Abstract: Known processes for preparing a porous carbon material with a hierarchical porosity comprise the steps of a) providing at least one carbon source and at least one amphiphilic species, b) combining the carbon source and the amphiphilic species to obtain a precursor material, and c) heating the precursor material to obtain the porous carbon material having a modal pore size and a pore volume. In order to avoid a lengthy hydrothermal treatment and to allow tunability of the pore size, pore size distribution and pore volume in carbon material, it is proposed that the heating step c) comprises a low temperature treatment in which the precursor material is heated to a first temperature in the range between 300° C. and 600° C. to obtain a self-assembled porous carbonaceous material, and wherein heating to the first temperature comprises a first average heating rate in the range of 0.5° C./min to 5° C./min.

Abstract: The present invention relates to 5?-cap compounds, in particular the stabilization of RNA by such 5?-cap compounds, and provides compositions, such as pharmaceutical compositions, and cells comprising an RNA which is modified with such a 5?-cap compound, as well as methods for producing a peptide or protein of interest using the compositions or cells according to the present invention. Furthermore, the present invention provides the RNA, compositions, or cells for use in therapy, in particular for use in a method of treating a disease or disorder by protein replacement therapy, genome engineering, genetic reprogramming, and immunotherapy; a method for increasing the stability of RNA in cells; a method for increasing the expression of RNA in cells; and a method for providing an RNA with a 5?-cap structure.

Abstract: The present invention relates to 5?-cap compounds, in particular the stabilization of RNA by such 5?-cap compounds, and provides compositions, such as pharmaceutical compositions, and cells comprising an RNA which is modified with such a 5?-cap compound, as well as methods for producing a peptide or protein of interest using the compositions or cells according to the present invention. Furthermore, the present invention provides the RNA, compositions, or cells for use in therapy, in particular for use in a method of treating a disease or disorder by protein replacement therapy, genome engineering, genetic reprogramming, and immunotherapy; a method for increasing the stability of RNA in cells; a method for increasing the expression of RNA in cells; and a method for providing an RNA with a 5?-cap structure.

Abstract: A process for preparing a porous carbon material. The process comprises the process steps: providing a carbon source; providing an amphiphilic species; contacting the carbon source and the amphiphilic species to obtain a precursor; and heating the precursor to obtain the porous carbon material; wherein the carbon source comprises a carbon source compound, wherein the carbon source compound comprises an aromatic ring having one or more attached OH groups and an ester link.

Abstract: The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in E.-coli, methods of propagating such nucleic acid molecules in E. coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

Abstract: The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.

Abstract: A process for preparation of a porous carbon material using an improved amphiphilic species. Also disclosed are a porous carbon material, devices comprising the porous carbon material and use of an amphiphilic compound for the preparation of a porous carbon material. The process for preparing a porous carbon material comprises the process steps: (a) providing a carbon source comprising a first carbon source compound; (b) providing an amphiphilic species comprising a first amphiphilic compound, the first amphiphilic compound comprising two or more adjacent ethylene oxide-based repeating units; (c) contacting the carbon source and the amphiphilic species to obtain a precursor; and (d) heating the precursor to obtain the porous carbon material.

Abstract: The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in E. coli, methods of propagating such nucleic acid molecules in E. coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

Abstract: The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3?-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.

Abstract: The thermal monitoring of a converter for an electric motor of a vehicle should be improved. Therefore, the invention relates to a method in which the temperature of the converter is measured. In addition, the output power of the converter is determined. The temperature of the converter is estimated using a thermal model of the converter having the output power as an input variable. The estimated temperature is compared with the measured temperature, and a corresponding monitoring signal is provided. Thus, a deviation of the measured temperature for the calculated temperature and thus a corresponding error in the cooling system can be detected even in the partial-load range.

Abstract: Disclosed herein is a method and an arrangement for the control of measuring systems such as a mass spectrometer or nuclear magnetic resonance (NMR) instrument, the control being based on an online data analysis of the current measurements. Depending on the measurement experiment, the combined result of the data analysis can have either a direct influence on the next measurement or result in a dynamically organized sequence of measurements. The measuring systems may be controlled by establishing a database that comprises information on the objects to be measured, the measurement data which can be detected during the measurement experiments using the measuring systems, and information regarding the relationships between or among items of the measurement data.

Abstract: The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in E. coli, methods of propagating such nucleic acid molecules in E. coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

Abstract: A drive system includes a line assembly configured to connect a power converter to an electric motor which has a brake and an encoder. The line assembly has at least two power lines and only two brake lines exclusively to provide a data transfer between the power converter and the electric motor and to transfer energy to the encoder. The power converter applies a first supply voltage of a first polarity and a second supply voltage of a second polarity opposite to the first polarity to the brake lines for supplying the brake and the encoder. The electric motor supplies the encoder with the respective supply voltage independently of its polarity and the brake with the respective supply voltage depending on its polarity.

Abstract: The present invention relates to modification of RNA with 5?-cap analogs of Formula (1): wherein R1-R6 and n are as described herein, in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antigen presenting cells comprising said stabilized RNA, and methods for stimulating and/or activating immune effector cells and for inducing an immune response in an individual using said stabilized RNA.

Abstract: A drive system includes a line assembly configured to connect a power converter to an electric motor which has a brake and an encoder. The line assembly has at least two power lines and only two brake lines exclusively to provide a data transfer between the power converter and the electric motor and to transfer energy to the encoder. The power converter applies a first supply voltage of a first polarity and a second supply voltage of a second polarity opposite to the first polarity to the brake lines for supplying the brake and the encoder. The electric motor supplies the encoder with the respective supply voltage independently of its polarity and the brake with the respective supply voltage depending on its polarity.

Abstract: In a method for thermal monitoring of a converter the temperature of the converter is measured. In addition, the output power of the converter is determined. The temperature of the converter is estimated by means of a thermal model of the converter having the output power as an input variable. The estimated temperature is compared with the measured temperature, and a corresponding monitoring signal is provided.

Abstract: There is described a display system which is used, in particular, in an industrial automation device. This display system has a first display panel which can be electrically operated and is transparent at least in parts and/or at times. The display system also has a second display panel, wherein the first display panel is positioned with respect to the second display panel in such a manner that the second display panel can be viewed through the first display panel. The second display panel is, in particular, a nameplate.

Abstract: The present invention relates to modification of RNA with 5?-cap analogs in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antigen presenting cells comprising said stabilized RNA, and methods for stimulating and/or activating immune effector cells and for inducing an immune response in an individual using said stabilized RNA.

Abstract: Disclosed herein is a method and an arrangement for the control of measuring systems such as a mass spectrometer or nuclear magnetic resonance (NMR) instrument, the control being based on an online data analysis of the current measurements. Depending on the measurement experiment, the combined result of the data analysis can have either a direct influence on the next measurement or result in a dynamically organized sequence of measurements. The measuring systems may be controlled by establishing a database that comprises information on the objects to be measured, the measurement data which can be detected during the measurement experiments using the measuring systems, and information regarding the relationships between or among items of the measurement data.

Abstract: A motor vehicle includes at least one first crash sensor for measuring a motion variable of the motor vehicle, arranged in a safety zone of the motor vehicle, and at least one second crash sensor for measuring a motion variable, arranged in a crash zone of the motor vehicle, the motor vehicle including an ignition protection device controllable via an ignition signal and a control unit for ascertaining the ignition signal as a function of the measured motion variables or, in each instance, as a function of a time average of the measured motion variables over at least one first time interval.