantially parallel to the top panel and a second position wherein the article protection flap is folded relative to the top panel. The at least one access feature in the top panel is for positioning the article protection flap from the first position to the second position.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The invention relates to a feeding carriage for a compressor machine of the type having an upper filling end through which a particulate material which is to be compressed in a mold of the compressor machine is introduced, and a lower discharging end for discharging said particulate material towards said mold. At least some of the elements forming said feeding carriage can move with respect to one another, which thereby allows modifying the geometry of at least one of said lower discharging end, said upper filling end and an intermediate portion of the supply carriage located between both ends. The invention also relates to the use of such a feeding carriage comprising the initial steps of determining optimum carriage geometry for a particulate material which is to be compressed and applying said optimum carriage geometry to the feeding carriage.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor of Formula (I).

Abstract: A carton for holding a plurality of containers. The carton comprises a plurality of panels that extends at least partially around an interior of the carton. At least two end flaps can cooperate to at least partially form a closed end of the carton. A reinforcing insert comprises a central panel and at least one reinforcing end flap. The central panel can be at least partially disposed in the interior of the carton, and the at least one reinforcing end flap can comprise a base portion and a distal portion foldably connected to the base portion. The base portion extends in an oblique direction from the central panel toward the closed end of the carton.

Abstract: The present invention relates to fire resistant sustainable sandwich panels comprising a thermoplastic foam core in between outer skins made of natural fibres set within a natural thermoset biopolymer. The sandwich panels are provided with a fire resistant protective coating on an outer surface. This surface may be the surface facing the cabin when installed in an aircraft interior. Such fire resistant sustainable panels provide the required flame and heat resistance, have a high strength-to-weight ratio, low maintenance costs and are generally easily installed. Furthermore, the fire resistant sustainable sandwich panels allow easy recycling and are cheaper than conventional sandwich panels.

Abstract: The present invention relates to method of manufacturing an aircraft interior panel comprising a core sandwiched between first and second skins, wherein both of the first and second skins are formed from natural fibres containing non-halogenated fire-retardant and set within an inorganic thermoset resin, thereby forming a fire-resistant sustainable aircraft interior panel. The method comprises impregnating the natural fibres with non-halogenated fire retardant and an inorganic thermoset resin, and laying up the resin-impregnated natural fibres to sandwich the core. This stack is then cured by raising the temperature of the stack sufficient to initiate curing but without reaching the boiling point of water in the stack, holding the stack at that first temperature before raising the temperature again to reach the boiling point of water in the stack, before cooling the stack.

Abstract: A carton for containing at least one article. The carton includes a plurality of panels that extends at least partially around the interior of the carton. The plurality of panels comprises a top panel, a bottom panel, a first side panel, and a second side panel. At least one article retention panel is for retaining the at least one article. The article retention panel is foldably connected to the at least one panel. The article retention panel is positioned relative to the at least one panel to contact the at least one article.

Abstract: A carton for containing at least one article. The carton includes a plurality of panels that extends at least partially around the interior of the carton. The plurality of panels comprises a top panel, a bottom panel, a first side panel, and a second side panel. At least one article retention panel is for retaining the at least one article. The article retention panel is foldably connected to the at least one panel. The article retention panel is positioned relative to the at least one panel to contact the at least one article.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A carton for containing a plurality of articles. The carton can comprise a plurality of panels that extends at least partially around an interior of the carton. The plurality of panels can comprise an inner top panel and an outer top panel that at least partially overlaps the inner top panel. An outer end flap can be foldably connected to the outer top panel at an upper corner of the carton, and the outer end flap can at least partially close an end of the carton. A handle can comprise a handle panel defined in at least the inner top panel and a handle flap defined in the outer end flap. The handle panel can be mounted to the handle flap so that a portion of the handle panel is covered by the upper corner.

Abstract: A carton for holding a plurality of containers. The carton comprises a plurality of panels that extends at least partially around an interior of the carton. The plurality of panels comprises at least one top panel, at least one side panel foldably connected to the at least one top panel, and a bottom panel foldably connected to the at least one side panel. The carton further comprises a support foldably connected to the top panel for supporting at least one article of the plurality of articles and a dispenser for allowing removal of the plurality of articles from the carton. The dispenser comprises a dispenser panel that is at least partially defined by a tear line in the at least one side panel and the at least one top panel. The dispenser panel is for being at least partially removed for at least further opening a dispenser opening.

Abstract: A carrier that is at least partially holding a plurality of containers. The carrier can include a plurality of panels comprising a bottom panel, a first side panel foldably connected to the bottom panel, a second side panel foldably connected to the bottom panel, a first top panel foldably connected to the first side panel, and a second top panel foldably connected to the second side panel. At least one container-receiving feature extends in at least the bottom panel. The at least one container-receiving feature can at least partially receive at least one container of the plurality of containers. At least one retention flap is foldably connected to the first top panel or the second top panel. The at least one retention flap engages at least a portion of a flange of at least one container.

Abstract: A carton for containing at least one article. The carton comprises a plurality of panels at least partially forming an interior of the carton. The plurality of panels comprises a top panel. The carton comprises an article protection flap foldably connected to at least one panel of the plurality of panels. The article protection flap is moveable between a first position that is substantially parallel to the top panel and a second position wherein the article protection flap is folded relative to the top panel. The at least one access feature in the top panel is for positioning the article protection flap from the first position to the second position.

Abstract: A carton for containing at least one article. The carton includes a plurality of panels that extends at least partially around the interior of the carton. The plurality of panels comprises a top panel, a bottom panel, a first side panel, and a second side panel. At least one article retention panel is for retaining the at least one article. The article retention panel is foldably connected to the at least one panel. The article retention panel is positioned relative to the at least one panel to contact the at least one article.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.