Patents by Inventor Anastasia Khvorova

Anastasia Khvorova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATED OLIGONUCLEOTIDES
    Publication number: 20240084297
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: February 16, 2023
    Publication date: March 14, 2024
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS
  • OPTIMIZED ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
    Publication number: 20240067967
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Application
    Filed: May 23, 2023
    Publication date: February 29, 2024
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • OLIGONUCLEOTIDES FOR PMS1 MODULATION
    Publication number: 20240052344
    Abstract: This disclosure relates to novel PMS1 targeting sequences. Novel PMS1 targeting oligonucleotides for the treatment of trinucleotide repeat disease or disorder are also provided.
    Type: Application
    Filed: May 3, 2023
    Publication date: February 15, 2024
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Chantal Ferguson, Jillian Belgrad
  • Branched oligonucleotides
    Patent number: 11896669
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • OLIGONUCLEOTIDES FOR PMS2 MODULATION
    Publication number: 20240035027
    Abstract: This disclosure relates to novel PMS2 targeting sequences. Novel PMS2 targeting oligonucleotides for the treatment of a trinucleotide repeat disease or disorder are also provided.
    Type: Application
    Filed: May 3, 2023
    Publication date: February 1, 2024
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Chantal Ferguson, Jillian Belgrad
  • OLIGONUCLEOTIDES FOR ATN1 MODULATION
    Publication number: 20230416735
    Abstract: This disclosure relates to novel ATN1 targeting sequences. Novel ATN1 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: April 13, 2023
    Publication date: December 28, 2023
    Inventors: Anastasia Khvorova, Daniel O'Reilly
  • PROTECTING OLIGONUCLEOTIDES FOR CRISPR GUIDE RNA
    Publication number: 20230407295
    Abstract: Protecting oligonucleotides are provided. Protecting oligonucleotides with 5? and/or 3? conjugated moieties are provided. Protecting oligonucleotides with chemical modifications are provided. Methods of using the protecting oligonucleotides for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: April 28, 2023
    Publication date: December 21, 2023
    Inventors: Han Zhang, Erik Joseph Sontheimer, Jonathan Kenneth Watts, Anastasia Khvorova
  • EXOSOMAL LOADING USING HYDROPHOBICALLY MODIFIED OLIGONUCLEOTIDES
    Publication number: 20230399659
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Application
    Filed: October 18, 2022
    Publication date: December 14, 2023
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • OPTIMIZED SIRNA SCAFFOLDS
    Publication number: 20230399645
    Abstract: This disclosure relates to novel modified oligonucleotides with increased stability and extended in vivo mRNA silencing activity.
    Type: Application
    Filed: May 16, 2023
    Publication date: December 14, 2023
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Vignesh Narayan Hariharan, Clemens Lochmann, David Cooper
  • OLIGONUCLEOTIDES FOR APP MODULATION
    Publication number: 20230392146
    Abstract: This disclosure relates to novel APP targeting sequences. Novel APP targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: March 10, 2023
    Publication date: December 7, 2023
    Inventors: Anastasia Khvorova, Chantal Ferguson, Sarah Davis
  • Modified oligonucleotides targeting SNPs
    Patent number: 11827882
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: November 28, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Modified oligonucleotides with increased stability
    Patent number: 11820985
    Abstract: This disclosure relates to novel modified oligonucleotides. Novel modified siRNA are also provided.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: November 21, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Loïc Maurice René Jean Roux, Ken Yamada
  • OLIGONUCLEOTIDES FOR MECP2 MODULATION
    Publication number: 20230348907
    Abstract: This disclosure relates to novel MECP2 targeting sequences. Novel MECP2 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: January 9, 2023
    Publication date: November 2, 2023
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan
  • OLIGONUCLEOTIDES FOR MLH1 MODULATION
    Publication number: 20230340475
    Abstract: This disclosure relates to novel MLH1 targeting sequences. Novel MLH1 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: December 16, 2022
    Publication date: October 26, 2023
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Chantal Ferguson, Jillian Belgrad
  • OLIGONUCLEOTIDES FOR MLH3 MODULATION
    Publication number: 20230313198
    Abstract: This disclosure relates to novel MLH3 targeting sequences. Novel MLH3 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: December 16, 2022
    Publication date: October 5, 2023
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Chantal Ferguson, Jillian Belgrad
  • Modified oligonucleotides targeting SNPs
    Patent number: 11767527
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Conjugated oligonucleotides
    Patent number: 11753638
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: September 12, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin, Annabelle Biscans
  • Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
    Patent number: 11702659
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: July 18, 2023
    Assignees: UNIVERSITY OF MASSACHUSETTS, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • OLIGONUCLEOTIDES FOR SOD1 MODULATION
    Publication number: 20230193281
    Abstract: This disclosure relates to novel SOD1 targeting sequences. Novel SOD1 targeting oligonucleotides for the treatment of SOD1-related familial amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: November 8, 2022
    Publication date: June 22, 2023
    Inventors: Anastasia Khvorova, James W. Gilbert, Chantal Ferguson, Robert Brown, Alexandra Weiss
  • MODIFIED GUIDE RNAS FOR NEISSERIA MENINGITIDIS CAS9
    Publication number: 20230183687
    Abstract: Chemically modified Neisseria meningitidis (Nme) crRNAs, tracrRNAs, and sgRNAs are provided. Methods of using the Nme crRNAs, tracrRNAs, and sgRNAs for genome editing with a Nme CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: October 12, 2022
    Publication date: June 15, 2023
    Inventors: Erik Joseph Sontheimer, Jonathan Kenneth Watts, Anastasia Khvorova, Nathan Bamidele