Patents by Inventor Anastasia Khvorova

Anastasia Khvorova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12077755
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: September 3, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • Publication number: 20240287514
    Abstract: This disclosure relates to novel IFN-? signaling pathway target gene targeting sequences. Novel IFNGR1, JAK1, JAK2, and STAT1 targeting oligonucleotides for the treatment of vitiligo are also provided.
    Type: Application
    Filed: December 21, 2023
    Publication date: August 29, 2024
    Inventors: Anastasia Khvorova, John E. Harris, Qi Tang
  • Patent number: 12049627
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: July 30, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • Patent number: 12037585
    Abstract: This disclosure relates to a therapeutic combination of drugs for the treatment or management of a neurodegenerative disease, the combination comprising: a first conjugate comprising an RNA silencing agent and a first targeting agent that targets the first conjugate to the central nervous system, and a second conjugate comprising an antagonist of the RNA silencing agent and a second targeting agent that targets the second conjugate to a off-target tissue.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: July 16, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Chantal Ferguson
  • Patent number: 12024706
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: July 2, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Patent number: 12023407
    Abstract: Novel artificial exosomes and methods for producing novel artificial exosomes are provided. Methods of delivering cargo molecules to a cell using artificial exosomes are also provided.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: July 2, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Reka Agnes Haraszti, Anastasia Khvorova, Neil Aronin
  • Publication number: 20240182904
    Abstract: Provided herein are oligonucleotides (e.g., siRNA) targeting S6K1. Also provided are methods of treating a disease associated with S6K1 expression.
    Type: Application
    Filed: September 29, 2023
    Publication date: June 6, 2024
    Inventors: Claudio Punzo, Anastasia Khvorova, Dimas Echeverria Moreno, Annabelle Biscans, Julia F. Alterman, Matthew Hassler, Shun-Yun Cheng, Jillian Caiazzi
  • Publication number: 20240173420
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific eye distribution.
    Type: Application
    Filed: September 29, 2023
    Publication date: May 30, 2024
    Inventors: Claudio Punzo, Anastasia Khvorova, Dimas Echeverria Moreno, Annabelle Biscans, Julia F. Alterman, Matthew Hassler, Shun-Yun Cheng
  • Publication number: 20240167029
    Abstract: Extended Nucleic Acid (exNA)-modified crRNAs and tracrRNAs are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: June 23, 2023
    Publication date: May 23, 2024
    Inventors: Anastasia Khvorova, Ken Yamada, Erik Joseph Sontheimer
  • Publication number: 20240141362
    Abstract: This disclosure relates to novel modified oligonucleotides. Novel modified siRNA are also provided.
    Type: Application
    Filed: September 1, 2023
    Publication date: May 2, 2024
    Inventors: Anastasia Khvorova, Loïc Maurice René Jean Roux, Ken Yamada
  • Publication number: 20240132892
    Abstract: This disclosure relates to novel C9ORF72 targeting sequences. Novel oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: June 9, 2023
    Publication date: April 25, 2024
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, James W. Gilbert
  • Publication number: 20240132888
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: August 9, 2023
    Publication date: April 25, 2024
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Publication number: 20240084297
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: February 16, 2023
    Publication date: March 14, 2024
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS
  • Publication number: 20240067967
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Application
    Filed: May 23, 2023
    Publication date: February 29, 2024
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • Publication number: 20240052344
    Abstract: This disclosure relates to novel PMS1 targeting sequences. Novel PMS1 targeting oligonucleotides for the treatment of trinucleotide repeat disease or disorder are also provided.
    Type: Application
    Filed: May 3, 2023
    Publication date: February 15, 2024
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Chantal Ferguson, Jillian Belgrad
  • Patent number: 11896669
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • Publication number: 20240035027
    Abstract: This disclosure relates to novel PMS2 targeting sequences. Novel PMS2 targeting oligonucleotides for the treatment of a trinucleotide repeat disease or disorder are also provided.
    Type: Application
    Filed: May 3, 2023
    Publication date: February 1, 2024
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Chantal Ferguson, Jillian Belgrad
  • Publication number: 20230416735
    Abstract: This disclosure relates to novel ATN1 targeting sequences. Novel ATN1 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: April 13, 2023
    Publication date: December 28, 2023
    Inventors: Anastasia Khvorova, Daniel O'Reilly
  • Publication number: 20230407295
    Abstract: Protecting oligonucleotides are provided. Protecting oligonucleotides with 5? and/or 3? conjugated moieties are provided. Protecting oligonucleotides with chemical modifications are provided. Methods of using the protecting oligonucleotides for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: April 28, 2023
    Publication date: December 21, 2023
    Inventors: Han Zhang, Erik Joseph Sontheimer, Jonathan Kenneth Watts, Anastasia Khvorova
  • Publication number: 20230399659
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Application
    Filed: October 18, 2022
    Publication date: December 14, 2023
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti