Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A mechanism that allows CE-to-PE traffic to achieve minimal traffic loss at the same rate as PE-to-CE redirection (FRR). The solution relies on a fast-unblocking of the Backup-DF interface based on appearance of redirected packets from the active DF-Elected peer. A slow-path confirmation mechanism is included to further mitigate false-positives, as well as maintaining data plane and control plane in sync.

Abstract: Embodiments described herein relate to systems and methods for content summary generation within a content collaboration system. A graphical user interface for a platform of the system may include selectable graphical objects, which may contain a portion of content obtained from target content, and other selectable elements and graphics. A user may be provided with an input to request a summary of the target content. The system may generate a prompt and provide to a generative output engine instructions to prepare such summary, and generate within the graphical user interface a summary including natural language. The summary may be a summary of a page, a set of messages, a list of actions, key decisions, or items and summaries related to the target content. Processing may include populating the summary with system-specific mentions, links, tables, video, audio, and so on, which may be specific to permissions for the user.

Abstract: The invention provides novel heterocyclic compounds having the general formula (I) or (II), and pharmaceutically acceptable salts thereof, wherein the variables are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds for the treatment or prevention of acute neurological disorders, chronic neurological disorders and/or cognitive disorders.

Abstract: The present document discloses a method and system for blocking a computer system based on tickets issued by a remote server, with an operating system configured for booting from a UEFI, wherein the blocking system comprises: a transfer engine, i.e. an agent, of tickets comprised in an application or module of the operating system; an authentication engine comprised in said UEFI; a data or file transfer area accessible by both engines; wherein the transfer engine is configured for receiving tickets and storing tickets; wherein the authentication engine is configured for: reading a stored ticket; checking authentication and obtaining read ticket type; and if the authenticity is verified, processing the verified ticket, depending on the type: a normal ticket, setting the system to a leased state wherein the operating system can start; or a block ticket, setting the system to a blocked state wherein the operating system cannot boot.

Abstract: A robotic cleaner includes a housing, a suction conduit with an opening, and a leading roller mounted in front of a brush roll. An inter-roller air passageway may be defined between the leading roller and the brush roll wherein the lower portion of the leading roller is exposed to a flow path to the suction conduit and an upper portion of the leading roller is outside of the flow path. Optionally, a combing unit includes a plurality of combing protrusions extending into the leading roller and having leading edges not aligned with a center of the leading roller. Optionally, a sealing strip is located along a rear side of the opening and along a portion of left and right sides of the opening. The underside may define side edge vacuum passageways extending from the sides of the housing partially between the leading roller and the sealing strip towards the opening.

Abstract: The invention relates to a method for coating a textile hose (4) with a thermoplastic sealing material (5), in particular polyurethane-based, in a coating device (2). The textile hose (4) has a longitudinal direction and a circumferential direction and is manufactured continuously in the longitudinal direction and in the circumferential direction, in particular formed from a tubular knit hose; the textile hose (4) is fed to the coating device (2) and is continuously drawn onto a mandrel (6) extending in the longitudinal direction and approximately in the vertical direction (8) and is continuously transported further over this mandrel (6), the mandrel (6) being supported and oriented according to the position by at least one support means (10) provided outside the textile hose (4).

Abstract: The invention relates to a composition comprising leguminous proteins textured in a dry process, to a method for the production thereof and to the use thereof.

Abstract: The invention provides a partial power DC-DC converter with controllable topology comprising: a galvanically isolated DC-DC converter having a positive input, a negative input, a positive output, and a negative output; a first DC voltage input electrically connected to said negative output of the DC-DC converter; an input reference; a first DC voltage output electrically connected to said positive output of the DC-DC converter; and an output reference electrically connected to said input reference and said negative input of the DC-DC converter; wherein said partial power DC-DC converter additionally comprises: a first switch arranged to selectively connect said first DC voltage input to said positive input of the DC-DC converter; and a second switch arranged to selectively connect said positive output of the DC-DC converter to said positive input of the DC-DC converter.

Abstract: A stackable, embeddable capacitor has one or more first type vertical capacitor elements, each of which has a top cathode, a bottom anode, and a first orientation central capacitance region between the top cathode and the bottom anode. The capacitor also has one or more second type vertical capacitor elements, each of which has a bottom cathode, a top anode, and a second orientation central capacitance region between the bottom cathode and the top anode. The second type vertical capacitor elements are alternatingly stacked on the first type vertical capacitor elements.

Abstract: A vehicular scalable integrated control system includes a plurality of sensors and a vehicular scalable integrated control unit. The plurality of sensors includes a plurality of cameras and a plurality of radar sensors. Data captured by the sensors is provided as input to and is processed at the vehicular scalable integrated control unit. Responsive at least in part to processing at the vehicular scalable integrated control unit of data captured by the plurality of sensors, the vehicular scalable integrated control system at least partially controls at least one selected from the group consisting of (i) braking of the vehicle while being driven along a road and (ii) steering of the vehicle while being driven along the road. The plurality of cameras includes a front camera disposed at an in-cabin side of a windshield of the vehicle. The front camera views through the windshield forward of the vehicle.

Abstract: A non-transitory computer-readable medium stores instructions readable and executable by at least one electronic processor (181, 182, 20) to perform an imaging method (100). The method includes: reconstructing emission imaging data to generate an emission image of a lesion; converting intensity values of the emission image to at least one standardized uptake value (SUV value) for the lesion; processing input data using a regression neural network (NN) (28) to output an SUV correction factor for the lesion, wherein the input data includes at least two of (i) image data comprising the emission image or a feature vector representing the emission image, (ii) the at least one SUV value, (iii) a size of the lesion, and (iv) reconstruction parameters used in the reconstructing; and controlling a display device (24) to display at least one of (I) the SUV correction factor and (II) a corrected SUV value generated by applying the SUV correction factor to the at least one SUV value.

Abstract: Operating a wind turbine generator (WTG) comprising a pitch control system, the operation comprising: a) operating the WTG in a normal mode while the WTG is connected to an external grid; b) controlling the pitch angle of the blades using a normal pitch control mode while the WTG is operating in the normal mode; c) detecting a grid loss; d) operating the WTG in a standby mode during the grid loss; and e) controlling the pitch angle of the blades in dependence on a monitored speed parameter of the WTG using a standby pitch control mode different to the normal pitch control mode while the WTG is operating in the standby mode, wherein the standby pitch control mode is less responsive than the normal pitch control mode such that the power consumption of the pitch control system is reduced when the WTG is operating in the standby mode.

Abstract: A container (1) for consumer goods, the container comprises an outer sleeve (20) and inner tray (10) disposed within the outer sleeve (20), and configured to slide within the outer sleeve (20) between: a first position, in which the interior of the inner tray (10) cannot be accessed by a user; and a second position, in which the interior of the inner tray (10) can be accessed by a user. The container (1) has a locking mechanism for preventing the inner tray (10) from sliding with respect to the outer sleeve from the first position to the second position, when the inner tray (10) is in the first position in the outer sleeve (20).

Abstract: A device includes a display panel and a processor. The processor is to receive information corresponding to an image displayed on the display panel and determine whether a relevant portion of the image is centered with respect to an area of interest of the display panel. The processor is further to responsive to a determination that the relevant portion of the image is not centered with respect to the area of interest of the display panel, perform an operation to cause the relevant portion of the image to be adjusted such that the relevant portion of the image is centered with respect to the area of interest of the display panel.

Abstract: A method for separating biomass from solid fermentation product is provided. According to the method, a slurry comprising biomass and solid fermentation product is provided to the top of a biomass separator unit and an aqueous medium is provided to the bottom of a biomass separator unit, while a product stream comprising solid fermentation product is withdrawn from the bottom of the biomass separator unit and a waste stream comprising biomass is withdrawn from the top of the biomass separator unit.

Abstract: Embodiments include methods, performed by a user equipment (UE), for receiving reference signals (RS) in a wireless network. Such methods include receiving, from a network node in the wireless network, a configuration for connected-state RS transmitted by the network node. In some embodiments, the connected-state RS can be periodic channel state information RS (CSI-RS) or periodic tracking RS (TRS). Such methods include, while the UE is in a non-connected state and based on the received configuration, determining that the connected-state RS are available during one or more first occasions. Such methods include, while the UE is in the non-connected state, selectively receiving the connected-state RS during the first occasions. Other embodiments include complementary methods performed by a network node, as well as UEs and network nodes configured to perform such methods.

Abstract: Disclosed is an optoelectronic component comprising: an optoelectronic semiconductor chip which generates electromagnetic radiation during operation, and a metallic layer provided on the semiconductor chip, wherein an outer surface of the metallic layer has a patterning, the component can be identified by means of the patterning, and the metallic layer is continuous. Also disclosed is a method for producing an optoelectronic component.